A5010558447- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Tracheal and airway disorders
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Neonatal and Maternal Infections
- Microbial infections and disease research
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Viral gastroenteritis research and epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Long-Term Effects of COVID-19
- Mechanical Circulatory Support Devices
- Parvovirus B19 Infection Studies
- Pleural and Pulmonary Diseases
- IL-33, ST2, and ILC Pathways
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
Chongqing Medical University
2015-2025
Children's Hospital of Chongqing Medical University
2015-2025
China International Science and Technology Cooperation
2025
Chongqing Maternal and Child Health Hospital
2025
Zhongshan Hospital
2018
Fudan University
2018
Boston Children's Hospital
2009-2010
Abstract Background: The objective of this study was to determine the efficacy and safety nebulized 3% hypertonic saline solution salbutamol in treatment mild moderate bronchiolitis. Methods: In a randomized controlled trial, 93 infants with bronchiolitis were divided into two groups. received inhalation 2.5 mg (0.5 mL) dissolved either 4.0 mL normal (0.9%) (control group, n = 43) or (3%) (treatment 50). therapy repeated three times daily until discharge. Cough, wheezing, pulmonary physical...
Objectives To prospectively evaluate prednisolone treatment in children with refractory Mycoplasma pneumonia (MPP). Methods Fifty-eight MPP were enrolled to receive either azithromycin combined (treatment group, n = 28) or alone (control 30). Temperature, respiratory symptoms and signs examined at the time of study entry every 8 hr after enrollment, infiltration absorption, atelectasis resolution, pleural effusion disappearance, serum ferritin LDH levels assessed on seventh day enrollment....
Background Mycoplasma pneumoniae (MP) is a significant cause of community-acquired pneumonia with high macrolide resistance rates. Various COVID-19 pandemic restrictions have impacted the prevalence MP. Objective To assess changes in pattern MP infections among children before, during, and after pandemic. Methods A total 36685 enrolled patients, aged 0-18 years, diagnosed admitted to Children’s Hospital Chongqing Medical University from January 2019 December 2023, were retrospectively...
Background Human bocavirus (HBoV) is a newly discovered parvovirus and increasing evidences are available to support its role as an etiologic agent in lower respiratory tract infection (LRTI). The objective of this study assess the impact HBoV viral load on clinical characteristics children who were positive suffered severe LRTI. Methods Lower aspirates from 186 hospitalized with LRTI obtained by bronchoscopy. HBoVs detected real-time PCR other 10 infectious agents examined using and/or...
Airway epithelial cells constitute the first line of defense against external noxious stimuli and play crucial roles in release inflammatory cytokines (IL33, IL25 TSLP), initiating airway allergic diseases such as asthma. IL33 plays critical physiological processes T2-endotype However, mechanisms by which allergen exposure triggers from remain unclear. Integrated bioinformatic analysis transcriptional bulk RNA-seq single cell (scRNA-seq) data were used to identify core genes determine...
Abstract Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause ST respiratory tract infection (RTI) children. Nasopharyngeal aspirate samples were collected and assessed for common viruses. relationships between virus infections secondary analyzed retrospectively. blood platelet count the presence viruses determined 3156 RTI patients 817 (25.9%) cases ≥500 × 10 9 /L considered as group. Compared normal group, detection rates...
Respiratory syncytial virus (RSV) is one of the most common causes lower respiratory tract infections (LRTI). However, only limited information available regarding its seasonality and relationship with birth month. A retrospective hospital-based study was carried out from June 2009 to May 2019 in Chongqing, southwest China. LRTI cases under 5 years were enrolled this PCR used detect 8 viruses. RSV determined using "average annual percentage" (AAP) "percent positivity" method. total 6991...
EV-D68 is associated with respiratory tract infections (RTIs). Since its first isolation, has been detected sporadically. However, the US and Canada have experienced outbreaks of between August December 2014. This study aimed to investigate molecular epidemiology clinical characteristics in Chongqing, Southwestern China. From January 2012 November 2014, 1876 nasopharyngeal aspirate specimens (NPAs) were collected from hospitalized children RTIs. Among NPAs, was 19 samples (1.0%, 19/1876). Of...
Streptococcus pneumoniae (pneumococcus) is the most common respiratory pathogen worldwide. Nasopharyngeal carriage with S. major source of lower tract infection and horizontal spread among children. Investigating nasopharyngeal crucial for clinicians to control pneumococcus disease. Here, we retrospectively analyzed clinical information 5,960 hospitalized children, focusing on pneumonia children less than five years positive pneumococcal cultures. aspirates (NPAs) were collected between June...
Staphylococcus aureus (S. aureus) is a common cause of bacteremia, which leads to significant morbidity and mortality. We investigated the relationship between time positivity (TTP) clinical outcomes in children with S.aureus bacteremia China. A retrospective study inpatient was performed Children's Hospital Chongqing Medical University China 29 January 2014 August 2017. TTP parameters were determined analyzed. The receiver operating characteristic (ROC) curves plotted for optimal cut-off...
Abstract Background For pediatric pneumonia, the meteorological and air pollution indicators have been frequently investigated for their association with viral circulation but not impact on disease severity. Methods We performed a 10-year prospective, observational study in 1 hospital Chongqing, China, to recruit children pneumonia. Eight commonly seen respiratory viruses were tested. Autoregressive distributed lag (ADL) random forest (RF) models used fit monthly detection rates of each...
Abstract Background Stringent nonpharmaceutical interventions (NPIs) have been implemented worldwide to combat the COVID-19 pandemic, and circulation seasonality of common respiratory viruses subsequently changed. There few multicentre studies or comparisons prevalence accounting for community-acquired pneumonia (CAP) in hospitalized children between pre-COVID period after community school reopening setting zero-COVID policy. Methods We included 1543 with CAP who required hospitalization...
Abstract Background Vitamin A plays a pivotal role in respiratory infection, accurate estimation of vitamin status was recommended planning and implementing interventions. As infections affect serum productions, the real need to be adjusted by acute phase protein (APP). Mycoplasma pneumoniae is an important cause infection children, association between concentrations refractory pneumonia (RMPP) remains unclear. Methods 181 MPP patients were enrolled this retrospective study, other parameters...
Pseudomonas aeruginosa (P. aeruginosa) is a major Gram-negative pathogen, which has been reported to result in high mortality. We aim investigate the prognostic value and optimum cut-off point of time-to-positivity (TTP) blood culture children with P. bacteremia.From August 2014 November 2018, we enrolled inpatients bacteremia 1500-bed tertiary teaching hospital Chongqing, China retrospectively. Receiver operating characteristic (ROC) analysis was used determine TTP, logistic regression were...
Background Regulatory T cells (Treg cells), which are essential for regulation of immune response to respiratory syncytial virus (RSV) infection, promoted by pharyngeal commensal pneumococcus. The effects microflora disruption antibiotics on airway responsiveness and relative responses after RSV infection have not been clarified. Methods Female BALB/c mice (aged 3 weeks) were infected with then treated either oral or double distilled water (ddH2O) from 1 d post (pi). Changes in analyzed...
Delayed antimicrobial therapy is associated with poor outcomes in sepsis, but the optimal antibiotic administration time remains unclear. We aimed to investigate effects of on and evaluate an empirical window for children Streptococcus pneumoniae sepsis. This retrospective study enrolled S. sepsis who presented Children's Hospital Chongqing Medical University from May 2011 December 2018. Classification regression tree (CART) analysis was used determine time-to-appropriate-therapy (TTAT)...