A5101857790- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Genetics and Neurodevelopmental Disorders
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular Mechanics and Interactions
- Caveolin-1 and cellular processes
- Acne and Rosacea Treatments and Effects
- Neuroscience and Neural Engineering
- Retinal Diseases and Treatments
- Bee Products Chemical Analysis
- Cell Adhesion Molecules Research
Capital Medical University
2022
Yanbian University Hospital
2018
Institute of Biomedical Science
2014
Secretory carrier membrane protein 5 (SCAMP5), a recently identified candidate gene for autism, is brain specific and highly abundant in synaptic vesicles (SVs), but its function currently unknown. Here, we found that knockdown (KD) of endogenous SCAMP5 by SCAMP5-specific shRNAs cultured rat hippocampal neurons resulted reduction total vesicle pool size as well recycling size, the recycling/resting ratio was significantly increased. KD slowed endocytosis after stimulation, impaired it...
Despite being a highly enriched synaptic vesicle (SV) protein and candidate gene for autism, the physiological function of SCAMP5 remains mostly enigmatic. Here, using optical imaging electrophysiological experiments, we demonstrate that plays critical role in release site clearance at active zone. Truncation analysis revealed 2/3 loop domain directly interacts with adaptor 2, this interaction is its clearance. Knockdown (KD) exhibited pronounced depression accompanied by slower recovery SV...
Baroreceptors are nerve endings located in the adventitia of carotid sinus and aortic arch. They act as a mechanoelectrical transducer that can sense tension stimulation exerted on blood vessel wall by rise pressure transduce mechanical force into discharge endings. However, molecular identity signal transduction from to baroreceptor is not clear. We discovered exogenous integrin ligands, such RGD, IKVAV, YIGSR, PHSRN, KNEED, could restrain pressure-dependent dose-dependent reversible...