A5100410466- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Genomics and Phylogenetic Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Microbial Community Ecology and Physiology
- Protein Hydrolysis and Bioactive Peptides
- Metabolomics and Mass Spectrometry Studies
- Microbial Inactivation Methods
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Demographic Trends and Gender Preferences
- Plant Molecular Biology Research
- Cancer, Hypoxia, and Metabolism
- Synthesis of β-Lactam Compounds
- Renal and related cancers
- Antimicrobial Resistance in Staphylococcus
- Protist diversity and phylogeny
- S100 Proteins and Annexins
- Lower Extremity Biomechanics and Pathologies
- Pregnancy and preeclampsia studies
- Alzheimer's disease research and treatments
- Cancer therapeutics and mechanisms
- Probiotics and Fermented Foods
- Sports Performance and Training
Jiangsu University
2021-2025
University of Essex
2020-2023
Shanghai Medical College of Fudan University
2023
Zhongshan Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2023
Zhejiang University
2020-2022
Shanghai Clinical Research Center
2022
Nanjing Medical University
2012-2022
Jiangsu Province Hospital
2012-2022
Peking University
2022
Sex differences are known to play a role in disease aetiology, progression and outcome. Previous studies have revealed autosomal epigenetic between males females some tissues, including DNA methylation patterns. Here, we report for the first time an analysis of sex DNAme using Illumina EPIC array human whole blood by performing discovery (n = 1171) validation 2471) analysis.We identified validated 396 sex-associated differentially methylated CpG sites (saDMPs) with majority found be...
DNA methylation (DNAm)-based age clocks have been studied extensively as a biomarker of human ageing and risk factor for age-related diseases. Despite different tissues having vastly rates proliferation, it is still largely unknown whether they at rates. It was previously reported that the cerebellum ages slowly; however, this claim drawn from single clock using relatively small sample size so warrants further investigation. We collected largest DNAm dataset (N = 752) to date. found...
Snow coverage mapping plays a vital role not only in studying hydrology and climatology, but also investigating crop disease overwintering for smart agriculture management. This work investigates snow by learning from Sentinel-2 satellite multispectral images via machine-learning methods. To this end, the largest dataset (to our best knowledge) with three typical classes (snow, cloud background) is first collected labeled semi-automatic classification plugin QGIS. Then, both random...
Abstract Recipients’ age has emerged as a key factor that impacts on acute renal allograft rejection and graft survival. Age-related functional structural changes in the immune system have been observed, yet precise influence of aged immunity kidney transplant remains unclear. In an initial retrospective analysis clinical data gathered from two major centers China Germany, we found correlation between aging mitigated outcomes recipients. To study mechanism, performed transplantation mice...
The inhibition of enhancer zeste homolog 2 (EZH2) has been suggested to be synthetic lethal with polybromo-1 (PBRM1) deficiency, rendering EZH2 an attractive target for the treatment PBRM1 frequently mutated cancers. In current study, we combined computational and biochemical approaches establish efficient system screening validation inhibitors from a large pool chemical compounds. Five putative were identified through structure-based virtual 47,737 compounds analyzed molecular dynamics....
Disturbed intrauterine development increases the risk of renal disease. Various studies have reported that Notch signalling plays a significant role in kidney and diseases. A disintegrin metalloproteinase domain 10 (ADAM10), an upstream protease pathway, is also reportedly involved fibrosis. However, how ADAM10 interacts with pathway causes fibrosis not fully understood. In this study, using prenatal chlorpyrifos (CPF) exposure mouse model, we investigated ADAM10/Notch axis We found...
Abstract Motivation Data normalization is an essential step to reduce technical variation within and between arrays. Due the different karyotypes effects of X chromosome inactivation, females males exhibit distinct methylation patterns on sex chromosomes; thus, it poses a significant challenge normalize data without introducing bias. Currently, existing methods do not provide unbiased solutions data, usually, they just process autosomal chromosomes indiscriminately. Results Here, we...
