A5101726805- Conducting polymers and applications
- Diabetes Treatment and Management
- Advanced NMR Techniques and Applications
- Pancreatic function and diabetes
- Genetics and Neurodevelopmental Disorders
- Infant Health and Development
- Adenosine and Purinergic Signaling
- Cholesterol and Lipid Metabolism
- Acoustic Wave Resonator Technologies
- Advanced Memory and Neural Computing
- Advanced Battery Materials and Technologies
- Supercapacitor Materials and Fabrication
- Advanced Sensor and Energy Harvesting Materials
- Muon and positron interactions and applications
- Infant Development and Preterm Care
- Genetic Associations and Epidemiology
- Cerebral Palsy and Movement Disorders
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Peroxisome Proliferator-Activated Receptors
- Proteoglycans and glycosaminoglycans research
- Solid-state spectroscopy and crystallography
Aurinia (Canada)
2020-2025
Weill Cornell Medicine
2017
Center for Children
2017
Presbyterian Hospital
2017
Cornell University
2017
National Institutes of Health
2014
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2014
University of British Columbia
2011
University of Akron
2003-2007
We report the synthesis and characterization of a series polyanilines (PANI) that are templated with polymer acid at varying molecular weights. The template choice, poly(2-acrylamido-2-methyl-1-propanesulfonic acid), or PAAMPSA, was synthesized via conventional free-radical polymerization weights ranging from 45 kg mol−1 to 724 mol−1. Subsequent aniline in presence PAAMPSA yielded water-dispersible, conductive PANI–PAAMPSA. electrical conductivity PANI–PAAMPSA increases by approximately...
Data from massively parallel sequencing or ‘Next Generation Sequencing’ of the human exome has reached a critical mass in both public and private databases, that these collections now allow researchers to critically evaluate population genetics manner was not feasible decade ago. The ability determine pathogenic allele frequencies by evaluation full coding sequences merely single nucleotide polymorphism ( SNP ) series SNPs will lead more accurate estimations incidence. For demonstrative...
Kidney injury in patients with lupus nephritis (LN) results pro-fibrotic biomarker expression, a manifestation also observed calcineurin inhibitor (CNI) therapy. The second-generation CNI, voclosporin, is approved the United States and Europe for treatment of active LN combination background immunosuppression, based on successful outcomes from global phase 2 AURA-LV 3 AURORA 1 studies, which demonstrated efficacy voclosporin across diverse racial ethnic populations, encompassing multiple...
The incidence of new onset diabetes after transplant (NODAT) has increased over the past decade, likely due to calcineurin inhibitor-based immunosuppressants, including tacrolimus (TAC) and cyclosporin. Voclosporin (VCS), a next-generation inhibitor, is reported cause fewer incidences NODAT but reason unclear. While signaling plays important roles in pancreatic β-cell survival, proliferation, function, its effects on human β-cells remain understudied. In particular, we do not understand why...
CD44 is expressed on T cells where its ability to bind hyaluronan tightly regulated. Here, we investigated when during an immune response. We found that naïve, murine do not fluoresceinated but are induced upon antigen-induced T-cell activation in vitro and vivo. Hyaluronan binding occurred proliferating the percentage of hyaluronan-binding correlated with strength stimulus. A small persisted after had a memory phenotype (CD122(+) CD44(hi)). This population increased culture IL-7 or IL-15...
Solid state deuteron magic angle spinning nuclear magnetic resonance spectra of conductive ring-deuterated polyaniline consist two peaks, one at the same chemical shift as insulating form polymer and second shifted by 5.8±1 ppm. The magnitude is field temperature independent identified a Knight shift. deuterons undergoing originate from both crystalline amorphous regions sample, implying that conduction mediated delocalized polarons in these regions. Spin count experiments demonstrate highly...
ADVERTISEMENT RETURN TO ISSUECommunication to the...Communication the EditorNEXTAcid Distribution in Phosphonic Acid-Doped Polyaniline by Solid-State NMRTanya L. Young, Jennifer Cross, and Matthew P. EspeView Author Information Department of Chemistry, Knight Chemical Laboratory, University Akron, Ohio 44325 Cite this: Macromolecules 2003, 36, 16, 5891–5893Publication Date (Web):July 10, 2003Publication History Received8 August 2002Published online10 July 2003Published inissue 1...
Abstract Context The incidence of new onset diabetes after transplant (NODAT) has increased over the past decade, likely due to calcineurin inhibitor-based immunosuppressants, including tacrolimus (TAC) and cyclosporin (CsA). Voclosporin (VCS), a next generation inhibitor is reported cause fewer incidences NODAT but reason unclear. Objective Whilst signaling plays important roles in pancreatic β-cell survival, proliferation, function, its effects on human β-cells remain understudied. In...
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