A5082473412- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Nanocluster Synthesis and Applications
- Electrospun Nanofibers in Biomedical Applications
- Titanium Alloys Microstructure and Properties
- 3D Printing in Biomedical Research
- Atherosclerosis and Cardiovascular Diseases
- Carbon and Quantum Dots Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Bone Metabolism and Diseases
- Dental materials and restorations
- biodegradable polymer synthesis and properties
- Cellular Mechanics and Interactions
- Tendon Structure and Treatment
- nanoparticles nucleation surface interactions
- Graphene and Nanomaterials Applications
- Plasmonic and Surface Plasmon Research
- Advanced Nanomaterials in Catalysis
- Shoulder Injury and Treatment
- Mesenchymal stem cell research
- ZnO doping and properties
- Surgical Sutures and Adhesives
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
The University of Sydney
2008-2024
Migration Institute of Australia
2023
Indian Institute of Technology Madras
2021
Australian Research Council
2019-2020
Shanghai Ninth People's Hospital
2018
Shanghai Jiao Tong University
2018
UNSW Sydney
2005-2015
Indian Institute of Science Bangalore
2013
Robert Bosch (Australia)
2009
The University of Queensland
2005
Carbon dots (CDs)-based nanoparticles have been extensively explored for biological applications in sensing and bioimaging. However, the major translational barriers to CDs imaging include synthetic strategies obtain monodisperse with tunable structural, electronic, optical properties order achieve high-resolution deep-tissue imaging, intracellular detection, of metal ions high sensitivity down nanomolar levels. Herein, we report a novel strategy synthesize develop multifunctional...
Abstract Calcium silicate (CaSiO 3 ) is regarded as a potential bioactive material. However, its poor chemical stability and cytocompatibility limits biological applications. The aim of this study to incorporate Titanium (Ti) into CaSiO produce ceramic with improved properties. Sphene (CaTiSiO 5 ceramics were prepared by sintering sol–gel‐derived CaTiSiO powder compacts their was assessed measuring the ions released weight loss after soaking in simulating body fluid for 1, 3, 7, 14 days....
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly. The current standard treatment for AMD involves frequent intravitreal administrations therapeutic agents. While effective, this approach presents challenges, including patient discomfort, inconvenience, and risk adverse complications. Nanoparticle-based drug delivery platforms offer promising solution to overcome these limitations. These are engineered target retina specifically control release, which...
Abstract Ca–Si system ceramics, in particular CaSiO 3 are regarded as potential bioactive bone repair/regeneration material. However, their high dissolution rate limits biological applications. The aim of this study was to incorporate Zinc (Zn) into the ceramics produce part (at 10 and 20% Zn) or complete 50% new crystal phase (hardystonite: Ca 2 ZnSi O 7 ) with improved chemical stability cellular activity. Zn–Ca–Si four Zn contents (0, 10, 20, 50%) were successfully prepared by sintering...
Novel Ca-Si-Ti-based sphene (CaTiSiO 5 ) ceramics possess excellent chemical stability and cytocompatibility. The aim of this study was to prepare coating on titanium alloy (Ti-6Al-4V) for orthopaedic applications using the plasma spray method. phase composition, surface interface microstructure, thickness, roughness bonding strength plasma-sprayed were analysed X-ray diffraction, scanning electron microscopy, atomic force microscopy standard mechanical testing American Society Testing...
Abstract Introduction The objective was to evaluate the changes in S100A8 S100A9, and their complex (S100A8/S100A9) cartilage during onset of osteoarthritis (OA) as opposed inflammatory arthritis. Methods S100A9 protein localization were determined antigen-induced arthritis mice, mouse femoral head explants stimulated with interleukin-1 (IL-1), surgically-induced OA mice. Microarray expression profiling all S100 proteins evaluated at different times after initiation degradation explant...
Abstract A photopolymerizable‐tyraminated poly(vinyl alcohol) (PVA‐Tyr) system that has the ability to covalently bind proteins in their native state was evaluated as a platform for cell encapsulation. However, key hurdle this is radicals generated during cross‐linking can cause oxidative stress cells. This research hypothesized incorporation of anti‐oxidative (sericin and gelatin) into PVA‐Tyr gels would mitigate any toxicity caused by radicals. The results showed although 1 wt% sericin...
Surface topography is one of the key factors in regulating interactions between materials and cells. While topographies presented to cells vivo are non-symmetrical complex shapes, current fabrication techniques limited replicate these geometries. In this study, we developed a microcasting technique successfully produced imprinted hydroxyapatite (HAp) surfaces with nature-inspired (honeycomb, pillars, isolated islands) topographies. The vitro biological performance was evaluated using...
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors in world. Currently, there are no approved targeted therapies for PDAC. Mutations Kirsten rat sarcoma viral oncogene homologue (KRAS) known to be a major driver PDAC progression, but it was considered an undruggable target until recently. Moreover, also suffers from drug delivery issues due highly fibrotic tumor microenvironment. In this perspective, we provide overview recent developments targeting mutant KRAS and...
The development of suitable synthetic scaffolds for use as human tendon grafts to repair ruptures remains a significant engineering challenge. Previous have demonstrated suboptimal tissue ingrowth and synovitis due wear particles from fiber-to-fiber abrasion. In this study, we present novel fiber-reinforced hydrogel (FRH) that mimics the hierarchical structure native graft material. Ultrahigh molecular weight polyethylene (UHMWPE) fibers were impregnated with either biosynthetic polyvinyl...
PVA-Tyr hydrogel facilitated covalent incorporation can control release of pristine growth factors while retaining their native bioactivity.