A5101466588- Cholesterol and Lipid Metabolism
- SARS-CoV-2 and COVID-19 Research
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Thyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Drug Transport and Resistance Mechanisms
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Renal Diseases and Glomerulopathies
- Alcoholism and Thiamine Deficiency
- Growth Hormone and Insulin-like Growth Factors
- Peroxisome Proliferator-Activated Receptors
- Pancreatitis Pathology and Treatment
- Cardiovascular Disease and Adiposity
- Gout, Hyperuricemia, Uric Acid
- Celiac Disease Research and Management
- COVID-19 Impact on Reproduction
- Adipose Tissue and Metabolism
- Pituitary Gland Disorders and Treatments
- Ion channel regulation and function
- Pancreatic function and diabetes
- Diabetes and associated disorders
Tufts University
1989-2019
Oregon Medical Research Center
2018
Framingham State University
2016-2018
Jean Mayer Human Nutrition Research Center on Aging
2017
United States Department of Veterans Affairs
1989
Boston Medical Center
1982
Boston University
1982
Low serum thyrotropin concentrations are a sensitive indicator of hyperthyroidism but can also occur in persons who have no clinical manifestations the disorder. We studied whether low clinically euthyroid older risk factor for subsequent atrial fibrillation.
We assessed secondary and genetic causes of severe HDL deficiency in 258,252 subjects, whom 370 men (0.33%) 144 women (0.099%) had cholesterol levels <20 mg/dl. excluded 206 subjects (40.1%) with significant elevations triglycerides, C-reactive protein, glycosylated hemoglobin, myeloperoxidase, or liver enzymes receiving testosterone. sequenced 23 lipid-related genes 201 (65.3%) 308 eligible subjects. Mutations (23 novel) selected variants were found at the following gene loci: 1) ABCA1...
We studied basal serum prolactin in older (> age 50) men (N = 501) and women 384) using younger adults for comparison excluding those taking medications. Serum rose slightly with increasing men; it fell until 80, when slightly. Men were not different except the higher value at 20 to 29. did fall after menopause, while estrogen treatment had no effect on caused only a slight rise men. Thyroid deficiency minimal raise above 25 ng/ml. The prevalence of clearly elevated values nglml) was 1.3%...
Most deaths from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection occur in older subjects. We assessed the utility of serum inflammatory markers interleukin-6 (IL-6), C reactive protein (CRP), and ferritin (Roche, Indianapolis, IN), SARS-CoV-2 immunoglobulin G (IgG), M (IgM), neutralizing antibodies (Diazyme, Poway, CA). In controls, non-hospitalized subjects, hospitalized subjects for RNA (n = 278), median IgG levels arbitrary units (AU)/mL were 0.05 negative 14.83...
ABSTRACT Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has been associated with a worldwide pandemic. We assessed data as of November 25, 2020 from our combined laboratories and reported for states in the United States (US) countries case, death, testing rates per million to determine causes rate differences. SARS-CoV-2 naso-pharyngeal (NP) RNA 1,179,912 subjects 47 (39 which >100 cases) are reported, mean 9.3% positive rate, comparable 7.0% nationwide. In 91...
Abstract Most deaths from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection occur in older subjects. We assessed age effects and clinical utility of serum SARS-CoV-2 immunoglobulin G (IgG), M (IgM), neutralizing antibodies inflammatory markers. Serum IgG, IgM, antibody levels were measured using chemiluminescence assays Diazyme (Poway, CA), while interleukin-6 (IL-6), C reactive protein (CRP), ferritin with immunoassays obtained Roche (Indianapolis, IN). In 79,005...
Aim: Our goal was to assess the population prevalence, genetics and clinical phenotypes of subjects with marked HDL deficiency. Methods: 200 (26% female, mean age 52 years) serum HDL-C < 20 mg/dL, fasting triglycerides (TG) 600 C reactive protein (CRP) 10 mg/L, myeloperoxidase (MPO) 1000 pmoles/L, HbA1c 8.0%, liver transaminases 120 U/L, not taking anabolic steroids were studied. Lipids, inflammation markers, enzymes, particles assessed; sequencing 31 lipid metabolism genes including...
Objective: About 80% of corona virus disease-19 (COVID-19) deaths due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection occur in subject’s ≥ 65 years age, even though subjects this age group only account for about 10% COVID-19 cases. Our objectives were assess effects and the clinical utility of antibody levels health, disease, post-vaccination. Methods: We measured serum SARS-CoV-2 immunoglobulin M (IgM), IgG neutralizing antibodies using immunoassay kits...