Xiaolu Li

ORCID: 0000-0003-2328-4731
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About
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Research Areas
  • Structural Load-Bearing Analysis
  • Antimicrobial Peptides and Activities
  • Mechanical stress and fatigue analysis
  • Complex Network Analysis Techniques
  • Evaluation Methods in Various Fields
  • Structural Engineering and Vibration Analysis
  • Ionosphere and magnetosphere dynamics
  • Infrastructure Resilience and Vulnerability Analysis
  • Fault Detection and Control Systems
  • Geotechnical Engineering and Underground Structures
  • Composite Structure Analysis and Optimization
  • Human Mobility and Location-Based Analysis
  • Anomaly Detection Techniques and Applications
  • Geophysics and Gravity Measurements
  • Transportation Planning and Optimization
  • Concrete Properties and Behavior
  • Injury Epidemiology and Prevention
  • Erosion and Abrasive Machining
  • Advanced Surface Polishing Techniques
  • Burn Injury Management and Outcomes
  • CCD and CMOS Imaging Sensors
  • Structural Analysis and Optimization
  • Protein Hydrolysis and Bioactive Peptides
  • Probiotics and Fermented Foods
  • Bacterial biofilms and quorum sensing

Luoyang Institute of Science and Technology
2021-2024

Beijing Jiaotong University
2018-2023

Pacific Northwest National Laboratory
2023

Xi'an Jiaotong University
2017-2019

Affiliated Hospital of Southwest Medical University
2017

Sichuan Academy of Traditional Chinese Medicine
2017

Henan Agricultural University
2017

Southwest Hospital
2013-2014

Army Medical University
2013-2014

Abstract: Antibiotic-resistant bacteria present a great threat to public health. In this study, the synergistic effects of antimicrobial peptides (AMPs) and antibiotics on several multidrug-resistant bacterial strains were studied, their azithromycin (AZT)-resistance genes analyzed determine relationships between resistance these effects. A checkerboard method was used evaluate AMPs (DP7 CLS001) (gentamicin, vancomycin [VAN], AZT, amoxicillin) clinical ( Staphylococcus aureus , Pseudomonas...

10.2147/dddt.s107195 article EN cc-by-nc Drug Design Development and Therapy 2017-03-01

ABSTRACT To design and discover new antimicrobial peptides (AMPs) with high levels of activity, a number machine-learning methods prediction have been developed. Here, we present method that can identify novel AMPs are highly similar in sequence to known but offer improved activity along lower host cytotoxicity. Using previously generated AMP amino acid substitution data, developed an contribution matrix contained value for each position the model peptide. A series were designed this method....

10.1128/aac.02823-14 article EN Antimicrobial Agents and Chemotherapy 2014-07-01

Aimed at infinite horizon optimal control problems of discrete time-varying nonlinear systems, in this paper, a new iterative adaptive dynamic programming algorithm, which is the discrete-time policy iteration (DTTV) developed. The law designed to update value function approximates index performance. admissibility analyzed. results show that non-increasingly convergent Bellman-equation solution. To implement neural networks are employed and implementation structure established, avoids...

10.1109/jas.2023.123096 article EN IEEE/CAA Journal of Automatica Sinica 2023-03-01

Vulnerability analysis is the premise of operational risk management and control for large-scale complex urban rail transit network (URTN) under operation interruption important stations. The temporary one station in an emergency may lead to cascading failure paralysis whole URTN due load other stations exceeding limited capacity. priority proposed by combining its location function URTN. In addition, focusing on travel behaviour passengers synergy public transport networks, a novel...

10.1155/2022/2069112 article EN cc-by Journal of Advanced Transportation 2022-04-11

Vulnerability assessment plays a crucial role in the management of complex and large-scale urban rail transit networks (URTNs). Even temporary disruption may paralyze an entire public transportation network under cascading failure. In terms vulnerability URTN, most studies have focused on changes URTN topological characteristics travel costs disturbances, thereby neglecting impact alternative modes passenger flow redistribution within URTN. Therefore, this study, considering redistribution,...

10.1109/access.2020.3047159 article EN cc-by-nc-nd IEEE Access 2020-12-24

With the emergence of all kinds location services applications, massive data are collected in real time. A hierarchical fast density clustering algorithm, DBSCAN(density based spatial applications with noise) algorithm on Gauss mixture model, is proposed to detect clusters and noises arbitrary shape data. First, gaussian model used fit probability distribution dataset determine different levels; then, DBSCAN subdatasets levels locally clustered, at same time, appropriate seeds selected...

