A5086726703- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Sesquiterpenes and Asteraceae Studies
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Plant Toxicity and Pharmacological Properties
- Natural Antidiabetic Agents Studies
- Bioactive natural compounds
- Traditional and Medicinal Uses of Annonaceae
- Drug-Induced Hepatotoxicity and Protection
- Plant biochemistry and biosynthesis
- X-ray Diffraction in Crystallography
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Crystallization and Solubility Studies
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- Pharmacological Effects and Toxicity Studies
- Plant chemical constituents analysis
- Chromatography in Natural Products
- Botanical Studies and Applications
- Botany and Plant Ecology Studies
- Free Radicals and Antioxidants
- Psidium guajava Extracts and Applications
University Frères Mentouri Constantine 1
2016-2025
Université Constantine 2
1999-2020
University of Constantine 3
2000-2020
Laboratoire de Chémo-biologie synthétique et thérapeutique
2016
Universidad de La Laguna
2005
Instituto de Productos Naturales y Agrobiología
2004
Universidad de Las Palmas de Gran Canaria
2004
Canary Institute of Cancer Research
2004
Université Paris-Sud
1976
<b>Objective</b> : Toxicity of pesticides is thought to be due reactive oxygen species (ROS). Due their antioxidant property, polyphenols in plant extracts may afford protection from pesticide toxicity. In the present study, we evaluated protective effect a butanolic extract <i>Paronychia argentea </i>L. against toxicity caused by organophosphorus pesticide, chloropyriphos ethyl (CE).<br><b> Materials and Methods</b> Pregnant albino Wistar rats were used. Pesticide administered daily oral...
This study was aimed at determining the phenolic and volatile bioactive components of Senecio massaicus extracts. According to GC–MS results, main constituents petroleum ether extract were 2-(2, 2, 6-trimethylcyclohex-1-enyl) cyclopropane carboxylic acid, methyl ester, (-) caryophyllene oxide, 1-methoxy-3, 5-dimethyl cyclohexene, dihydroactinidiolide. The HPLC–DAD results reported gallic, chlorogenic, caffeic, vanillic, p-coumaric, trans-ferulic, o-coumaric acids as detected acids. n-BuOH...
This study was performed to evaluate the metabolite recovery from different extraction methods applied Thymus algeriensis aerial parts. A high-performance liquid chromatographic method using photodiode array detector with gradient elution has been developed and validated for simultaneous estimation of phenolic compounds in extracts their corresponding purified fractions. The experimental results show that microwave-assisted aqueous 15 min at 100 °C gave most phenolics-enriched extract,...
To investigate the chemical composition of a moderately polar extract (CHCl3 soluble part MeOH-H2O extract) obtained from aerial parts (leaves and flowers) Centaurea diluta Ait. subsp. algeriensis (Coss. & Dur.) Maire, species endemic to Algeria Morocco on which no reports are available date. evaluate in vitro cytotoxic, antifungal antimicrobial activities this cytotoxic its isolated secondary metabolites.The effects were investigated 3 human cancer cell lines i.e. A549 non-small-cell lung...
Oxidative stress is a major cause of drug-induced hepatic diseases and several studies have demonstrated that diet supplementation with plants rich in antioxidant compounds provides variety health benefits these circumstances. Genista quadriflora Munby (Gq) Teucrium polium geyrii Maire (Tp) are known to possess numerous biological properties endemic often used for dietary or medicinal applications. Herein, we evaluated the beneficial effect rich-polyphenol fractions Gq Tp prevent...
Heliotropium bacciferum (Boraginaceae) is a perennial herb, growing in the Bechar region of Algeria, where it traditionally used for skin diseases and tonsillitis. Herein, we report isolation characterization sixteen secondary metabolites from aerial part extracts. They include sterol (1), megastigman type nor-isoprenoids (2, 3, 4, 6, 8, 10), C-11 terpene lactones (5 9), monoterpene (7) chloroform extract (HB-C); glucoside (14), phenolic compounds (11–13, 15, 16) methanol one (HB-M). Their...
