Kidney diseases pose a serious healthcare problem because of their high prevalence, worsening patients' quality life, and mortality. Patients with kidney are often asymptomatic until disease progression starts. Expensive renal replacement therapy options, such as dialysis or transplant, required for end-stage disease. Early diagnosis pathology is crucial slowing down curbing further damage. This study aimed to analyze the features protein composition blood plasma in patients most common...

ABSTRACT The proteins expressed during the cell cycle determine function and ensure signaling pathway activation in response to environmental influences. Developments structural biology, biophysics, bioinformatics provide information on structure of particular including that changes due post‐translational modification (PTM) amino acid substitutions (AAS), which is essential for understanding protein life cycle. These are PTMs AASs often modulate alter stability localization a cell. PSSKB...

Advances in the global personalized medicine market are directly related to innovations and developments molecular genetic technologies. This review focuses on key trends development of these technologies healthcare sector. The existing having an impact evolution reviewed. Efficient measures support proposed.

Waste from fish cutting (heads, swim bladders, fins, skin, and bones) is a high-value technological raw material for obtaining substances products with wide range of properties. The possibility using waste the Gadidae family: Alaska pollock (Gadus chalcogrammus) Pacific cod macrocephalus), processed in coastal zone, scientifically substantiated. In this work, technology has been developed processing accumulated order to obtain gelatin, which characterized by high protein content (more than...

Fish species exhibit great diversity rating of aging (from negligible to rapid), which gives a unique possibility for the discovery molecular mechanisms that determine differences in rate aging. A mass spectrometric metabolic profiling skeletal muscle fish with various rates was carried out by direct injection quadrupole time-of-flight spectrometer. The first group includes long-lived (pike (Esox Lucius) and sterlet (Acipenser ruthenus); second group—species gradual senescence such as...

There are a number of different animals that belong to long- and short-lived species show various rate ageing, providing an ideal model investigate mechanisms longevity. In this work, metabolome profiling blood plasma from fishes with ageing rates—negligible (Pike Esox Lucius Sterlet Acipenser ruthenus), gradual (Zander Sander lucioperca Perch Perca fluviatilis) rapid (Chum Salmon Oncorhynchus keta Pink gorbuscha)—was assessed by means direct infusion quadrupole time-of-flight mass...

Ovarian fluid is a mass-production nutritionally valuable byproduct of aquaculture sturgeons. Total antioxidant activity freeze-dried pasteurized and non-pasteurized ovarian Siberian sturgeon ( Acipenser baerii ) was determined to estimate its potential acceptability as an anti-inflammatory anti-age agent in nutraceuticals. using the certified coulometric measurement method. The value total about 18.6 ± 1.1% that well-known source antioxidants – tomato fruits, if calculated by dry weight....

Eggs and larvae of the black soldier fly are a new protein lipid containing component, which seems to be quite promising for inclusion in diet fish feeding, since its rearing makes it possible process wastes from various industries agriculture. Omnivorous natures fly, as well high activity amylases, lipases, proteases also advantageous. The nutritional value eggs reared using fermented milk industry waste substrate was assessed by content total fat, protein, water, macronutrients (K, Ca,...

Waste from fish cutting (heads, swim bladders, fins, skin, bones) is a high-value technological raw material for obtaining substances and products based on them with wide range of properties. The possibility using waste the Gadidae family: Alaska pollock (Gadus chalcogrammus) Pacific cod macrocephalus), processed in coastal zone, scientifically substantiated. In this work, technology has been developed processing accumulated order to obtain gelatin, which characterized by high protein...

The Atlantic cod (Gadus morhua) and red king crab (Paralithodes camtschaticus) processing wastes are massive unutilized in the Murmansk region of Russia. samples skin-containing waste fillets production were hydrolyzed using enzyme preparations derived from hepatopancreases, porcine pancreases, Bacillus subtilis bacteria. activity enzymes hepatopancreases was significantly higher than other sources. optimal conditions hydrolysis process have been figured out. hydrolysate analyzed for amino...

The special advantage of black soldier fly (BSF) (Hermetia illucens) larvae for use as feed is their high protein content and low chitin content, which makes the easier to digest, making them nutritious fish, farm animals birds. It has been reported that BSF contain all amino acids necessary animal protein, including essential acids, also macro- micronutrients. technological parameters hydrolysis procedure were optimized. Some physicochemical hydrolysate yield estimated prepared according...

Introduction. The article explores current trends in the development of information technologies healthcare, as well problems and needs that can be addressed through their implementation. In conclusion, it emphasizes necessity promoting applying healthcare sector for socio-economic development, improvement quality, ensuring universal access to medical services. Purpose. aim this analysis was examine informatics modern society. primary focus on application sector, encompassing aspects such...

The mechanisms of aging differ and have their own features both mammals, in different species groups fish. Telomere length is an indicator the theoretical number cell cycles that cells a particular tissue can go through; therefore, age-related dynamics telomere characterizes changes tissue's ability to regenerate necessary describe mechanism aging. In this work, linear regressions lengths muscle northern pike (Esox lucius) zander (Sander lucioperca) were empirically obtained for wide age...

Physical overexertion surpassing the functional capacity of nervous system causes hyperactivation neural structures cerebellum. In turn, it depletion intracellular resources and progressive structural changes in cerebellar cells fibers. These degenerative may lead to dysfunction, including worsening coordination, balance, motor functions. order maintain health functioning cerebellum general, one needs avoid physical have enough time recover. Three major types Purkinje were identified control...

The high prevalence of schizophrenia worldwide makes it necessary to proceed from subjective assessment patient's clinical symptoms in diagnosis making searching for circulating blood biomarkers. On the one hand, molecular markers and targets therapeutics will make possible refine detail mechanisms pathology development, while on other offer new opportunities elaborating novel approaches disease enhance efficacy timeliness drug therapy.

Background. The article provides the data on global market volume for implantable medical devices and analyzes domestic needs of various branches medicine. Examples international Russian developments are given. Promising directions growing specified. Material methods. authors analyzed information sources considering state device over last 10 years. Conclusion. Implantable have been used in practical healthcare several decades. To date, devices, including new applications, assisted with...