A5085113498- Luminescence Properties of Advanced Materials
- Nanoplatforms for cancer theranostics
- Agriculture and Biological Studies
- Sirtuins and Resveratrol in Medicine
- Computational Drug Discovery Methods
- Renal cell carcinoma treatment
- Cell death mechanisms and regulation
- Toxin Mechanisms and Immunotoxins
- Agricultural Productivity and Crop Improvement
- Berberine and alkaloids research
- Radiation Detection and Scintillator Technologies
- Genetic factors in colorectal cancer
- Autophagy in Disease and Therapy
- Photodynamic Therapy Research Studies
- Renal and related cancers
- Erythrocyte Function and Pathophysiology
- Metabolomics and Mass Spectrometry Studies
- Ginkgo biloba and Cashew Applications
- Animal Nutrition and Health
- Healthcare Systems and Public Health
- Photoacoustic and Ultrasonic Imaging
- Electrohydrodynamics and Fluid Dynamics
- Optical Imaging and Spectroscopy Techniques
- Multiple and Secondary Primary Cancers
- bioluminescence and chemiluminescence research
Saratov State Medical University
2019-2024
Introduction. Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes involved in crucial mechanisms cancer biology, including angiogenesis, cell survival, glucose metabolism, and invasive tumor growth. We aimed to investigate immunohistochemical reaction level HIF-1 multiple primary malignancies kidney prostate compare it with that single tumors these organs. Materials methods. studied 58 archival biopsy samples patients who underwent inpatient treatment at Research...
We have shown experimentally that the interaction of upconversion nanoparticles with erythrocytes leads to changes in cell size and shape. One reasons for this is thought be a change viscosity erythrocyte membrane. Using fluorescent probe, pyrene, we nanoparticle−induced membrane depends on nature nanoparticle shell (cover).
Gratiola officinalis L. (hedge hyssop), a medicinal plant of the Scrophulariaceae family, has diuretic, purgative, and vermifuge properties. It is used as herbal tea to treat chronic gastroenteritis, renal colic, jaundice, intestinal worms. Previously, we have found that an extract from G. nontoxic antitumor, antioxidant, antimicrobial, antiinflammatory, anticachexic, other Our aims in this study were separate into individual fractions, identify most biologically active examine chemical...
(1) Background: Upconversion nanoparticles (UCNPs) are a promising tool for biological tissue structure visualization and photodynamic therapy (PDT). The luminescence of such NPs is excited in the spectrum’s near-infrared (NIR) region, while luminesce visible region. Conjugating with dyes that absorb their makes it possible to increase depth at which PDT performed. (2) Methods: We conducted comprehensive study on possibility using NaYF4:Er:Yb UCNPs vivo imaging PDT. were synthesized by...
Currently, the mortality rate in pediatric population resulted from such diseases as respiratory distress syndrome, pneumonia and infections is extremely high. It cannot be ruled out that this due to impaired functioning of children's immune system. The thymus gland appears central organ immunopoiesis children, why pediatricians pay special attention thymic hyperplasia. To date, there no consensus on nature clinical significance enlargement. aim research was study morphometric parameters...
Objective of the study: We used fluorescence imaging methods apoptosis and necrosis in human renal carcinoma A498 tumor cells vitro to reveal indicated forms cell death under combined effect flavonoid-containing extract Gratiola officinalis cytostatic (cyclophosphamide). Materials methods: The dyes were propidium iodide acridine orange, which “alive dead” test. This test helped us identify total number dead had started, it was characterized by appearance apoptotic bodies or nucleus pyknosis....
The problem of creating antitumor drugs with new mechanisms action that predominantly induce apoptosis is still topical. extract Gratiola officinalis a potential agent containing mainly flavonoids. aim this research to study the effects on activation and autophagy in breast adenocarcinoma SK-BR-3 kidney carcinoma A-498 lines. Apoptotic activity was studied by flow cytofluorometry using Hoechst stain double staining annexin V plus propidium iodide. There 96.3% cells culture late phase...
Background . In recent years, an increase in the incidence of multiple primary malignancies has been observed. Multiple are independent occurrence and development two or more neoplasms different histological origin one patient. Aim To evaluate epidemiological, clinical morphological aspects malignant prostate, kidney, bladder. Materials methods Data analysis work report Saratov region oncological service 2019, presented by Regional Clinical Oncological Dispensary, patient case histories...
The article presents the professional biography of famous scientist-pathologist, Doctor Medicine, Professor Galina Nikiforovna Maslyakova, reflecting her activity as a scientist, teacher and organizer at Saratov State Medical University named after V. I. Razumovsky
The present work demonstrates the assessment of cytotoxicity upconversion nanoparticles (UCNPs) coated by SiO<sub>2</sub> on different normal and cancer murine cell lines in vitro. viability is scored for cytotoxic effects UCNPs at dark conditions. silica shells provide a dose-dependent effect all studied which was most pronounced Raw264.7 line. It probably caused high phagocytic activity macrophages. less sensitive line 4T1. statistically significant differences after 24 48 h incubation...
Carriers based on upconversion nanoparticles (UCNPs) and cyanine dye are suitable for theranostic application in oncology, although care must be taken selection of the surface coating material, UCNP charge, size, dosage material. Investigation influence annealing temperature particles luminescence properties cytotoxic effect relevant. The present work demonstrates assessment cytotoxicity UCNPs unannealed annealed at 550 oC different normal cancer murine cell lines vitro. viability is scored...
Visualization of the spatial distribution nanoparticles in organs and tumors is a rapidly developing field terms diagnostics therapy oncological diseases. The method imaging up-conversion tissues using scanning system has become widespread. In this case, exciting radiation focused on surface object, luminescence collected by wide-aperture optical recorded photodetector. aim study was to register upconversion sections laboratory animals health disease (liver cancer) fluorescent microscope. It...
Background and aim — Gratiola officinalis extract has antimicrobial properties, but its wound healing activity not been described. Material Methods The aqueous solution of dry was used for treatment skin wounds with different routes administration. In the experiment 40 white laboratory male rats weight 150±50 grams were subjected to incised model flat in interscapular region under general anesthesia. A morphological study carried out assess effectiveness therapy administered. Results most...