A5087374760- Bone health and treatments
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Bone health and osteoporosis research
- Connective tissue disorders research
- Hip disorders and treatments
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Neurofibromatosis and Schwannoma Cases
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- TGF-β signaling in diseases
- Bone Tissue Engineering Materials
- Scoliosis diagnosis and treatment
- Foot and Ankle Surgery
- Spine and Intervertebral Disc Pathology
- Soft tissue tumor case studies
- Heterotopic Ossification and Related Conditions
- Medical Imaging and Pathology Studies
- Tendon Structure and Treatment
- Radiopharmaceutical Chemistry and Applications
- Growth Hormone and Insulin-like Growth Factors
- Bone Tumor Diagnosis and Treatments
- Lower Extremity Biomechanics and Pathologies
- Pelvic and Acetabular Injuries
The University of Sydney
2015-2024
Children's Hospital at Westmead
2015-2024
Westmead Institute for Medical Research
2022-2024
Royal United Hospital
2022-2024
Royal United Hospital Bath NHS Trust
2022-2024
Sydney Children's Hospital
1993-2022
Novartis (Switzerland)
2003-2018
N8 Medical (United States)
2018
Professional Beef Services
2018
Bristol-Myers Squibb (Switzerland)
2018
Background: Our aim was to compare height velocity data, obtained from clinical measurements, for girls who had idiopathic scoliosis with the data adolescents did not have scoliosis. We also compared growth chronological age, menarchal and Risser sign in terms of their accuracy prediction progression Methods: One hundred twenty 371 patients a database managed brace treatment sufficient us quantify peak. Height generated standing-height measurements obtained, clinic, minimum six-month...
Abstract We hypothesized that ZA treatment would bolster fracture repair. In a rat model for closed healing, single dose of at 0, 1, or 2 wk after significantly increased BMC and strength the healed fracture. Delaying (1 fracture) displayed superior results compared with dosing time Introduction: Bisphosphonates are known to increase bone thus resistance by decreasing osteoclastic resorption. These properties may enable bisphosphonates also Zoledronic acid (ZA) is potent bisphosphonate high...
The importance of neuropeptide Y (NPY) and Y2 receptors in the regulation bone energy homeostasis has recently been demonstrated. However, contributions other are less clear. Here we show that Y1 expressed on osteoblastic cells. Moreover, adipose tissue mass elevated Y1(-/-) mice with a generalized increase formation cortical cancellous surfaces. Importantly, inhibitory effects NPY marrow stromal cells vitro absent derived from mice, indicating direct action via this receptor. Interestingly,...
We evaluated the gait of thirty-five neurologically normal children who had a limb-length discrepancy lower extremities that ranged from 0.8 to 15.8 per cent length long extremity (0.6 11.1 centimeters). The twenty-two boys and thirteen girls an average age years (range, eight seventeen years). No patient substantial angular or rotational deformity extremities. found no correlation between actual any dependent kinematic kinetic variables, including pelvic obliquity. Discrepancies less than 3...
Changes in whole body energy levels are closely linked to alterations weight and bone mass. Here, we show that hypothalamic signals contribute the regulation of mass a manner consistent with central perception status. Mice lacking neuropeptide Y (NPY), well-known orexigenic factor whose expression is increased fasting, have significantly association enhanced osteoblast activity elevated osteogenic transcription factors, Runx2 Osterix. In contrast, wild type NPY knockout (NPY −/−) mice which...
ABSTRACT Sclerostin, encoded by the Sost gene, is an important negative regulator of bone formation that has been proposed to have a key role in regulating response mechanical loading. To investigate effect long-term Sclerostin deficiency on mechanotransduction bone, we performed experiments unloaded or loaded tibiae 10 week old female Sost−/− and wild type mice. Unloading was induced via 0.5U botulinum toxin (BTX) injections into right quadriceps calf muscles, causing muscle paralysis limb...