Many Helianthemum species (Cistaceae) are recognized for their various medicinal virtues. ruficomum is an endemic to the septentrional Sahara on which no report available so far. The purpose of this work was investigate chemical composition and radical scavenging capacity its isolated components. Collected from Mougheul (south-west Algeria), aerial parts were macerated with 80% EtOH/H₂O, after evaporation, remaining extract diluted H₂O extracted petroleum ether, chloroform, ethyl acetate...
Abstract The leaf oils of Eucalyptus globulus Labill., E. camaldulensis Dehn., gomphocephala A. DC, sideroxylon Cunn. ex Wolls, robusta Smith, tereticomis Smith and viminalis Labill. isolated by steam distillation were analyzed GC/MS. All the species contained α-pinene (2.8–24%), β-pinene (0.2–3.6%), limonene (1.5–4.5%), myrcene (0.1–1.1%), 1,8-cineole (3.5–81%), allo-aromadendrene (0.1–8.8%) globulol (0.2–5.7%) as principal oil components Key Word Index: globules tereticornis...
A new flavone glucoside, apigenin 4'-(6″-methylglucuronide) (1), together with six known compounds, cirsilineol, jaceosidin, melitensin, apigenin, 7-(6″-methylglucuronide) and prunasin, were isolated from the ethanolic extract of aerial parts Centaurea nicaeensis All. var. walliana M. (Asteraceae) collected Souk-Ahras, eastern Algeria. The structures established by spectral analysis, mainly HRESI-MS, UV 2D-NMR experiments (COSY, HSQC HMBC).
Phytochemical research of the aerial parts Centaurea omphalotricha led to isolation three new sesquiterpene lactones, 4'-acetyl cynaropicrin, cebellin F and 15-acetyl dehydromelitensin, together with twelve known compounds, seven two isoprenoids flavonoids. The structures compounds were elucidated by means extensive 1D 2D NMR, MS, comparison reported data in literature. effect lactones on viability human tumor cell lines HL-60 U937 was also investigated 3-acetyl cynaropicrin found be most...
Solid-Liquid Extraction (SLE) using solvent of different polarities (CHCl3, EtOAc, and n-BuOH) has been applied to leaves fruits from (Crataegus oxyacantha L.), a deciduous shrub with an expected rich phytochemical profile. The total polyphenols content the radical scavenging activity each extract were evaluated. These extracts analyzed by HPLC-DAD rutin, quercetin-3-glucoside, caftaric caffeic acid had positively identified. study ethyl acetate C. oxyacantha, led isolation structural...
Background: Pistacia atlantica Desf. (Anacardiaceae) has various applications for dietetic and medicinal purposes. Objective: The aim of the present study was to evaluate antioxidant, antiproliferative anticholinesterase activities different extracts from leaf stem Methods: antioxidant activity performed by four methods: DPPH, ABTS, CUPRAC reducing power assays. Anti-cholinesterase against acetylcholinesterase (AChE) Butyrylcholinesterase (BuChE) enzymes. Antiproliferative assays were...
In this paper we report the isolation and structural elucidation of a new flavonoid (1) three known compounds, 6,8-di-C-methylkaempferol 3-methyl ether (2), oleanolic acid, 2α,3β-dihydroxyurs-12-en-28-oic from aerial parts Eucalyptus occidentalis collected in Algeria. Flavonoids 1 2 were used to study their biological activities on human promyelocytic leukemia cell line, HL-60. Our data show that these compounds induce morphological changes internucleosomal DNA fragmentation characteristic...
Green tea (GT) has been studied for its effects as antioxidant and cancer‐preventive agent. Epidemiological studies showed that GT consumption decreases the risk prostate cancer (PC). To investigate whether erythrocyte oxidative stress (OS) is associated with PC daily of improves phenotype, we performed a study in group Algerian patients, preceded by an vitro to characterize composition antioxidant/antiproliferative activities used. This contained high content phenolic flavonoid compounds,...