Purpose: To estimate the prevalence of dry eye in adult population Bangkok, Thailand. Methods: Five hundred fifty volunteers 40 years age or more who presented to Ramathibodi Hospital for annual examinations were enrolled. Interviewers administered a symptoms questionnaire. Slit-lamp examination and objective assessment consisting tear film breakup time (TBUT), fluorescein corneal staining, Schirmer tests, meibomian gland evaluation performed. Outcome measures included frequency positive...

To evaluate the rate of Sjögren syndrome (SS) in a cohort patients with dry eye syndrome.Medical records primary diagnosis (International Classification Diseases [ICD] code 375.15 or 370.33) were reviewed retrospectively. Patients who had 2 more visits to single center during 2-year period (January 2004 January 2006) considered.Two hundred twenty identified. A total 57 (25.9%) an underlying rheumatic condition: 25 (11.4%) rheumatoid arthritis and 24 (10.9%) (PSS). Majority (96%) carried at...

Human pythiosis is an infectious condition with high morbidity and mortality. The causative agent the oomycete microorganism Pythium insidiosum . pathogen inhabits ubiquitously in a wet environment, direct exposure to initiates infection. Most patients require surgical removal of affected organ, many die from disease. Awareness among healthcare personnel increasing. In this review, we summarized updated information on diagnosis treatment human pythiosis. Vascular ocular are common clinical...

The purpose of this study was to investigate the efficacy and safety topical 100% serum eye drops for corneal epithelial defect after ocular surgery. A total 181 patients who received therapy treatment following several different types surgery were recruited into study. Each patient already failed conventional medical before being prescribed drops. Slit-lamp biomicroscopic examination with fluorescein staining performed at baseline all follow-up visits. main outcome measures rate complete...

To investigate the efficacy and safety of subconjunctival bevacizumab injection for treatment impending recurrent pterygium.A prospective, randomized, single-masked, controlled trial was conducted in 80 patients with pterygium. Patients were randomized into 4 groups using random tables: 20 served as a control received single intralesional 1.25 mg (20 patients, group 1), 2.5 2), or 3.75 3) bevacizumab. Topical 0.1% fluorometholone ocular lubricant administered times daily 1 month all groups....

To develop a mouse model of human chronic dry eye (keratoconjunctivitis sicca [KCS]).Under direct visualization with an operating microscope, CBA/J mice received transconjunctival injection saline or 1.25, 5, 20 milliunits (mU) botulinum toxin B (BTX-B) into the lacrimal gland. The were either left unstressed subjected to air blower for 5 h/d, d/wk in fixed temperature and humidity conditions. Tear production corneal fluorescein staining evaluated all groups before at several time points...

Background Polymorphisms in human leucocyte antigen (HLA) class I genes have been found to be associated with cold medicine (CM)-related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) severe ocular complications (SOC). Because ethnic differences genetic predisposition SJS/TEN among different populations proposed, we focused on Thai patients investigated the association between HLA genotypes CM-SJS/TEN SOC. Methods This multicentre case–control study was conducted...

To report the clinical presentation and role of intrastromal intracameral voriconazole injection in management rare cases fungal keratitis caused by Lasiodiplodia theobromae. Two eyes 2 patients with unresponsive to topical oral antifungal medications were included this study. Diagnosis was confirmed microbiological analysis, including culture-based (case 1 2) DNA sequencing techniques only). The first patient presented multiple satellite lesions one these infiltrates spread deeply into...

Purpose To investigate the prevalence of dry eye disease (DED) and its associated risk factors among Thai university students. Methods A cross-sectional study using an electronic survey was conducted in two Rajabhat universities Bangkok, Thailand. The woman’s health questionnaire used to determine students with DED. DED along 95% confidence interval (CI) were calculated. Logistic regression model identify factors. Results total 4,111 joined completed questionnaires. Mean age 18.8 ± 1.1 years...

The purpose of this study was to report a case contact lens-related Pythium insidiosum corneal ulcer.The authors conducted an interventional report. We the clinical presentations, histopathologic findings, and treatments patient with P. keratitis associated lens wear.A 22-year-old Thai woman presented our clinic nonresponsive, progressive ulcer left eye. Slit lamp examination showed large central measuring 5.4 x 5.2 mm underlying dense stromal infiltrates surrounded by subepithelial...