Study Design A retrospeotive analysis of the change in Oswestry Low Back Pain Disability Questionaire a heterogeneous group 144 operatively managed patients was undertaken to examine disability index as an outcome measure. Objectives To establish percent measure able identity risk factors for poor results lumbar spinal surgery. Methods Epidemiologic, diagnostic, and surgical variables were examined using step-wise multiple linear regression at both follow-up times (6 months 2 years), with...
Osteonecrosis (ON) of the femoral head in childhood can lead to loss architecture and subsequent deformity. When ON was surgically induced 24 rats, zoledronic acid treatment prophylaxis improved sphericity maintenance at 6 weeks. This preliminary experiment supports use bisphosphonates ON.We hypothesized that bisphosphonate could preserve structure while allowing bone repair.Osteonecrosis right female Wistar rats. The rats were randomized into three groups dosed subcutaneously with saline,...
Bone repair involves both anabolic and catabolic responses. We hypothesized that treatment with OP-1 (BMP-7) anti-catabolic zoledronic acid could be synergistic. In a rat critical defect, this combination therapy produced significant increases in new bone volume strength.When used to augment healing, osteogenic protein 1 (OP-1/BMP-7) other BMPs stimulate the response, inducing osteoblast recruitment, differentiation, production. However, can also upregulate catabolism by direct stimulation...
Complications in fracture repair that lead to a delay union remain clinically problematic. We believe unwanted pre-mature catabolism of the healing callus, for example, stress shielded situations, diminishes rate at which strength is restored bone and possibly leads delayed union. hypothesized single systemic dose nitrogen-containing bisphosphonate (N-BP) would increase mineral content (BMC), volume, mechanical repair. also set out investigate local delivery assess whether exposure could be...
NeuropeptideY-, Y2 receptor (Y2)-, and leptin-deficient mice show similar anabolic action in cancellous bone but have not been assessed cortical bone. Cortical mass is elevated Y2(-/-) through greater osteoblast activity. In contrast, leptin deficiency results reduced mass. We opposing central regulation of bone.Treatment osteoporosis confounded by a lack agents capable stimulating the formation osteoblasts. Recently, brain has identified as potent regulator formation. Hypothalamic or...
Background: Femoral head osteonecrosis as a result of trauma in adolescents has poor prognosis femoral collapse and subsequent degenerative change the hip. There are currently no satisfactory treatments for with this condition, although bisphosphonate therapy improved outcome animal models osteonecrosis. We evaluated following adolescents. Methods: established protocol identifying use bone scans immediately after surgical treatment hips at risk development trauma. In consecutive group...
The new Fassier-Duval Telescopic IM System (FD-rod) has the advantage of a single entry point over traditional telescopic rods such as Bailey-Dubow or Sheffield rods. Although encouraging early results were presented by originators technique at international meetings, there is no formal publication in literature yet.We performed chart and x-ray review first 24 consecutive FD-rod insertions 15 patients (age, 1.5 to 12.5 y) with minimum 1-year follow up (1 2.4 after implantation femoral and/or...
Abstract Background Bone repair is dependent on the presence of osteocompetent progenitors that are able to differentiate and generate new bone. Muscle found in close association with orthopaedic injury, however its capacity make a cellular contribution bone remains ambiguous. We hypothesized myogenic cells MyoD-lineage contribute repair. Methods employed MyoD -Cre + :Z/AP conditional reporter mouse which all permanently labeled human alkaline phosphatase (hAP) reporter. tracked models...
Bone morphogenic proteins (BMPs) can be used in non-unions to replace autograft. BMPs induce osteoblasts and (less well known) also osteoclasts, which turn controlled by a bisphosphonate. In the present study, our aim was improve biological effect of autologous bone graft adding an anabolic BMP, with or without bisphosphonates, open-fracture model prone non-union.Rat femurs were osteotomized fixed intramedullary K-wire. Autograft placed at osteotomy, mixed either saline BMP-7. After 2 weeks,...