A5047539855- Analytical Chemistry and Chromatography
- Spectroscopy and Chemometric Analyses
- Analytical Methods in Pharmaceuticals
- Computational Drug Discovery Methods
- Chromatography in Natural Products
- Phytochemicals and Antioxidant Activities
- Metabolomics and Mass Spectrometry Studies
- Crystallization and Solubility Studies
- Antibiotics Pharmacokinetics and Efficacy
- Protein purification and stability
- Pesticide Residue Analysis and Safety
- Essential Oils and Antimicrobial Activity
- Microfluidic and Capillary Electrophoresis Applications
- Heavy Metals in Plants
- Phytochemistry and Biological Activities
- Advanced Chemical Sensor Technologies
- Analytical chemistry methods development
- Natural product bioactivities and synthesis
- Botany and Plant Ecology Studies
- Fault Detection and Control Systems
- X-ray Diffraction in Crystallography
- Angiogenesis and VEGF in Cancer
- Advanced Statistical Methods and Models
- Image and Signal Denoising Methods
- Coronary Interventions and Diagnostics
Medical University of Lublin
2015-2024
Medicina
2002-2024
Green tea infusions are one of the most popular beverages consumed across world, especially is Asian countries. quality primarily based on catechin content, however, concentration elements could also significantly influence its biological properties and thus safety. The main purpose present study was evaluation catechin, antioxidant activity metal content (K, Na, Ca, Mg, Fe, Mn, Cu, Zn, Cr, Pb, Cd Ni) in different green types cultivated Japan, Sri Lanka, South Korea, India, China Japan....
Isoquinoline alkaloids belong to the toxic secondary metabolites occurring in plants of many families. The high biological activity makes these compounds promising agents for use medicine, particularly as anticancer drugs. aim our study was evaluate cytotoxicity and proapoptotic sanguinarine, berberine, extracts Chelidonium majus L. Berberis thunbergii DC. IC10, IC50, IC90 doses were established toward hematopoietic cancer cell lines using trypan blue staining. Alterations expression 18...
The cytotoxic and antioxidant properties of lipophilic compounds extracted from different parts four Chenopodium L. (Chenopodium album, hybridum, rubrum urbicum) species were evaluated. highest phenolic content was found in herb seeds all examined plants. Large amounts free polyphenols observed extracts C. album (3.36 mg/g DW), urbicum (3.87 DW) roots (1.52 DW). activities the assessed against human lung carcinoma A-549 ovarian TOV-112D normal fibroblast cell lines. Our study demonstrated...
In vitro callus cultures of Verbena officinalis L. were maintained on solid Murashige and Skoog medium, enriched with 1 mg dm−3 BA IBA under LED lights (red, blue, red/blue 70%/30%), in darkness control fluorescent lamps. The measurements 2 phenylpropanoid glycosides (verbascoside isoverbascoside) 23 phenolic acids performed methanolic extracts from the biomass collected after 2-, 3- 4-week growth cycles using HPLC-DAD method. presence verbascoside, isoverbascoside additionaly 7...
The article is intended to introduce and discuss a new quantile regression method for baseline detrending of chromatographic signals. It compared with current methods based on polynomial fitting, spline LOESS, Whittaker smoother, each thresholding reweighting approach. For curve flexibility selection in existing algorithms, skewness the residuals successfully applied. computational efficiency all approaches also discussed. newly introduced could be preferred visible better performance short...
A comprehensive study on the composition and antioxidant properties of black tea samples with a chemometric approach was performed via LC-ESI-Q-TOF-MS, DPPH radical scavenging assay, Folin-Ciocalteu assay (TPC). Marked differences between teas from seven different countries (China, India, Iran, Japan, Kenya, Nepal, Sri Lanka) were shown. The Indian demonstrated highest total catechin content (184.8 mg/100 mL), largest TPC potential (58.2 mL 84.5%, respectively). applied principal component...
Atherosclerosis and it's comorbidities are the major contributors to global burden of death worldwide. Lower extremities arterial disease (LEAD) is a common manifestation atherosclerotic arteries lower extremities. MicroRNAs belong epigenetic factors that regulate gene expression have not yet been extensively studied in LEAD. We aimed indicate most promising microRNA signatures disease, identify interactions between genes describe potential effect modulated expression. High-throughput...
The aim of this study was to evaluate the ability multivariate techniques predict antioxidant and cytotoxic activity selected lichens from chromatographic data. A simple reproducible HPLC-DAD technique has been used obtain fingerprint profiles. Reversed phase high performance liquid chromatography (RP-HPLC) linear gradient system with methanol, water phosphoric acid (V) (pH 2.3) as mobile (50 min). Principal Component Analysis (PCA) applied evaluation phytochemical similarity between studied...
The aim of this study was to determine if altered levels selected trace elements manifest themselves during chronic depression. To identify strongly associated with depression, relationships between the elemental contents hair and nails interelement correlations were checked. Inductively coupled plasma mass spectrometry ion chromatography used evaluate Zn, Cu, Co, Pb, Mn, Fe in nail samples from a total 415 subjects (295 patients 120 healthy volunteers). included logistic regression models...
The paper is written as an introductory review, presenting summary of current knowledge about chemometric fingerprinting in the context TLC, due to a rather small interest literature joining TLC and chemometrics. shortly covers most important aspects general, creating fingerprints, denoising, baseline removal, warping/registering, processing itself. References being good candidates starting point are given for each topic step.
The lipophilicity (R(M0)) and specific hydrophobic surface area for the representatives of four generation cephalosporins have been determined by reversed-phase thin-layer chromatography, effect different mobile-phase modifiers (such as methanol, acetonitrile, acetone, 1,4-dioxane 2-propanol) on retention has studied. compounds studied showed typical behavior; their R(M) values decreased linearly with increasing concentration organic modifier in eluent. linear correlations between volume...
The present paper describes the chemical composition of essential oils obtained by hydrodistillation from four Impatiens species, glandulifera Royle, I. parviflora DC., balsamina L. and noli-tangere GC GC-MS methods resulted in identification 226 volatile compounds comprising 61.7%-88.2% total amount. differed significantly their composition. Fifteen were shared among all investigated species. majority these constituents was linalool (0.7%-15.1%), hexanal (0.2%-5.3%) benzaldehyde...
Chronic venous disease (CVD) is a vascular of lower limbs with high prevalence worldwide. Pathologic features include varicose veins, valves dysfunction and skin ulceration resulting from cell proliferation, apoptosis angiogenesis. These processes are partly regulated by microRNA (miRNA)-dependent modulation gene expression, pointing to miRNA as potentially important target in diagnosis therapy CVD progression. The aim the study was analyze alterations expression CVD, well identify...
Hemerocallis plants are important vegetables with nutritional and health value, especially in eastern Asia, where they have been used as medicines to cure disease such depression inflammation for thousands of years. The present study concerns the determination flavonoids phenolic acids, well antioxidant, anti-collagenase, anti-elastase, anti-tyrosinase antimicrobial properties taxa cultivated Poland. For chemical composition estimation, LC-ESI-MS/MS analysis spectrophotometric assays were...