To evaluate the efficacy and safety of intralesional injection bevacizumab on primary pterygium treatment.In this randomized controlled trial, each patient was to receive either an 2 mg (1 mg/0.04 mL) or a combination topical antihistamine (antazoline HCl 0.05%) vasoconstrictor (tetrahydrozoline 0.04%) as control. The main outcome measurements were symptoms signs (including eye irritation, epiphora, redness, amount discharge, inflammation elevation pterygium, percentage corneal area).A total...

The aim of this study was to investigate the medium-term outcomes after Boston type 1 keratoprosthesis surgery in patients with poor prognosis for standard keratoplasty.A prospective a case series conducted at university-based referral center from 2006 2013. Forty-two eyes 40 minimum follow-up 4 years were recruited. main outcome measures included best spectacle-corrected visual acuity (BSCVA), retention, and complications.The mean 64.9 ± 15.2 months (range, 48-88 months). At week, 90.5% had...

To evaluate the efficacy and outcome of simple limbal epithelial transplantation (SLET) for stem cell deficiency (LSCD) using phenotype detection integrated with clinical manifestation.This prospective multicenter study included patients LSCD who underwent autologous SLET (autoSLET) living-related allogenic (Lr-alloSLET). All were assessed by slit-lamp biomicroscopy, in vivo confocal microscopy (IVCM), impression cytology immunofluorescence staining (ICIF) before after surgery. The criteria...

The 0bjective is to compare treatment effects between undiluted autologous platelet-rich plasma (APRP) and serum (AS) in patients with moderate-to-severe dry eye disease (DED).

To compare the effects of topical dry eye medications including anti-inflammatory agents and lubricant eyedrops for treatment keratoconjunctivitis sicca (KCS) in a botulinum toxin B (BTX-B)-induced mouse model.CBA mice were randomized into 10 groups. The first 5 groups received transconjunctival injection saline lacrimal gland, remaining injected with 0.05 mL 20 mU BTX-B. Each group 0.1% fluorometholone (FML), 0.05% cyclosporine A (CsA), 50:50 combination FML CsA, artificial tears, or 3 days...

Abstract Several studies found that 50–100% serum eye drops provided greater benefits without inducing detrimental effects on the corneal epithelial healing. This study assessed efficacy of undiluted for treatment persistent defects (PED). A total 109 eyes received 100% PED were recruited into this study. The data compared with an historical control group 79 who conventional treatments from 2006–2011 at same institution. Main outcome measures complete healing and incidence adverse events. No...

A retrospective medical record review including 344 patients who were admitted with severe microbial keratitis at Ramathibodi Hospital, Bangkok, Thailand, from January 2010 to December 2016 was conducted. Causative organisms identified in 136 based on positive culture results, pathological reports and confocal microscopy findings. Eighty-six eyes (63.24%) bacterial keratitis, while 50 (36.76%) fungal keratitis. Demographics, clinical history, findings slit-lamp examinations collected. We...

The aim of this study was to compare the effects topical nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroid, doxycycline, and artificial tears for treatment ocular surface damage in Botulinum toxin B (BTX-B)-induced mouse model dry eye.CBA/J mice were randomized into 2 experimental groups 35 animals each. control group received a transconjunctival injection 0.05 mL saline left lacrimal gland, another injected with 20 milliunits BTX-B solution (SPSS, Inc., Chicago, IL). Three (3)...

Purpose . To study the correlation between demographics and clinical variables long-term severe visual impairment in patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). Methods A retrospective chart review of SJS/TEN 2004 2014 was conducted. Demographics, causative agents, ocular manifestations, outcomes were collected. The data analyzed using a multivariate logistic regression model. Results Of 89 including SJS (65, 73.03%), TEN (15, 16.85%), SJS-TEN overlap...

Purpose: To study the etiology and pattern of uveitis in a tertiary ophthalmology center Thailand.Methods: A cross-sectional was conducted on patients presenting to clinic at Ramathibodi Hospital, Thailand, between February 2014 January 2015.Results: total 758 were enrolled into this study. The most common identified cause herpetic (17.2%), followed by Vogt–Koyanagi–Harada disease (13.5%), cytomegalovirus (12.7%), HLA-B27/spondyloarthropathy-associated (12.4%).Conclusions: Herpetic commonest...