A5009755596- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Obsessive-Compulsive Spectrum Disorders
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Transcranial Magnetic Stimulation Studies
- Neurotransmitter Receptor Influence on Behavior
- Face Recognition and Perception
- Psychosomatic Disorders and Their Treatments
- Heart Rate Variability and Autonomic Control
- Pain Management and Placebo Effect
- Personality Disorders and Psychopathology
- Traumatic Brain Injury Research
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Pain Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Sexual function and dysfunction studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Contact Dermatitis and Allergies
- Posttraumatic Stress Disorder Research
- Dermatology and Skin Diseases
- Semiconductor Lasers and Optical Devices
- Acupuncture Treatment Research Studies
- Advanced MRI Techniques and Applications
University of California, San Francisco
2017-2024
CollegeAmerica
2023
University of Wisconsin–Madison
2011-2016
University of New Mexico
2012-2013
Mind Research Network
2012-2013
Linking psychopathy to a specific brain abnormality could have significant clinical, legal, and scientific implications. Theories on the neurobiological basis of disorder typically propose dysfunction in circuit involving ventromedial prefrontal cortex (vmPFC). However, date there is limited imaging data directly test whether may indeed be associated with any structural or functional within this area. In study, we employ two complementary techniques assess connectivity vmPFC psychopathic...
Objective: Psychopathy is a personality disorder associated with severely antisocial behavior and host of cognitive affective deficits. The neuropathological basis the has not been clearly established. Cortical thickness sensitive measure brain structure that used to identify neurobiological abnormalities in number psychiatric disorders. authors assessed cortical corresponding functional connectivity psychopathic prison inmates. Method: Using T1 MRI data, computed maps sample adult male...
Abstract Substance use disorders (SUD) have been associated with dysfunction in reward processing, habit formation, and cognitive‐behavioral control. Accordingly, neurocircuitry models of addiction highlight roles for nucleus accumbens, dorsal striatum, prefrontal/anterior cingulate cortex. However, the precise nature disrupted interactions between these brain regions SUD, psychological correlates thereof, remain unclear. Here we used magnetic resonance imaging to measure rest‐state...
Psychopathy is a personality disorder characterized by callous antisocial behavior and criminal recidivism. Here we examine whether psychopathy associated with alterations in functional connectivity three large-scale cortical networks. Using fMRI 142 adult male prison inmates, computed resting-state using seeds from the default mode network, frontoparietal cingulo-opercular network. To determine specificity of our findings to these networks, also calculated two comparison primary sensory...
Abstract Psychopathy is a personality disorder characterized by callous lack of empathy, impulsive antisocial behavior, and criminal recidivism. Here, we performed the largest diffusion tensor imaging (DTI) study incarcerated offenders to date ( N = 147) determine whether psychopathy severity linked microstructural integrity major white matter tracts in brain. Consistent with results previous studies smaller samples, found that was associated reduced fractional anisotropy right uncinate...
The ventral striatum and ventromedial prefrontal cortex (vmPFC) are two central nodes of the “reward circuit” brain. Human neuroimaging studies have demonstrated coincident activation functional connectivity between these brain regions, animal that vmPFC modulates activity. However, there been no comparable data in humans to address whether may be critical for reward-related response properties striatum. In this study, we used fMRI five neurosurgical patients with focal lesions test...
The ventromedial prefrontal cortex is known to play a crucial role in regulating human social and emotional behaviour, yet the precise mechanisms by which it subserves this broad function remain unclear. Whereas previous neuropsychological studies have largely focused on of higher-order deliberative processes related valuation decision-making, here we test whether may also be critical for more basic aspects orienting attention socially emotionally meaningful stimuli. Using eye tracking...
Psychopathy is a personality disorder associated with callous and impulsive behavior criminal recidivism. It has long been theorized that psychopaths have deficits in processing reward punishment. Here, we use structural functional magnetic resonance imaging to examine the neural correlates of loss sensitivity group psychopaths. Forty-one adult male prison inmates (n = 18 n 23 non-psychopaths) completed task involving gain or money. Across entire sample participants, monetary gains elicited...
Precision neuromodulation of central brain circuits is a promising emerging therapeutic modality for variety neuropsychiatric disorders. Reliably identifying in whom, where, and what context to provide stimulation optimal pain relief are fundamental challenges limiting the widespread implementation treatments chronic pain. Current approaches target empirically derived regions interest disorder or targets with strong connections these regions. However, complex, multidimensional experiences...
Uncertainty is a ubiquitous feature of our daily lives. Although previous studies have identified number neural and peripheral physiological changes associated with uncertainty, there are limited data on the causal mechanisms underlying these responses in humans. In this study, we address empirical gap through novel application fMRI neurosurgical patients focal, bilateral ventromedial prefrontal cortex (vmPFC) damage. The task involved cued anticipation aversive neutral picture stimuli;...
Pain is strongly modulated by expectations and beliefs. Across species, subregions of ventromedial prefrontal cortex (VMPFC) are implicated in a variety functions germane to pain, predictions, learning. Human fMRI studies show that VMPFC activity tracks about pain mediates expectancy effects on pain-related other brain regions. Prior lesion suggest may instead play more general role generating affective responses painful stimuli. To test whether required generate or specifically involved...
Background: Deep brain stimulation (DBS) of the anterior limb internal capsule (ALIC) is an emerging treatment for severe, refractory obsessive-compulsive disorder (OCD). The therapeutic effects DBS are hypothesized to be mediated by direct modulation a distributed cortico-striato-thalmo-cortical network underlying OCD symptoms. However, exact mechanism which exerts its still remains unclear. Method: In five participants receiving (3 responders, 2 non-responders), we conducted On/Off cycling...
Here, we obtained pre-operative fMRI and intracranial recordings from two subjects with treatment-refractory depression undergoing stereoencephalography as part of a DBS study. Intracranial were leads bilaterally implanted in the orbitofrontal cortex, subgenual cingulate, ventral striatum, hippocampus, amygdala. fMRI-based resting-state functional connectivity (RSFC) was calculated for ROIs defined by recording sites. We identified significant spatial correlations between power bandpassed...
Deep brain stimulation (DBS) of the anterior limb internal capsule (ALIC) is a circuit-based treatment for severe, refractory obsessive-compulsive disorder (OCD). The therapeutic effects DBS are hypothesized to be mediated by direct modulation distributed cortico-striato-thalmo-cortical network underlying OCD symptoms. However, exact mechanism which exerts its still remains unclear. In five participants receiving (3 responders, 2 non-responders), we conducted On/Off cycling paradigm during...