A5008359144- Neurobiology and Insect Physiology Research
- Animal Behavior and Reproduction
- Insect and Arachnid Ecology and Behavior
- Zebrafish Biomedical Research Applications
- Physiological and biochemical adaptations
- Photoreceptor and optogenetics research
- Biochemical Analysis and Sensing Techniques
- Insect Utilization and Effects
- CRISPR and Genetic Engineering
- Insect behavior and control techniques
- Genomic variations and chromosomal abnormalities
- Invertebrate Immune Response Mechanisms
- Retinal Development and Disorders
- Neural dynamics and brain function
- Insect symbiosis and bacterial influences
- Light effects on plants
- Alzheimer's disease research and treatments
- Regulation of Appetite and Obesity
- Genetics, Aging, and Longevity in Model Organisms
- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
- Neurological disorders and treatments
Champalimaud Foundation
2018-2023
Universitat Pompeu Fabra
2015-2018
Centre for Genomic Regulation
2015-2018
Boğaziçi University
2012
Sensory navigation results from coordinated transitions between distinct behavioral programs. During chemotaxis in the Drosophila melanogaster larva, detection of positive odor gradients extends runs while negative promote stops and turns. This algorithm represents a foundation for control sensory across phyla. In present work, we identified an olfactory descending neuron, PDM-DN, which plays pivotal role organization turns response to graded changes concentrations. Artificial activation...
The regulation of feeding plays a key role in determining the fitness animals through its impact on nutrition. Elucidating circuit basis and related behaviors is an important goal neuroscience. We recently used system for closed-loop optogenetic manipulation neurons contingent behavior
Foraging animals must balance the costs of exploring their surroundings with potential benefits finding nutritional resources. Each time an animal encounters a food source it decide whether to initiate feeding or continue searching for potentially better options. Experimental evidence and patch foraging models predict that this decision depends on both state density available resources in environment. How brain integrates such internal external states adapt so-called exploration-exploitation...
The LRRC37 gene family maps to a complex region of the human genome and has been subjected multiple rounds segmental duplication. We investigate expression regulation this in tissues organisms show testis-specific mouse but more ubiquitous pattern among primates. Evolutionary phylogenetic analyses support model which new alternative promoters have acquired during primate evolution. identify two promoters, Cl8 particularly Cl3, both are highly active cerebellum fetal brain duplicated from...
Abstract To establish functional connectivity between two candidate neurons that might form a circuit element, common approach is to activate an optogenetic tool such as Chrimson in the pre-synaptic neuron and monitor fluorescence of calcium-sensitive indicator GCaMP post-synaptic neuron. While performing experiments, we found low levels leaky expression can lead strong artifactual signals presumptive postsynaptic even when not intentionally expressed any particular neurons. Withholding all-...
Neuropeptides play a key role in regulating physiology and behavior, including feeding. While animals modify their food choices to respond the lack of specific nutrients, mechanisms mediating nutrient-specific appetites remain unclear. Here, we identified marmite ( mmt ), previously uncharacterized Drosophila melanogaster gene encoding secreted peptide that controls feeding decisions. We show both mutants neuronal knockdown specifically increased intake proteinaceous food, whereas...