A5061622330- Effects and risks of endocrine disrupting chemicals
- Neuroscience and Neuropharmacology Research
- Pharmaceutical studies and practices
- Hypothalamic control of reproductive hormones
- Carcinogens and Genotoxicity Assessment
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Microplastics and Plastic Pollution
- Biochemical effects in animals
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
Neurosciences Paris-Seine
2023
Inserm
2023
Institut de Biologie Paris-Seine
2022-2023
Centre National de la Recherche Scientifique
2023
Sorbonne Université
2023
Université Paris-Seine
2022
Estrogen receptor (ER) α is involved in several estrogen-modulated neural and peripheral functions. To determine its role the expression of female male reproductive behavior, a mouse line lacking ERα nervous system was generated. Mutant females did not exhibit sexual behavior despite normal olfactory preference, had reduced number progesterone receptor-immunoreactive neurons ventromedial hypothalamus. males displayed moderately impaired unaffected fertility, evidences altered organization...
Background: We have previously shown that chronic exposure of adult male mice to low doses di(2-ethylhexyl) phthalate (DEHP) altered sexual behavior and induced down-regulation the androgen receptor (AR) in neural circuitry controlling this behavior. Objectives: The cellular mechanisms by DEHP alone or an environmental mixture were studied. Methods: Two-month-old C57BL/6J males exposed orally for 8 wk (0, 5, 50μg/kg/d) (50μg/kg/d) a mixture. Behavior, dendritic density per 50-μm length,...