A5082290633- Extracellular vesicles in disease
- RNA regulation and disease
- Parkinson's Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Metabolism and Genetic Disorders
- Nuclear Receptors and Signaling
- Autoimmune Neurological Disorders and Treatments
- Autophagy in Disease and Therapy
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Neuroscience and Neuropharmacology Research
- Ubiquitin and proteasome pathways
- Lysosomal Storage Disorders Research
- Free Radicals and Antioxidants
- Developmental Biology and Gene Regulation
- Sphingolipid Metabolism and Signaling
- Traditional Chinese Medicine Analysis
- Vascular Malformations Diagnosis and Treatment
- Medicinal Plants and Bioactive Compounds
- Medicinal Plants and Neuroprotection
- Peripheral Neuropathies and Disorders
- Wnt/β-catenin signaling in development and cancer
Shanghai First People's Hospital
2021-2025
Shanghai Jiao Tong University
2011-2024
Sir Run Run Shaw Hospital
2012-2022
Zhejiang University
2012-2022
Massachusetts General Hospital
2019
Ruijin Hospital
2011-2012
// YaXing Gui 1 , Hai Liu LiShan Zhang Wen Lv and XingYue Hu Department of Neurology, Sir Run Shaw Hospital, Affiliated with School Medicine, Zhejiang University, Hangzhou, Zhejiang, China Correspondence to: Gui, email: Keywords : Parkinson’s diseases (PD), Alzheimer’s (AD), cerebrospinal fluid (CSF), exosome, microRNA, Pathology Section Received May 24, 2015 Accepted September 30, Published October 19, Abstract The differential diagnosis (PD) is challenging, especially in the...
The 18 kDa translocator protein (TSPO) is a widely used target for microglial PET imaging radioligands, but its expression in post-mortem normal and diseased human brain not well described. We aimed at characterizing the TSPO control (CTRL) Alzheimer's disease (AD) brains. Specifically, we sought to: (1) define cell type(s) expressing TSPO; (2) compare tspo mRNA levels between AD CTRL brains; (3) correlate with quantitative neuropathological measures of reactive glia changes; (4) investigate...
Loss of function mutations Park7/DJ-1 gene increase the susceptibility dopaminergic cells to reactive oxygen species and cause early onset familial Parkinson disease (PD). However, mechanisms underlying neuron loss related DJ-1 mutation remain undefined. Therefore, it is important find new antioxidative functions DJ-1.DJ-1 knockdown knockout mice were used elucidate stress DJ-1. Preliminary study saliva from PD patients controls was confirm our findings obtained above studies.Our experiments...
Amyloid-beta (Aβ) protein is a major component of the extracellular plaque found in brains individuals with Alzheimer's disease (AD). In this study, we investigated effect trans-resveratrol as an antagonist treatment for moderate to mild AD, well its safety and tolerability. This was case–control study that enrolled 30 selected patients who had been clinically diagnosed AD. These were randomly divided into two groups, namely, placebo group (n = 15) received 500 mg orally once daily 52 weeks....
Lotus leaves (LL), petals (LP), and seeds (LS) are believed to have properties that can improve sleep. However, their efficacy in improving sleep has not been fully validated. This study aimed investigate the multitarget mechanisms of extracts from these lotus parts for improvement using chemical analysis, bioactivity assessment, meta‐analysis, network pharmacology evaluation, molecular docking. The components LL, LP, LS were detected ultra‐high‐performance liquid...
Abstract Objectives Our study aimed to investigate the prevalence of cognitive impairment(CI) and associated risk factors among elderly people in Shanghai urban area, China. Methods A population-based survey was conducted aged 55 years or older areas Shanghai. Face-to-face interviews were carried out collect information including demographic characteristics, medical history, medication use, etc. The validated Chinese version Mini-Mental State Examination(MMSE) used screen subjects with CI,...
// YaXing Gui 1 , LiShan Zhang Wen Lv WenMing JinJia Zhao and XingYue Hu Department of Neurology, Sir Run Shaw Hospital, Affiliated with School Medicine, Zhejiang University, Hangzhou, Zhejiang, China Correspondence to: Yaxing Gui, email: Keywords : Parkinson disease, polymorphism, oxidative stress, Gerotarget Received October 21, 2015 Accepted January 24, 2016 Published February 12, Abstract Oxidative stress has been recognized as a risk factor Parkinson's disease (PD) development. We...
Encephalitis mediated by autoantibodies against neuronal antigens and herpes simplex encephalitis (HSE) are seemingly separate causes of encephalopathy in adults. Autoimmune (AE) is autoimmune origin, infectious. The purpose this study was to examine the role cerebrospinal fluid (CSF) exosomes from patients with antibody-positive AE HSE. Towards this, were isolated CSF 13 anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, 11 anti-gamma-aminobutyric acid-B (GABAB) 9 anti-leucine-rich...
Background Mitochondrial DNA polymerase gamma (POLG1) mutations were associated with levodopa-responsive Parkinsonism. POLG1 gene contains a number of common nonsynonymous SNPs and intronic regulatory which may have functional consequences. It is great interest to discover polymorphisms variants Parkinson's disease (PD), both in isolation combination specific SNPs. Materials Methods We conducted case-control study genotyped twenty poly-Q including 344 Chinese sporadic PD patients 154 healthy...
Sleep patterns are more frequently interrupted in patients with Parkinson's disease (PD), and it is still unclear whether genetic factors involved PD-related sleep disorders. In this study, we hypothesize that PD-associated risk affects lipid metabolism, which turn contributes to different types of We used a non-targeted lipidomics explore the composition cerebrospinal fluid (CSF) exosomes derived from PD carrying phospholipase A2 Group VI (PLA2G6) sphingomyelin phosphodiesterase 1 (SMPD1)...