A5089945771- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Advancements in Transdermal Drug Delivery
- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Skin Protection and Aging
- Circadian rhythm and melatonin
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- Orthodontics and Dentofacial Orthopedics
- Adipose Tissue and Metabolism
- Proteins in Food Systems
- Proteoglycans and glycosaminoglycans research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Muscle and Compartmental Disorders
- Biomedical Research and Pathophysiology
- dental development and anomalies
- Pesticide Residue Analysis and Safety
- Electrospun Nanofibers in Biomedical Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Myofascial pain diagnosis and treatment
- Hereditary Neurological Disorders
- Abdominal Surgery and Complications
The University of Texas Southwestern Medical Center
2019-2024
Southwestern Medical Center
2020-2024
Gazi University
1995-2018
Gazi Hastanesi
2018
To assess and compare the roles of plasma urine concentrations neutrophil gelatinase associated lipocalin (NGAL) Cystatin C for early diagnosis septic acute kidney injury (AKI) in adult critically ill patients.Patients were divided into three groups as sepsis-non AKI, sepsis-AKI non AKI. Plasma samples NGAL determined on admission alternate days urinary collected every day until ICU discharge.One hundred fifty one patients studied; 66 63 sepsis-AKI, 22 non-sepsis-non-AKI groups. Although...
The purpose of this study was to determine the dental and skeletal effects facemask therapy, evaluate effect age on treatment response. material consisted lateral cephalometric radiographs 34 subjects with Class III malocclusions treated a Delaire type facemask. Two groups 17 patients each were formed: an early (six girls, 11 boys) late group (eight nine boys). At beginning treatment, mean ages 9 years 8 months for 12 6 group. average time 7 both groups. A control consisting children 5...
Aim: To assess and compare the roles of plasma urine concentrations neutrophil gelatinase associated lipocalin (NGAL) Cystatin C for early diagnosis septic acute kidney injury (AKI) in adult critically ill patients. Methods: Patients were divided into three groups as sepsis-non AKI, sepsis-AKI non AKI. Plasma samples NGAL determined on admission alternate days urinary collected every day until ICU discharge. Results: One hundred fifty one patients studied; 66 63 sepsis-AKI, 22...
The purpose of this study was to examine the role Elovl3 gene in meibogenesis and impact ELOVL3 protein ablation on physiology mouse ocular surface Meibomian glands (MGs). knockout, ELOVL3-ablated (E3hom) mice their wild type littermates (E3wt) were studied side by side. E3hom had abnormal phenotypes such as delayed eye opening, weeping eyes, crusty eyelids, eyelid edema, highly vascularized cornea tarsal plates (TPs), slit eye, increased tearing that resemble symptoms observed human...
Abstract Activated microglia have been implicated in the pathogenesis of age-related macular degeneration (AMD), diabetic retinopathy, and other neurodegenerative neuroinflammatory disorders, but our understanding mechanisms behind their activation is infant stages. With goal identifying novel genes associated with microglial retina, we applied a semiquantitative fundus spot scoring scale to an unbiased, state-of-the-science mouse forward genetics pipeline. A mutation gene encoding E3...
The purpose of this study was to investigate the effect tooth agenesis on dentofacial structures according location absent teeth. A total 74 subjects were classified three main groups and four subgroups Thirteen without selected as control group. All evaluated cephalometrically. As a result it can be concluded that has little structures. Although there statistically significant differences between groups, generally mean values within normal range.
Previous studies on ablation of several key genes meibogenesis related to fatty acid elongation, omega oxidation, and esterification into wax esters have demonstrated that inactivation any them led predicted changes in the meibum lipid profiles caused severe abnormalities ocular surface Meibomian gland (MG) physiology morphology. In this study, we evaluated effects Soat1 were expected cause depletion second largest class lipids (ML)—cholesteryl (CE)—in a mouse model. ML Soat1-null mice...
Abstract Microglia play a role in the pathogenesis of many retinal diseases. Fundus spots mice often correlate with accumulation activated subretinal microglia. Here we use semiquantitative fundus spot scoring scale combination an unbiased, state-of-the-science forward genetics pipeline to identify causative associations between chemically induced mutations and phenotypes. Among several associations, focus on missense mutation Lipe linked increase yellow C57BL/6J mice. −/− generated using...
