A5039094707- Cardiac Valve Diseases and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Elasticity and Material Modeling
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Graphene and Nanomaterials Applications
- Electrochemical sensors and biosensors
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Bone Tissue Engineering Materials
- Nanoparticles: synthesis and applications
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Microfluidic and Capillary Electrophoresis Applications
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Collagen: Extraction and Characterization
- Cardiac, Anesthesia and Surgical Outcomes
- Mesenchymal stem cell research
- Smart Cities and Technologies
- Luminescence Properties of Advanced Materials
- Vehicle License Plate Recognition
- Connective tissue disorders research
- Space Satellite Systems and Control
National Institute of Technology Rourkela
2019-2025
University of Oklahoma
2018-2023
AAA College of Engineering and Technology
2022-2023
Graz University of Technology
2019-2022
Indian Institute of Science Bangalore
2013-2015
Abstract Collagen plays a key role in the strength of aortic walls, so studying micro-structural changes during disease development is critical to better understand collagen reorganization. Second-harmonic generation microscopy used obtain images human both healthy and diseased states. Methods are being developed order efficiently determine waviness, that is, tortuosity amplitude, as well diameter, orientation, dispersion fibers, bundles aneurysmal tissues. The results show layer-specific...
Eggshell (ES) wastes have been ranked as the 15th food industry pollution due to ever-increasing regular consumption of primary dietary products, eggs. Management and treatment tons discarded eggshells produced daily on a global scale are realized be predicament, an immediate solution must advocated address pollution. This sets tone for recyclability this biowaste in myriad fields, like nanotechnology, biomedical, environmental control. Calcium carbonate shells makes it safe precursor...
Thoracic aortic dissections are associated with a significant risk of morbidity and mortality, currently challenge our understanding the biomechanical factors leading to their initiation propagation. We quantified biaxial mechanical properties human type A (n = 16) modeled stress-strain data using microstructurally motivated form strain energy function. Our results show significantly higher stiffness for dissected tissues as compared control aorta without arterial disease. Higher did not,...
We use enzymatic manipulation methods to investigate the individual and combined roles of elastin collagen on arterial mechanics. Porcine aortic tissues were treated for differing amounts time using enzymes elastase collagenase cause degradation in substrate proteins obtain variable tissue architecture. equibiaxial mechanical tests quantify material properties control enzyme histological visualize underlying microstructure tissues. Our results show that more compliant longitudinal direction...
The atrioventricular heart valve (AHV) leaflets have a complex microstructure composed of four distinct layers: atrialis, ventricularis, fibrosa and spongiosa. Specifically, the spongiosa layer is primarily proteoglycans glycosaminoglycans (GAGs). Quantification GAGs' mechanical contribution to overall leaflet function has been recent focus for aortic leaflets, but this characterization not reported AHV leaflets. This study seeks expand current GAG literature through novel characterizations...
This dataset contains the anisotropic tissue responses of porcine atrioventricular valve leaflets to force-controlled biaxial mechanical testing. The set includes first Piola-Kirchhoff Stress and specimen stretches (λ) in both circumferential radial directions (C R, respectively) for mitral anterior posterior (MVAL MVPL), tricuspid anterior, posterior, septal (TVAL, TVPL, TVSL) from six hearts at five separate loading protocols. is associated with a companion journal article, which can be...
Background: The development of polymeric-based drug delivery has seen faster growth in the past two decades. In polymers, copolymers as carriers are increasing to decrease compounds' side effects and dosage-related toxicity. Objectives: study's primary objective is utilize computational resources design molecules perform silco physicochemical property analysis. our study, we designed new based on N-(2-Hydroxypropyl) methacrylamide (HPMA) backbone along with polyethylene glycol (PEG) lauryl...
Abstract Secreted protein acidic and rich in cysteine (SPARC), is a multifunction that interacts with extracellular matrix (ECM), cell surface receptors, signaling molecules. These interactions cancer cells result less susceptible of to the immune system, leading poor prognosis. SPARC plays crucial role transporting collagen, significant component ECM, from site synthesis basement membrane cells. Collagen mediated rigidity enhancement microenvironment promotes growth, proliferation,...
Abstract Biodegradable drug‐eluting stents (DESs) are gaining importance owing to their attractive features, such as complete drug release the target site. Magnesium (Mg) alloys promising materials for future biodegradable DESs. However, there few explorations using Mg cardiovascular stent application. In this present study, sirolimus‐loaded poly D, L‐lactic‐co‐glycolic acid (PLGA)‐coated/ sirolimus‐fixed/AZ91 alloy‐based substrate was developed via a layer‐by‐layer approach The AZ91 alloy...