BackgroundDue to its rarity, few studies have characterized the epidemiology of male breast cancer. The purpose this study was determine survival and risk factors for cancer in a large U.S. population.MethodsIn study, 19,795 patients with were identified from National Cancer Database (2004–2014). Patient demographics, tumor characteristics treatments analyzed by using descriptive statistics. We used multivariate Cox regression Kaplan Meier analysis.ResultsOver 10 years, incidence increased...

Abstract BACKGROUND: Subcortical injury resulting from conventional surgical management of intracranial hemorrhage may counteract the potential benefits hematoma evacuation. OBJECTIVE: To evaluate safety and a novel, minimally invasive approach for clot evacuation in multicenter study. METHODS: The integrated incorporates 5 competencies: (1) image interpretation trajectory planning, (2) dynamic navigation, (3) atraumatic access system (BrainPath, NICO Corp, Indianapolis, Indiana), (4)...

Conventional approaches to deep-seated cerebral lesions range from biopsy transcortical or transcallosal resection. Although the former does not reduce tumor burden, latter are more invasive and associated with greater potential for irreparable injury normal brain. Disconnection syndrome, hemiparesis, hemianesthesia, aphasia is uncommon after such surgery, especially when lesion large. By contrast, transsulcal parafascicular approach uses naturally existing corridors a tubular retractor...

Background: Despite many studies reporting disparities in coronavirus disease-2019 (COVID-19) incidence and outcomes Black Hispanic/Latino populations, mechanisms are not fully understood to inform mitigation strategies. Objective: The aim was test whether neighborhood factors beyond individual patient-level associated with in-hospital mortality from COVID-19. We hypothesized that the Area Deprivation Index (ADI), a census-block-level composite measure, COVID-19 independently of race,...

OBJECTIVE The move toward better, more effective optical visualization in the field of neurosurgery has been a focus technological innovation. In this study, authors' objectives are to describe feasibility and safety new robotic platform, namely, robotically operated video telescopic-microscope (ROVOT-m), cranial microsurgical applications. METHODS A prospective database comprising patients who underwent procedure between April 2015 September 2016 was queried, first 200 met inclusion...

A study was undertaken to elicit the hidden factors that, when identified, would signal presence of cervical spine instability. Data were derived from records and radiographs 21 patients having sustained traumatic injury lower (C3-C7) who failed a single-stage posterior stabilization procedure necessitating second (or combined) anterior-posterior arthrodesis. Mechanism most frequently identified in this group distraction-flexion (locked facets) pattern (nine patients) "tear drop"...

To report on the preliminary results of preparing and reconstructing pars interarticularis with a cable-screw construct. The success previous techniques to repair defect has been variable.To assess new technique for stabilizing interarticularis, using strongest materials, pedicle screws, cables in bony elements--the lamina.Previous have inadequate structurally stabilize effectively, or were difficult perform. Placing screw across was technically took away from surface area fusion. Scott used...

Although trastuzumab has greatly improved the outcome of HER2-positive breast cancer, emergence resistance hampers its clinical benefits. Trastuzumab is a multi-factorial consequence predominantly due to presence cancer stem-like cells (CSCs). AZD1775, potent anti-cancer agent targeting WEE1 kinase drive tumor with DNA damage premature mitosis, previously shown high efficacies when different cancers well-tolerated cytotoxic profile, but not been evaluated in trastuzumab-resistant (TrR)...

Recent reports have shown that Zika virus (ZIKV) has oncolytic potential against human glioblastoma (GBM); however, the mechanisms underlying its tropism and cell entry are not completely understood. The receptor tyrosine kinase AXL been identified as an for ZIKV in a cell-type-specific manner. Interestingly, is frequently overexpressed GBM patients. Using commercially available lines, we first show cells expressing permissive infection, while do express not. Furthermore, inhibition of using...

Abstract BACKGROUND A number of vertical prolongations the superior longitudinal fasciculus, which we refer to as rami (Vr), arise at level supramarginal gyrus, directed vertically toward parietal lobe. OBJECTIVE To provide first published complete description white matter tracts (WMT) Vr, their relationship intraparietal and parieto-occipital sulci (IPS-POS complex), importance in neurosurgical approaches METHODS Subcortical dissections Vr WMT IPS were performed. Findings correlated with a...