Abstract Meibum—a lipid secretion that is produced by Meibomian glands (MG) in a process termed meibogenesis—plays critical role ocular surface physiology. Abnormalities the chemical composition of meibum were linked to widespread pathologies—dry eye syndrome (DES) and MG dysfunction (MGD). Importantly, epidemiologic studies Asian population was shown be prone these pathologies more than Caucasian one, which tied differences their meibomian lipids. However, biochemical data support...
The purpose of this study was to investigate the skeletal changes occurring during and after chincap therapy. subjects study, with a mean age 9 years 3 months, consisted 27 patients; all whom possessed an anterior crossbite. Of these patients, 15 had Class III remaining 12 I malocclusions crossbites. applied total force 600 grams treatment period months. were analysed by using linear angular cephalometric measurements. result obtained in investigation that cases, successfully treated...
Background/aim: Pneumoperitoneum with high pressure results in decreased glomerular filtration rates (GFRs). Cystatin-C (Cys-C), neutrophil gelatinase-associated lipocalin (NGAL), and interleukin 18 (IL-18) are new parameters the evaluation of GFR instead creatinine. The aim this study is to show effects pneumoperitoneum on renal function help these acute kidney injury markers. Materials methods: Sixty rats were divided into 10 groups according length time degree achieved during CO2...
Recently, elongase of very long chain fatty acids-3 (ELOVL3) was demonstrated to play a pivotal role in physiology and biochemistry the ocular surface by maintaining proper balance lipid composition meibum. The goal this study further investigate effects ELOVL3 ablation homozygous Elovl3-knockout mice (E3hom) comparison with age sex matched wild-type controls (E3wt). Slit lamp examination mice, histological their tissues, highlighted severe negative impact Elovl3 inactivating mutation on...
Instability of the tear film leads to evaporative dry eye disease (EDED), but Harderian gland in some terrestrial vertebrates may produce novel lipids that stabilize and protect against eye. Here, nonpolar tears rabbit absent human were identified tested preclinical studies determine whether they could treat severe EDED.
Genes Sdr16c5 and Sdr16c6 encode proteins that belong to a superfamily of short-chain dehydrogenases/reductases (SDR16C5 SDR16C6). Simultaneous inactivation these genes in double-KO (DKO) mice was previously shown result marked enlargement the mouse Meibomian glands (MGs) sebaceous glands, respectively. However, exact roles SDRs physiology biochemistry MGs have not been established yet. Therefore, we characterized, for first time, meibum sebum Sdr16c5/Sdr16c6-null using high-resolution MS...
Aim: An ideal biomarker for early diagnosis of septic acute kidney injury (AKI) should reflect renal stress or damage at initiation point, cellular level. The aim this study was to assess the role a urinary cell cycle arrest marker, insulin-like growth factor-binding protein 7 (IGFBP7) in AKI adult critical care patients.Methods: This single-center prospective cohort study. Patients without AKI, admitted medical intensive unit (ICU) between January 2010 and March 2013, were included....
Purpose: Soat1/SOAT1 have been previously reported to be critical for the biosynthesis of cholesteryl esters (CEs) in mouse Meibomian glands (MGs) as loss function led an arrest CE production and a substantial accumulation nonesterified cholesterol meibum, causing increase its melting temperature. The purpose this study was further investigate role Soat1 meibogenesis ocular surface physiology. Methods: features knockout Soat1−/− wild type (WT) mice were studied using various ophthalmic...
Exocrine meibomian glands (MGs) play a central role in the ocular physiology and biochemistry by producing situ and, mostly, de novo secretion (meibum), which is composed of complex mixture homologous lipids various classes, metabolic pathway termed meibogenesis. Recent vivo experiments with number mouse models demonstrated that inactivation any major genes meibogenesis led to alterations lipid composition meibum severe MG abnormalities replicated human pathologies. However, dietary...
The main function of exocrine Meibomian glands (MGs) is to produce a lipid-rich secretion called meibum which plays critical role in maintaining the ocular surface homeostasis humans and most mammals. chemical composition meibum, its quantity produced by MGs, largely determine whether it can fulfill successfully. Aging was frequently associated with onset various MG-related pathologies. goal this study how aging affects mice, identify possible molecular markers aging. Unbiased, untargeted...