A5062116056- Bacterial Genetics and Biotechnology
- Enzyme Structure and Function
- Antibiotic Resistance in Bacteria
- Microbial Metabolic Engineering and Bioproduction
- Bacterial biofilms and quorum sensing
- RNA and protein synthesis mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Protein Structure and Dynamics
- Bacteriophages and microbial interactions
- Drug Transport and Resistance Mechanisms
University of Georgia
2022-2024
University of Oklahoma
2019
is a metabolically robust soil bacterium that employs diverse set of pathways to utilize wide range nutrients. The versatility this microorganism contributes both its environmental ubiquity and rising popularity as bioengineering chassis. In
Pseudomonas aeruginosa encodes eight members of the Rid protein superfamily. PA5339, a member RidA subfamily, is required for full growth and motility P. aeruginosa. Our understanding integration into metabolic network at an early stage, with analyses largely guided by well-established paradigm in Salmonella enterica. A strain lacking has defect minimal glucose medium, both which are exacerbated exogenous serine. All described ridA mutant phenotypes rescued supplementation isoleucine,...
Pseudomonas aeruginosa inhabits diverse environmental niches that can have varying nutrient composition. The ubiquity of this organism is facilitated by a metabolic strategy preferentially utilizes low-energy, non-fermentable organic acids, such as amino rather than the high-energy sugars preferred many other microbes. acid alanine among substrates P. aeruginosa. dad locus encodes constituents catabolic pathway Physiological roles for DadR (AsnC-type transcriptional activator), DadX (alanine...
Abstract Defining the physiological role of a gene product relies on interpreting phenotypes caused by lack, or alteration, respective product. Mutations in critical genes often lead to easily recognized that can include changes cellular growth, metabolism, structure etc. However, mutations many important may fail generate an obvious defect unless additional perturbations are medium genetic background. The latter scenario is exemplified RidA proteins. In vitro proteins deaminate numerous...