A5037225061- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Inflammatory mediators and NSAID effects
- Computational Drug Discovery Methods
- Pharmaceutical and Antibiotic Environmental Impacts
- Phenothiazines and Benzothiazines Synthesis and Activities
- Analytical Chemistry and Sensors
- Synthesis and Characterization of Heterocyclic Compounds
- Pesticide Residue Analysis and Safety
- Synthesis and Biological Evaluation
- Metabolomics and Mass Spectrometry Studies
- Drug Transport and Resistance Mechanisms
- Analytical chemistry methods development
- Free Radicals and Antioxidants
- Advanced Chemical Sensor Technologies
- Chemical Synthesis and Analysis
- Synthesis of β-Lactam Compounds
- Antibiotic Resistance in Bacteria
- Phosphodiesterase function and regulation
- Diet and metabolism studies
- Fungal Biology and Applications
- Pharmacological Effects and Assays
- Vitamin D Research Studies
- Chromatography in Natural Products
Jagiellonian University
2016-2025
Czech Academy of Sciences, Institute of Analytical Chemistry
2010
Alzheimer's disease (AD) has a complex and not-fully-understood etiology. Recently, the serotonin receptor 5-HT6 emerged as promising target for AD treatment; thus, here new series of 5-HT6R ligands with 1,3,5-triazine core selenoether linkers was explored. Among them, 2-naphthyl derivatives exhibited strong affinity selectivity over 5-HT1AR (13–15), 5-HT7R (14 15), 5-HT2AR (13). Compound 15 displayed high other central nervous system receptors low risk cardio-, hepato-, nephrotoxicity no...
Among serotonin receptors, the 5-HT6 subtype is an important protein target and its ligands may play a key role in innovative treatment of cognitive disorders. This study aimed to extend body preclinical research on two naphthyl-derived methylpiperazine-1,3,5-triazine analogues with thioether (WA-22) or Se-ether (PPK-32) linkers, newly described compounds having high affinity selectivity for receptors drug-like parameters vitro. Thus, crystallography-supported deeper insight into their...
Micro- and nanoplastic pollutants are among the major environmental challenges, exacerbated by continuous degradation of growing amounts plastic debris in aquatic environment. The purpose this study was to investigate morphology micro/nanoplastics (M/NPs) formed from polyethylene terephthalate (PET) mechanical an environment, which mimics processes natural environment well, determine impact these particles on model organisms. To end, M/NPs were obtained ball milling aqueous medium effect...
The formation of cefuroxime axetil+cyclodextrin (CA+CD) complexes increases the aqueous solubility CA, improves its physico-chemical properties, and facilitates a biomembrane-mediated drug delivery process. In CD-based tablet formulations, it is crucial to investigate molecular details in final pharmaceutical preparation. this study, Raman spectroscopy mapping were applied for detection identification chemical groups involved α-, β-, γ-, 2-hydroxypropyl-β-CD (2-HP- β-CD)+CA complexation...
In recent years, ultra-efficient liquid chromatography (UPLC) has gained particular popularity due to the possibility of faster separation small molecules. This technique, used separate ingredients present in multi-component mixtures, found application many fields, such as chemistry, pharmacy, food, and biochemistry. It is an important tool both research production. UPLC created new possibilities for analytical without reducing quality obtained results. technique therefore a milestone...
This study focuses on the design, synthesis, biological evaluation, and computer-aided structure-activity relationship (SAR) analysis for a novel group of aromatic triazine-methylpiperazines, with an hydantoin spacer between 1,3,5-traizine fragment. New compounds were synthesized their affinities serotonin 5-HT₆, 5-HT1A, 5-HT2A, 5-HT₇, dopamine D₂ receptors evaluated. The induced-fit docking (IFD) procedure was performed to explore 5-HT₆ receptor conformation space employing two lead...
Lipophilicity study of selected NSAIDs, the group bioactive compounds usually used in humans and animals medicine, with use experimental calculation methods was evaluated. LogP values are proposed compared as descriptors lipophilicity eleven (from oxicams coxibs). Obtained data were designated by thin-layer chromatography (TLC) various chromatographic conditions, stationary phases different properties. The mobile phase systems prepared mixing respective amounts water organic modifier,...
Abstract Research studies have been carried out to develop a chromatographic and densitometric method suitable for identification determination of tramadol impurities. In addition, the stability in solutions was investigated, including an effect solution pH, temperature incubation time. first instance conditions quantitative impurities pharmaceutical preparations were established. The separation performed on silica gel‐coated plates (HPTLC) using two mobile phases: (I)...
Vitamins are a unit of organic chemical substances that essential for the adequate working human body. Water-soluble B vitamins involved in regulation many metabolic and regulatory processes. Due to inability synthesize endogenously, they must be supplied body with edibles or form supplementation as drugs dietary supplements. Maintaining correct level is extremely important treatment various diseases. In presented work, qualitative quantitative procedure assay B1, B2, B5, B6 B12...
Pollution of the environment with inorganic and organic substances is one main problems in world. For this reason, it necessary to conduct researches for effective methods biodegradation xenobiotics, including drugs whose unmetabolized forms are introduced into environment, especially water. One possible solution problem may be use white rot fungi, such as Lentinula edodes. This an edible species used medicine because its beneficial anti-cancer, hypocholesterolemic, hypotensive, hypoglycemic...
β-carotene as a dietary supplement is matter of interest to anyone who seeks improve their skin condition or sight. Due its antioxidative properties, carotenoids are involved in the prevention severe conditions, such cancer, heart disease, macular degeneration, cataract, which makes them an object scientific study. Thanks color, ß-carotene used food colorant, improving appearance foodstuff. A presented method was established for identification and quantification by thin-layer chromatography...
A rapid, accurate and sensitive thin-layer chromatography (TLC) method with densitometric detection has been developed validated for the determination of cefepime in pharmaceuticals. Chromatographic separation was achieved on a silica gel TLC F254 plates mobile phase consisting ethanol-2-propanol-glacial acetic acid 99.5%-water (4:4:1:3, v/v). Densitometric carried out at wavelength 266 nm reflectance/absorbance mode. The validation found to be satisfactory high accuracy (from 99.24 101.37%)...
Metronidazole is a drug widely used in the prevention and treatment of bacterial infections. Due to its possibility formation stable metal complexes, it was decided broaden activity spectrum by introducing silver(I) coordination compounds i.e., [Ag(MTZ)2NO3] [(Ag(MTZ)2)2]SO4, which have significant antibacterial properties. The paper presents description new qualitative quantitative analysis metronidazole bulk possible pharmaceutical preparations thin-layer chromatography with densitometric...
Abstract Lecithin is a mixture of phospholipids which naturally occurs in plants and animals cells. This component drugs as well dietary supplements, are used to improve memory concentration, likewise decrease cholesterol level blood, risk cardiovascular diseases lot other cases. In this paper the quantitative qualitative analysis phosphatidylcholine, main lecithin, by thin-layer chromatography with densitometric detection, was described. First, method validated according International...