A5010060406- Parkinson's Disease Mechanisms and Treatments
- Sleep and related disorders
- Transcranial Magnetic Stimulation Studies
- Sleep and Wakefulness Research
- Extracellular vesicles in disease
- Data Management and Algorithms
- Autoimmune Neurological Disorders and Treatments
- Autophagy in Disease and Therapy
- Acute Ischemic Stroke Management
- Advanced Database Systems and Queries
- Alzheimer's disease research and treatments
- Time Series Analysis and Forecasting
- Sirtuins and Resveratrol in Medicine
- RNA regulation and disease
- Nerve injury and regeneration
- Stroke Rehabilitation and Recovery
- Neurological Disease Mechanisms and Treatments
- Pediatric Pain Management Techniques
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Mobile Health and mHealth Applications
- Barrier Structure and Function Studies
- Botulinum Toxin and Related Neurological Disorders
- Digital Mental Health Interventions
UNSW Sydney
2023-2024
Heilongjiang University of Chinese Medicine
2024
Sir Run Run Shaw Hospital
2020-2023
Zhejiang University
2020-2023
China University of Mining and Technology
2023
Affiliated Hospital of Southwest Medical University
2018-2023
Shanghai Mental Health Center
2021-2022
Shanghai Jiao Tong University
2021-2022
Shanghai Children's Medical Center
2022
Binzhou University
2014-2021
Parkinson’s disease (PD) is a common neurodegenerative in the elderly while pathogenesis remains unclear. We aimed to explore its by plasma integrated metabolomics and proteomics analysis. The clinical data of consecutively recruited PD patients healthy controls were assessed. Fasting samples obtained analyzed using methods. After that, differentially expressed metabolites proteins identified for further bioinformatics No significant difference was found between these two groups....
Amyloid-beta (Aβ) protein is a major component of the extracellular plaque found in brains individuals with Alzheimer's disease (AD). In this study, we investigated effect trans-resveratrol as an antagonist treatment for moderate to mild AD, well its safety and tolerability. This was case–control study that enrolled 30 selected patients who had been clinically diagnosed AD. These were randomly divided into two groups, namely, placebo group (n = 15) received 500 mg orally once daily 52 weeks....
Objective . This study aim to determine changes of serum butyrylcholinesterase (BChE) activity in PD patients and related dementia. Patients Methods Consecutive healthy controls were included clinical data collected. Fast BChE was determined compared between patients. Independent risk factors performed for activity, PD, The relationship disease severity also evaluated. Receiver operating characteristic (ROC) curves obtained explore distinguishing Results Serum mainly independently correlated...
Depression is a common comorbidity in Parkinson's disease (PD) but underdiagnosed. We aim to investigate the altered metabolic pathways of disease-related depression (PDD) plasma and identify potential biomarkers for clinical diagnosis. Consecutive patients with PD were recruited, clinically assessed, PDD identified. Fasting samples collected from 99 differentially expressed metabolites proteins between identified using non-targeted liquid chromatography-mass spectrometry (LC-MS)-based...
Acute infection with Toxoplasma gondii (T. gondii) during pregnancy is associated adverse outcomes. The mechanisms that cause this phenomenon are not clear. Regulatory T cells (Tregs) involved in maternal tolerance, and here we observed a decrease the absolute numbers of CTLA-4+ Tregs PD-1+ spleen at fetal-maternal interface T. gondii-infected mice. Our results suggest induces apoptosis Tregs. Additionally, found expression CTLA-4 PD-1 on were higher than from normal pregnant Therefore,...
In recent years, the evolving of IoT (Internet Things) has resulted in deployment massive numbers sensors various fields, such as Energy and Utility (E&U) industry. These are continuously producing a huge amount time series data, which creates correspondingly demand for data analysis, pattern searching. However, analysis on is currently implemented custom applications, strategy that suffers from low efficiency high maintenance costs. Hence there need to provide service reduces costs enhances...
Abstract Introduction The therapeutic effects of mesenchymal stem cells (MSCs) have been limited by their apoptosis induced oxidative stress after delivery into the injured sites. Therefore, strategies designed to improve MSC efficacy need be explored. Tetramethylpyrazine (TMP) can promote proliferation and differentiation neural cells. In this study, we first evaluated mechanism TMP on H 2 O -stimulated human umbilical cord MSCs (hUCMSCs) then further investigated TMP-stimulated hUCMSCs...