10.3390/en12193722 article EN cc-by Energies 2019-09-29

To improve the accuracy and efficiency of fault data identification traffic detectors is crucial in order to decrease probability unexpected failures intelligent transportation system (ITS). Since convolutional recognition based on flow three-parameter law has a poor capability for multiscale data, PCA (principal component analysis) adopted identification. This paper proposes detection models model, MSPCA (multiscale principal model improved respectively. In rate detectors’ combines wavelet...

10.3390/app9173491 article EN cc-by Applied Sciences 2019-08-23

This study aims to investigate the effect of ring plate on mechanical performance X-type tube-gusset joints. The failure modes, ultimate strengths, and mechanisms X-joints with plates were investigated through experiments finite element analyses. results indicated that chord within effective range constituted primary bearing structure X-joint. Increases in thickness width increased strength By considering forces braces as a superposition bending moment force acting gusset X-joint, simplified...

10.1155/2024/6929522 article EN cc-by Advances in Civil Engineering 2024-04-04

Urban rail stations play an important role in passenger distribution and connectivity intervals the network. How to effectively reasonably evaluate their importance network is key optimizing urban structure reducing operational risks. Taking site as research object considering topology, volume, flow correlation of network, index citation used define node metric based on h-index. Furthermore, method calculating degree transit nodes h-index proposed. The validity verified by data Beijing 2016,...

10.3390/app9235189 article EN cc-by Applied Sciences 2019-11-29

Degradation of reinforced concrete (RC) structures due to chloride penetration followed by reinforcement corrosion has been a serious problem in civil engineering for many years. The numerical simulation methods at present are mainly finite element method (FEM) and difference (FDM), which based on mesh. Mesh generation takes long time. In the article, solution transport is analyzed using radial point interpolation (RPIM) element-free Galerkin (EFG). They all meshless methods. RPIM utilizes...

10.12989/cac.2015.16.5.669 article EN Computers and Concrete, an International Journal 2015-11-25

The external radiated noise level of civil aircraft is one the key indicators airworthiness certification. Acquiring acoustic radiation characteristics a prerequisite for optimizing noise. In this paper, large linear microphone array was deployed on ground and C919 flew over along normal direction in different flight states. This paper performed test data analysis methods aircraft. Based measured data, sound field distribution sphere were calculated analyzed. proposed method provides...

10.1117/12.3030300 article EN 2024-06-05

This paper studies the methodologies to regulate output brightness of auto-gated image intensifier by users across diverse illumination settings, in according their specific application scenarios. Firstly, we investigated influencing factors affecting under various conditions, Subsequently, introduced a novel approach: adjusting MCP voltage when falls below its saturation point, otherwise value anode current set. Notably, these two methods can operate independently and collectively...

10.1117/12.3037127 article EN 2024-12-04

In the grey clustering assessment, integrated method can solve problem that there are not distinguished differences of coefficient. This paper proposes an improved based on existing some deficiencies in division value scope cluster coefficients, and proves effectiveness through empirical analysis.

10.4236/ojapps.2017.74012 article EN Open Journal of Applied Sciences 2017-01-01

Fatigue life is a crucial design factor which dictates the safe operation of wind turbines, but it influenced by uncertain factors such as environmental loads, analytical models, material properties, and manufacturing methods. In this study, 1.5 MW turbine was monitored in to understand fatigue mechanism enhance design. The influence different operating conditions on damage analyzed correlating strain monitoring data with supervisory control acquisition (SCADA) data. Furthermore, evaluation...

10.1155/2023/1100725 article EN cc-by Advances in Civil Engineering 2023-08-19

The quantitative calculation and evaluation of seismic damage play a crucial role in ensuring structural safety, conducting performance-based analysis, implementing strengthening measures. However, there is limited research on the performance blind-bolted T-stub steel connections used extensively prefabricated buildings. In this study, tensile sub model connection beam–column joint investigated. influence flange web thickness connector, as well shear-loaded connecting bolts T-stub, are...

10.3390/buildings13102603 article EN cc-by Buildings 2023-10-15

The mechanical properties of sandy soil depend on both the confining pressure and state compactness. Therefore, buried depth tunnel relative density sand are key factors that affect ground deformation induced by tunneling a super-large-diameter shield. In this study, parameters SANISAND constitutive model first calibrated based triaxial test data for Foshan silty fine sand. Then, actual project, two-dimensional finite-element analysis is established to investigate width maximum value...

10.3390/sym15010071 article EN Symmetry 2022-12-27
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