A5061311689- Neurobiology and Insect Physiology Research
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Animal Behavior and Reproduction
- Invertebrate Immune Response Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Cellular transport and secretion
- Antioxidant Activity and Oxidative Stress
- Circadian rhythm and melatonin
- Insect Utilization and Effects
- Axon Guidance and Neuronal Signaling
- Lysosomal Storage Disorders Research
- Neurogenesis and neuroplasticity mechanisms
- Plant Molecular Biology Research
- Insect and Pesticide Research
- Neuroscience and Neuropharmacology Research
- Hippo pathway signaling and YAP/TAZ
University of Birmingham
2023-2024
Pontificia Universidad Católica de Chile
2021-2024
Université Paris Sciences et Lettres
2022
Centre National de la Recherche Scientifique
2022
ESPCI Paris
2022
Parkinson disease (PD) is a common neurodegenerative condition affecting people predominantly at old age that characterized by progressive loss of midbrain dopaminergic neurons and the accumulation α-synuclein-containing intraneuronal inclusions known as Lewy bodies. Defects in cellular degradation processes such autophagy-lysosomal pathway are suspected to be involved PD progression. The mammalian Lysosomal-associated membrane proteins LAMP1 LAMP2 transmembrane glycoproteins localized...
Experience shapes the brain as neural circuits can be modified by stimulation or lack of it. The molecular mechanisms underlying structural circuit plasticity and how modifies behaviour are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns value to stimuli, it also controls behaviour, including locomotion, learning, memory. In Drosophila , Toll receptors ideally placed translate into change. Toll-6 is expressed in dopaminergic neurons (DANs), raising...
Parkinson’s disease (PD) is a neurodegenerative characterized by motor symptoms and dopaminergic cell loss. A pre-symptomatic phase non-motor precedes the onset of alterations. Two recent PET studies in human carriers mutations associated with familial PD demonstrate an early serotonergic commitment—alteration SERT binding—before any or dysfunction, that is, at putative stages. These findings support hypothesis alterations system could contribute to progression PD, idea difficult be tested...
Abstract Background Drosophila melanogaster lipophorin receptors (LpRs), LpR1 and LpR2, are members of the LDLR family known to mediate lipid uptake in a range organisms from humans. The vertebrate orthologs LpRs, ApoER2 VLDL-R, function as glycoprotein involved development central nervous system, Reelin, which is not present flies. VLDL-R associated with hippocampus cerebral cortex, important association areas mammalian brain, well neurodevelopmental neurodegenerative disorders linked those...
Experience shapes the brain, as neural circuits can be modified by stimulation or lack of it. The molecular mechanisms underlying structural circuit plasticity and how modifies behaviour, are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns value to stimuli, it also controls including locomotion, learning memory. In Drosophila , Toll receptors ideally placed translate into brain change. Toll-6 is expressed in dopaminergic neurons (DANs), raising...
Experience shapes the brain as neural circuits can be modified by stimulation or lack of it. The molecular mechanisms underlying structural circuit plasticity and how modifies behaviour are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns value to stimuli, it also controls behaviour, including locomotion, learning, memory. In Drosophila , Toll receptors ideally placed translate into change. Toll-6 is expressed in dopaminergic neurons (DANs), raising...
ABSTRACT Reelin is a secreted glycoprotein with roles in the development of mammalian neocortex, hippocampus and cerebellum. This vertebrate signaling molecule also contributes to adult brain function. Mammalian increases complexity Drosophila Mushroom Body (MB) neurites, an effect mediated by LpR1 LpR2, orthologs receptors. Paradoxically, date, no ortholog has been described . Here, we report that protein product uncharacterized CG17739 gene, which named Drospondin, shares sequence homology...
Experience shapes the brain, as neural circuits can be modified by stimulation or lack of it. The molecular mechanisms underlying structural circuit plasticity and how modifies behaviour, are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns value to stimuli, it also controls including locomotion, learning memory. In Drosophila , Toll receptors ideally placed translate into brain change. Toll-6 is expressed in dopaminergic neurons (DANs), raising...
Cell segregation mechanisms play essential roles during the development of central nervous system (CNS) to support its organization into distinct compartments. The Slit protein is a secreted signal, classically considered paracrine repellent for axonal growth through Robo receptors. However, function in compartmentalization CNS less explored. In this work, we show that and Robo3 are expressed same neuronal population Drosophila optic lobe, where they required correct lobe neuropils by action...
Experience shapes the brain, as neural circuits can be modified by stimulation or lack of it. The molecular mechanisms underlying structural circuit plasticity and how modifies behaviour, are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns value to stimuli, it also controls including locomotion, learning memory. In Drosophila, Toll receptors ideally placed translate into brain change. Toll-6 is expressed in dopaminergic neurons (DANs), raising...
Abstract Background Drosophila melanogaster Lipophorin Receptors (LpRs), LpR1 and LpR2, mediate lipid uptake. The orthologs of these receptors in vertebrates, ApoER2 VLDL-R, bind Reelin, a glycoprotein not present flies. These are associated with the development function hippocampus cerebral cortex, important association areas mammalian brain. It is currently unknown whether LpRs play similar roles Results We report that LpR-deficient flies exhibit impaired olfactory memory sleep patterns,...