Sex is an important covariate of epigenome-wide association studies due to its strong influence on DNA methylation patterns across numerous genomic positions. Nevertheless, many samples the Gene Expression Omnibus (GEO) frequently lack a sex annotation or are incorrectly labelled. Considering that imposes patterns, it necessary ensure methods for filtering poor and checking assignment accurate widely applicable.
DNA methylation plays a critical role in the regulation of gene expression. Most studies have been performed herbaceous plants, and little is known about patterns tree genomes. In present study, we generated map methylated cytosines at single base pair resolution for Betula platyphylla (white birch) by bisulfite sequencing combined with transcriptomics to analyze its effects on We obtained detailed view function sequence composition distribution genome B. platyphylla. There are 34,460 genes...
Acute rejection (AR) can lead to allograft dysfunction following renal transplantation, despite immunosuppressive treatments. Accumulating evidence points out a role for epigenetic modification in immune responses. However, the mechanism and contribution of DNA methylation survival remain unclear. In this study, we followed up patients who successively experienced end-stage disease, transplantation with function or dysfunction, hemodialysis. Peripheral blood mononuclear cells were collected...
Abstract BACKGROUND The increase of peptide yield contributed to reducing the usage antibiotics in solid‐state fermented feed. Ultrasound technology is used field liquid‐state fermentation improve products but has not been utilized (SSF). main objective this study was investigate feasibility improving SSF through ultrasound‐treated bacterial strain. RESULTS highest peptides content soybean meal reached 153.28 mg g −1 , which increased by 15.05% compared with control. This value acquired...
Abstract Aims Circulating biomarkers can provide important information for the diagnosis and prognosis of dilated cardiomyopathy (DCM). We explored novel DCM to improve clinical decision‐making. Methods results A total 238 patients 65 control were consecutively enrolled at Zhongshan Hospital between January 2017 2019. In screening set, four controls underwent measurements serum proteomic analysis. Seventy‐six differentially expressed circulating proteins screened by data‐independent...
(E)-Methyl-4-aryl-4-oxabut-2-enoate (YH-8) is a novel PKnB protein kinase inhibitor with good anti-tuberculosis activity. To evaluate its pharmacokinetics in rats, sensitive and selective high performance liquid chromatography–tandem mass spectrometric (LC--MS/MS) method has been developed validated for the quantification of YH-8 rat plasma first time. Samples were pre-treated using liquid--liquid extraction ethyl acetate chromatographic separation was performed on C18 column by gradient...
A direct evaluation of insulin sensitivity on pituitary response to gonadotropin relasing hormone (GnRH) has not been shown in congenital hypogonadotropic hypogonadism (CHH), despite a growing body evidence the association testosterone concentrations with sensitiviy. The objective study was explore whether increased men CHH improve sensitivity, or vice versa.A retrospective at tertiary centre.Series male patients were included from Jannuary 2014 December 2019.Insulin indices calculated oral...
Conclusion. Our data show that temporary appearance of atypical type 1 neurons, like 3 might be another degenerating form spiral ganglion neurons (SGNs); peripherin a marker neurons. Objectives. Further morphological and biochemical studies on surviving SGNs after loss hair cells offer clues for preventing their degeneration. Materials methods. We observed the ultrastructural features analyzed immunoreactivity at 4, 10, or 20 weeks systemic injection neomycin in rats. Results. Type similar...
Abstract Motivation Data normalization is an essential step to reduce technical variation within and between arrays. Due the different karyotypes effects of X chromosome inactivation, females males exhibit distinct methylation patterns on sex chromosomes, thus it poses a significant challenge normalise data without introducing bias. Currently, existing methods do not provide unbiased solutions data, usually, they just process autosomal chromosomes indiscriminately. Results Here, we...
ABSTRACT Sex differences are known to play a role in disease etiology, progression and outcome. Previous studies have revealed autosomal epigenetic between males females some tissues, including DNA methylation patterns. Here, we report for the first time an analysis of sex DNAme using Illumina EPIC array human whole blood (n=1171). We identified 554 sex-associated differentially methylated CpG sites (saDMPs) with majority found be hypermethylated (70%). These saDMP’s enriched islands shores...