Abstract BACKGROUND The imperative role of white matter preservation in improving surgical functional outcomes is now recognized. Understanding the fundamental framework essential for translating anatomic and literature into practical strategies planning neuronavigation. OBJECTIVE To present a 3-dimensional (3-D) atlas structural scaffolding human matter—ie, “Surgical White Matter Chassis (SWMC)”—that can be used as an organizational tool designing precise individualized trajectory-based...

// George C. Bobustuc 1, 2 , Amin B. Kassam Richard A. Rovin Sheila Jeudy 3 Joshua S. Smith Beth Isley Maharaj Singh Ameya Paranjpe 4 Kalkunte Srivenugopal and Santhi D. Konduri 1 Aurora Research Institute, Milwaukee, WI, USA Neurosciences Innovation Florida Hospital, Orlando, FL, Texas Tech University Health Sciences Center, Amarillo, TX, Correspondence to: Bobustuc, email: George.Bobustuc@aurora.org Konduri, Santhi.Konduri@aurora.org Keywords: MGMT; BG; temozolomide; ER-positive breast...

Individual patient and socioeconomic factors are underexplored prognostic for glioblastoma (GBM). Frailty, a measure of physiological vulnerability, area deprivation, status, easily obtained during the preoperative evaluation. These metrics predictors outcome access to treatments other cancers. Therefore, we sought determine association frailty neighborhood disadvantage with outcomes patients newly diagnosed GBM.This was retrospective review GBM undergoing surgery from 2015 through 2020. The...

Introduction . 5-Aminolevulinic Acid (5-ALA) is a precursor of heme synthesis. A metabolite, protoporphyrin IX (PpIX), selectively accumulates in neoplastic tissue including glioblastoma. Presurgical administration 5-ALA forms the basis fluorescence-guided resection (FGR) glioblastoma (GBM) tumors. However, not all gliomas accumulate sufficient quantities PpIX to fluoresce, thus limiting utility FGR. We therefore developed an assay determine cellular and pharmacological factors that impact...

Studies have shown increased residential greenspace is associated with improved outcome following stroke. This study sought to determine if an independent stroke risk factor.A retrospective 1:4 matched case-control involving 1174 and 4696 control patients over a 3-year period from Milwaukee County, Wisconsin, was conducted. Greenspace determined using normalized difference vegetation index (NDVI) for 250-meter radius surrounding subject's residence. The area deprivation (ADI) the census...

Object In this report the authors review role of bioinformatics in design a research project which molecular genetics malignant glioma were studied. A to characterize Pokemon expression was developed, refined, and implemented using methods. Methods Using resources available from National Center for Biotechnology Information, messenger RNA (mRNA) sequence determined. With information online primer tools, novel primers designed that would specifically amplify mRNA by reverse...

Abstract The use of laser is becoming commonplace in neurological surgery because the potential for surgical precision with minimal surrounding trauma, improved hemostasis, freedom from electrical interference evoked potentials recordings, and a variety other benefits. Despite this enthusiasm, there are little significant data regarding various laser‐neural tissue interactions. Thermal transformation was studied using both carbon dioxide Nd: YAG lasers on rat cerebral cortex. produced...

The hormone leptin has a variety of functions. Originally known for its role in satiety and weight loss, more recently been shown to augment tumor growth cancers. Within gliomas, there is correlation between grade expression receptor. This suggests that autocrine signaling within the microenvironment may promote high-grade gliomas. Leptin does this through stimulation cellular pathways are also advantageous recurrence: antiapoptosis, proliferation, angiogenesis, migration. Conversely, loss...

Abstract BACKGROUND Endoscopic and microneurosurgical approaches to third ventricular lesions are commonly performed under general anesthesia. OBJECTIVE To report our initial experience with awake transsulcal parafascicular corridor surgery (TPCS) of the ventricle its safety, feasibility, limitations. METHODS A total 12 cases reviewed: 6 colloid cysts, 2 central neurocytomas, 1 papillary craniopharyngioma, basal ganglia glioblastoma, thalamic ependymal cyst. Lesions were approached using...