A5083740601- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Carcinogens and Genotoxicity Assessment
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- PARP inhibition in cancer therapy
- Radiation Detection and Scintillator Technologies
- Radiation Effects and Dosimetry
- Radioactive contamination and transfer
- Histone Deacetylase Inhibitors Research
- Radioactivity and Radon Measurements
- Nuclear Physics and Applications
- Spaceflight effects on biology
- Boron Compounds in Chemistry
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Anesthesia and Neurotoxicity Research
- Animal Genetics and Reproduction
- Radioactive Decay and Measurement Techniques
- Glioma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Molecular Biology Techniques and Applications
GSI Helmholtz Centre for Heavy Ion Research
2022-2025
iThemba Laboratory
2016-2023
National Research Foundation
2016-2021
Ghent University
2011-2016
Ghent University Hospital
2014-2016
The number of proton therapy facilities and the clinical usage high energy beams for cancer treatment has substantially increased over last decade. This is mainly due to superior dose distribution resulting in a reduction side effects lower integral compared conventional X-ray radiotherapy. More recently, metallic nanoparticles as radiosensitizers enhance radiotherapy receiving growing attention. While this strategy was originally intended radiotherapy, there currently small experimental...
Journal Article The first gamma-H2AX biodosimetry intercomparison exercise of the developing European network RENEB Get access S. Barnard, Barnard * 1Public Health England, Centre for Radiation Chemical and Environmental Hazards, Chilton, UK *Corresponding author: stephen.barnard@phe.gov.uk Search other works by this author on: Oxford Academic PubMed Google Scholar E. A. Ainsbury, Ainsbury J. Al-hafidh, Al-hafidh V. Hadjidekova, Hadjidekova 2National Radiobiology Protection, Sofia, Bulgaria...
Health risks from exposure to low doses of ionizing radiation (IR) are becoming a concern due the rapidly growing medical applications X-rays. Using microarray techniques, this study aims for better understanding whole blood response and high IR.Aliquots peripheral samples were irradiated with 0, 0.05, 1 Gy RNA was isolated prepared gene expression experiments. Bioinformatic approaches, i.e., univariate statistics Gene Set Enrichment Analysis (GSEA) used analyzing data generated. Seven...
Within the EU RENEB project, seven laboratories have taken part in training and harmonisation activities to strengthen triage gamma-H2AX-based radiation exposure assessment. This has culminated a second biodosimetry exercise.Whole blood separated lymphocyte samples were homogenously irradiated with 60Co gamma rays at 0.5, 2.5 (blind samples), 0 2 Gy (reference samples). Following post-exposure incubations of 4 24 h, 16 shipped on ice packs each partner. The stained scored for gamma-H2AX...
Investigation of DNA damage induced by CT x-rays in paediatric patients versus patient dose a multicentre setting. From 51 (median age, 3.8 years) who underwent an abdomen or chest examination one the five participating radiology departments, blood samples were taken before and shortly after examination. was estimated scoring γ-H2AX foci peripheral T lymphocytes. Patient-specific organ tissue doses calculated with validated Monte Carlo program. Individual lifetime attributable risks (LAR)...
Purpose: The European Union's Seventh Framework Programme-funded project 'Multi-disciplinary biodosimetric tools to manage high scale radiological casualties' (MULTIBIODOSE) has developed a multiparametric approach radiation biodosimetry, with particular emphasis on triage of large numbers potentially exposed individuals following accidental exposures. In November 2012, an emergency exercise took place which tested the capabilities MULTIBIODOSE partners. described here had dual purpose:...
Creating a sustainable network in biological and retrospective dosimetry that involves large number of experienced laboratories throughout the European Union (EU) will significantly improve accident emergency response capabilities case large-scale radiological emergency. A well-organised cooperative action involving EU offer best chance for fast trustworthy dose assessments are urgently needed an situation. To this end, EC supports establishment (RENEB). The RENEB project started January...
