A5080960251- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Photoreceptor and optogenetics research
- Chronic Disease Management Strategies
- Biochemical Analysis and Sensing Techniques
- Insect Utilization and Effects
- Mobile Health and mHealth Applications
- Physical Activity and Health
- Lymphoma Diagnosis and Treatment
- Testicular diseases and treatments
- Radiomics and Machine Learning in Medical Imaging
- Machine Learning in Healthcare
- Diverticular Disease and Complications
- Appendicitis Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
- Artificial Intelligence in Healthcare
- Olfactory and Sensory Function Studies
- Multiple Myeloma Research and Treatments
- Light effects on plants
- COVID-19 diagnosis using AI
- Anorectal Disease Treatments and Outcomes
- Plant and animal studies
Hospital da Luz
2023-2024
Champalimaud Foundation
2014-2022
Food ingestion is one of the defining behaviours all animals, but its quantification and analysis remain challenging. This especially case for feeding behaviour in small, genetically tractable animals such as Drosophila melanogaster. Here, we present a method based on capacitive measurements, which allows detailed, automated high-throughput behaviour. Using this method, were able to measure volume ingested single sips an individual, monitor absorption food with high temporal resolution. We...
To optimize fitness, animals must dynamically match food choices to their current needs. For drosophilids, yeast fulfills most dietary protein and micronutrient requirements. While several metabolites activate known gustatory receptor neurons (GRNs) in Drosophila melanogaster, the chemosensory channels mediating feeding remain unknown. Here we identify a class of proboscis GRNs required for intake. Within this class, taste peg are specifically sustain feeding. Sensillar GRNs, however,...
Background An imaging-based predictor of response could provide prognostic information early during treatment course in patients with multiple myeloma (MM). Purpose To investigate if very changes bone marrow relative fat fraction (rFF) and apparent diffusion coefficient (ADC) histogram metrics, occurring after one cycle induction therapy participants newly diagnosed MM, help predict overall best status. Materials Methods This prospective study included MM who were enrolled between August...
The regulation of feeding plays a key role in determining the fitness animals through its impact on nutrition. Elucidating circuit basis and related behaviors is an important goal neuroscience. We recently used system for closed-loop optogenetic manipulation neurons contingent behavior
Early detection of lung cancer has shown to significantly improve patient survival. Apart from lesion detection, tumour segmentation is critical for developing radiomics signatures. In this work, we propose a novel hybrid approach and on CT scans, where the task assisted by prior regions containing lesions. For task, introduce 2.5D residual deep CNN working in sliding-window fashion, whereas tackled modified U-Net with weighted-dice plus cross-entropy loss. Experimental results LIDC-IDRI...
Abstract Background The benefits of physical activity (PA) and adequate sleep are well documented, their importance strengthens with the increasing prevalence chronic diseases multimorbidity (MM). Interventions to promote that use commercial trackers may be useful non-pharmacological approaches managing individual health; however, limited evidence exists on improve in older adult patients MM. Methods This study aims measure effects behavioral change techniques (BCTs) delivered by a wearable...
Abstract In recent years, most hospitals have implemented Electronic Health Records to manage and integrate a wide range of medical information, including diagnostics, medication admission laboratory test results. Certain variables may serve as indicators patient’s clinical deterioration, making data valuable tool for identifying high-risk patients. This work introduces framework predicting imminent health outcomes (IHO) multimorbidity patients using data. Our cohort includes 322,316 that...
Abstract Background: The benefits of physical activity and adequate sleep are well documented, their importance strengthens with the increasing prevalence chronic diseases multimorbidity (MM). Interventions to promote that use commercial trackers may be useful non-pharmacological approaches managing individual health; however, limited evidence exists on improve in elderly patients MM. Methods: This study aims measure effects behavioral change techniques (BCTs) delivered by a wearable device...
The regulation of feeding plays a key role in determining the fitness animals through its impact on nutrition. Elucidating circuit basis and related behaviors is an important goal neuroscience. We recently used system for closed-loop optogenetic manipulation neurons contingent fly’s behavior to dissect specific subset taste yeast (Steck et al., 2018). Here we describe development validation this system, which term optoPAD. use optoPAD induce appetitive aversive effects by activating or...