A5067340229- Trypanosoma species research and implications
- Adenosine and Purinergic Signaling
- Biochemical and Molecular Research
- Mosquito-borne diseases and control
- Malaria Research and Control
University of Cambridge
2018-2020
Recent development of benzoxaborole-based chemistry gave rise to a collection compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), devastating neglected tropical disease. However, further medicinal is largely restricted by lack insight into mechanism action (MoA) pathogenic kinetoplastids. We adopted multidisciplinary approach, combining high-throughput forward genetic screen functional group focused chemical biological,...
Introduced about a century ago, suramin remains frontline drug for the management of early-stage East African trypanosomiasis (sleeping sickness). Cellular entry into causative agent, protozoan parasite Trypanosoma brucei, occurs through receptor-mediated endocytosis involving parasite's invariant surface glycoprotein 75 (ISG75), followed by transport cytosol via lysosomal transporter. The molecular basis trypanocidal activity unclear, but some evidence suggests broad, specific, impacts on...