Global disparities in cancer prevention, detection, and treatment demand a unified international effort to reduce the disease's burden improve outcomes. Despite advances chemotherapy radiotherapy, many tumors remain resistant these treatments. Gold nanoparticles (AuNPs) have shown promise as radiosensitizers, enhancing effectiveness of low-energy X-rays by emitting Auger electrons that cause localized cellular damage. In this study, spherical AuNPs 5 nm 10 were characterized tested on...
With more patients receiving external beam radiation therapy with protons, it becomes increasingly important to refine the clinical understanding of relative biological effectiveness (RBE) for dose delivered during treatment. Treatment planning systems used in clinics typically implement a constant RBE 1.1 proton fields irrespective their highly heterogeneous linear energy transfer (LET). Quality assurance tools that can measure characteristics and quantify or be indicative outcomes become...
Journal Article Is a semi-automated approach indicated in the application of automated micronucleus assay for triage purposes? Get access H. Thierens, Thierens * 1Department Basic Medical Sciences, Ghent University, Building 5B3, De Pintelaan 185, Gent B-9000, Belgium *Corresponding author: hubert.thierens@ugent.be Search other works by this author on: Oxford Academic PubMed Google Scholar A. Vral, Vral C. Vandevoorde, Vandevoorde V. Vandersickel, Vandersickel de Gelder, Gelder Romm, Romm...
A new methodology for assessing linear energy transfer (LET) and relative biological effectiveness (RBE) in proton therapy beams using thermoluminescent detectors is presented. The method based on the different LET response of two lithium fluoride (LiF:Mg,Ti LiF:Mg,Cu,P) measuring charged particles. efficiency detector types was predicted recently developed Microdosimetric d(z) Model combination with Monte Carlo code PHITS. Afterwards, calculated ratio expected correlated fluence- dose- mean...
As hematopoietic stem and progenitor cells (HSPCs) self-renew throughout life, accumulation of genomic alterations can potentially give rise to radiation carcinogenesis. In this study we examined DNA double-strand break (DSB) induction repair as well mutagenic effects ionizing in CD34 T lymphocytes from the umbilical cord newborns. The age dependence damage end points was investigated by comparing newborn with adult peripheral blood lymphocytes. (UCB) contains that are practically all...
Intensity modulated radiotherapy (IMRT) is one of the modern conformal radiotherapies that widely used within context cancer patient treatment. It uses multiple radiation beams targeted to tumor, however, large volumes body receive low doses irradiation. Using γ-H2AX and global genome expression analysis, we studied biological responses induced by ionizing in prostate patients following IMRT. By means different bioinformatics analyses, report IMRT an inflammatory response via induction...
A minority of patients exhibits severe late normal tissue toxicity after radiotherapy (RT), possibly related to their inherent individual radiation sensitivity. This study aimed evaluate four different candidate in vitro cellular radiosensitivity assays for prediction reactions, a retrospective matched case-control set-up breast cancer patients.The population consists expressing (12 cases) and no or minimal reactions controls), with follow-up at least 3 years. Late adverse were evaluated by...
The lack of information on how biological systems respond to low-dose and low dose-rate exposures makes it difficult accurately assess the carcinogenic risks. This is critical importance space radiation, which remains a serious concern for long-term manned exploration. In this study, γ-H2AX foci assay was used follow DNA double-strand break (DSB) induction repair following exposure neutron irradiation, produced as secondary radiation in environment. Human lymphocytes were exposed high (HDR:...
Due to the advantages of charged particles compared conventional radiotherapy, a vast increase is noted in use particle therapy clinic. These include an improved dose deposition and increased biological effectiveness. Metastasis still important cause mortality cancer patients evidence has shown that radiotherapy can formation metastasizing cells. An pathway involved process metastasis Hedgehog (Hh) signaling pathway. Recent studies have demonstrated activation Hh pathway, response X-rays,...