A5068295425- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Pancreatic function and diabetes
Yonsei University
2023
Severance Hospital
2023
Sungkyunkwan University
2023
Abstract Liraglutide is a glucagon-like peptide-1 (GLP-1) analog that has been utilized for the treatment of type 2 diabetes mellitus. at higher dose also shows beneficial effects in weight loss, which prompted its widespread use as an anti-obesity drug. The potential liraglutide to treat Alzheimer’s disease and cognitive impairment suggested. Nevertheless, pharmacokinetics liraglutide, including distribution brain, not fully characterized. Therefore, this study aimed develop simple...
Evogliptin (EV) is a novel dipeptidyl peptidase-4 inhibitor (DPP4i) for glycemic control in patients with type 2 diabetes mellitus (T2DM). This study evaluated the pharmacokinetic (PK) and pharmacodynamic (PD) interactions between EV sodium glucose cotransporter-2 inhibitors (SGLT2i) healthy volunteers since combination therapy of DPP4i SGLT2i has been considered as an effective option T2DM treatment. A randomized, open-label, multiple-dose, two-arm, three-period, three treatments,...