A5027453313- Cardiac electrophysiology and arrhythmias
- Connective tissue disorders research
- Cardiac Arrhythmias and Treatments
- Bone fractures and treatments
- Cardiac Imaging and Diagnostics
- Bone health and treatments
- Atrial Fibrillation Management and Outcomes
- Virus-based gene therapy research
- Osteoarthritis Treatment and Mechanisms
- Infective Endocarditis Diagnosis and Management
- Sarcoma Diagnosis and Treatment
- Alkaline Phosphatase Research Studies
- Muscle Physiology and Disorders
- Advanced MRI Techniques and Applications
- RNA regulation and disease
- Bone Metabolism and Diseases
- Microencapsulation and Drying Processes
- Protein Tyrosine Phosphatases
- Biomedical Ethics and Regulation
- Bone and Dental Protein Studies
- Cardiovascular Function and Risk Factors
- Probiotics and Fermented Foods
- TGF-β signaling in diseases
- Proteins in Food Systems
- Orthopaedic implants and arthroplasty
Children's Hospital at Westmead
2020-2025
The University of Sydney
2020-2025
Westmead Institute for Medical Research
2020-2025
Bioengineering (Switzerland)
2024
Sydney Children's Hospital
2022
Objective The prevalence of comorbid chronic kidney disease (CKD) and osteoarthritis (OA) is increasing globally. While sharing common risk factors, the mechanism consequences concurrent CKD-OA are unclear. aims study were to develop a preclinical model, investigate disease-modifying interactions. Methods Seventy (70) male 8–10 week-old C57BL/6 mice subjected 5/6 nephrectomy (5/6Nx)±destabilisation medial meniscus (DMM) or sham surgery. OA pathology CKD assessed 12 weeks postinduction by...
BACKGROUND: Cardiac magnetic resonance imaging (CMR)–defined ventricular scar and anatomic conduction channels (CMR-CCs) offer promise in delineating tachycardia substrate. No studies have validated with coregistered histology, nor they ascertained the histological characteristics of deceleration zones (DZs) within these channels. We aimed to validate CMR CMR-CCs whole-heart histology electroanatomic mapping a postinfarction model. METHODS: Five sheep underwent anteroseptal infarction....
Probiotics health benefits are hampered by long-term storage, gastrointestinal transit, and lack of adequate colonization within the colon. To this end, we have designed a core–shell structure that features an acid resistant core formulation with low water activity composed alginate, hydroxypropyl methyl cellulose, gellan gum (AHG) mucoadhesive shell made from chemically modified carboxymethyl chitosan polyethylenimine (PEI-CMC). The microparticles was examined using scanning electron...
Introduction: Osteomyelitis remains a major clinical challenge. Many published rodent fracture infection models are costly compared with murine for rapid screening and proof-of-concept studies. We aimed to develop dependable cost-effective bone model that mimics bacterial infections associated biofilm metal implants. Methods: Tibial drilled hole (TDH) needle insertion surgery (NIS) were in C57BL/6 mice (female, N=150 ). Metal pins inserted selectively into the medullary canal adjacent defect...
Osteogenesis imperfecta (OI) is a genetic bone fragility disorder that features frequent fractures. Bone healing outcomes are contingent on proper balance between formation and resorption, drugs such as morphogenetic proteins (BMPs) bisphosphonates (BPs) have shown to utility in modulating fracture repair. While BPs used for OI increase BMD reduce pain rates, there little evidence using BMPs local agents (alone or with BPs). In this study, we examined wild-type mice (Col1a2+/G610C ) murine...
Neurofibromatosis type 1 (NF1) is a complex genetic disorder that affects range of tissues including muscle and bone. Recent preclinical clinical studies have shown Nf1 deficiency in causes metabolic changes resulting intramyocellular lipid accumulation weakness. These can be subsequently rescued by dietary interventions aimed at modulating availability metabolism. It was speculated the modified diet may rescue defects cortical bone as NF1 has been reported to affect genes involved with Bone...
Significance: Current methods for analyzing pathological muscle tissue are time consuming and rarely quantitative, they involve invasive biopsies. Faster less diagnosis of disease may be achievable using marker-free in vivo optical sensing methods. Aim: It was speculated that changes the biochemical composition structure associated with pathology could measured quantitatively visible wavelength spectroscopy techniques enabling automated classification. Approach: A fiber-optic...
The creation of murine gene knockout models to study bone functions often requires the resource intensive crossbreeding Cre transgenic and gene-floxed strains. developmental versus postnatal roles genes can be difficult discern in such models. For example, embryonic deletion Sclerostin (Sost) establishes a high-bone mass phenotype neonatal mice that may impact on future growth. To generate skeletal Sost adult mice, this used single injection bone-targeted recombinant adeno-associated virus...