A5075268222- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Bone Tissue Engineering Materials
- Spinal Cord Injury Research
- 3D Printing in Biomedical Research
- MicroRNA in disease regulation
- Neurological disorders and treatments
- Dyeing and Modifying Textile Fibers
- Vascular anomalies and interventions
- Tissue Engineering and Regenerative Medicine
- Liver physiology and pathology
- Cardiovascular Disease and Adiposity
- Mitochondrial Function and Pathology
- Organ Donation and Transplantation
- Parkinson's Disease Mechanisms and Treatments
- Silk-based biomaterials and applications
- Adipokines, Inflammation, and Metabolic Diseases
- Renal and Vascular Pathologies
- Vitamin D Research Studies
- Axon Guidance and Neuronal Signaling
- Artificial Intelligence in Healthcare
- Pharmacological Effects of Medicinal Plants
- Neuroscience and Neuropharmacology Research
- Coconut Research and Applications
- Saffron Plant Research Studies
All India Institute of Medical Sciences Bhubaneswar
2019-2023
Ben-Gurion University of the Negev
2023
All India Institute of Medical Sciences Rishikesh
2020-2022
IFTM University
2021
National Institute of Ayurveda
2020
Lala Lajpat Rai Memorial Medical College
2020
Indian Institute of Chemical Biology
2014-2018
Ganesh Shankar Vidyarthi Memorial Medical College
2017
Bhabha Atomic Research Centre
2014
All India Institute of Medical Sciences
2004-2013
Axonal regeneration can occur within hours of injury, the first step being formation a new growth cone. For sensory and retinal axons, regenerative ability in vivo correlates with potential to form cone after axotomy vitro . We show that this regenerate depends on local protein synthesis degradation axon. Axotomy leads fourfold sixfold increase 3 H-leucine incorporation both neurones starting 10 min peaking 1 h axotomy. Application inhibitors (cycloheximide anisomycin) cut including axons...
Human hair proteins were isolated and purified for the fabrication of tissue-engineering scaffolds. Their cellular compatibility was studied using NIH3T3 mice fibroblast cells. The characterized FTIR spectroscopy, sodium dodecyl sulfate-polyacrylamide gel electrophoresis molecular weights two-dimensional polyacrylamide their isoelectric points (pIs). keratins in range 40-60 kilo-Daltons (kDa) matrix 15-30 kDa. pIs found to be 4.5-5.3. Sponges formed by lyophilization. Scanning electron...
Abstract The processes activated at the time of axotomy and leading to formation a new growth cone are first step in regeneration, but still poorly characterized. We investigated this event an vitro model performed on dorsal root ganglia retinal explants. observed that ganglion axons cell axons, which had grown out poly d ‐lysine/laminin substrate culture preparation greatly differed their regenerative response after subsequent lesion made far from body. majority adult only small percentage...
Pathophysiology of attention-deficit hyperactivity disorder (ADHD) is not known, and therefore the present study investigated mitochondrial defects, if any in cybrids created from patients control population. To investigate pathology ADHD, cell lines were ADHD probands controls by fusing their platelets with ρ0-cells prepared SH-SY5Y neuroblastoma line. Cellular respiration, oxidative stress, membrane potential morphology evaluated employing oxygraph, mitochondria-specific fluorescence...
Abstract Scaffolds of agar and gelatin were developed using a novel entrapment method where molecules mutually entrapped one another forming stable cell adhesive matrices. Glutaraldehyde was used as crosslinking agent for gelatin. Three types hybrid matrices prepared in different proportions the weight ratio 1:1, 2:1, 3:1. Surface characterization dry scaffolds carried out by scanning electron microscope. Swelling studies phosphate buffer saline (PBS) at physiological pH 7.4. The integral...
Background: Family planning services have the potential to improve quality of lives people and their economic welfare. The objective study was assess level awareness, attitude, current practice different family methods elicit reasons for couples not using any method.Methods: A cross sectional descriptive done among 1050 married women reproductive age .Results: Most were between 21-34 years (60.1%) had primary education (40%).It observed that with increase in education, awareness also...
microRNAs are known to regulate various protein-coding gene expression posttranscriptionally. Fatty acids cell membrane constituents and also influence the biological activities of cells like signal transduction, growth differentiation cells, apoptosis induction, other physiological functions. In our experiments, we used lauric acid analyse its effects on human cancerous lines.Our objective was speculate miRNA profile in treated untreated lines further study metabolic pathways targeted...
Background: Pulse Wave Velocity (PWV) is the propagation speed of wave-induced along aorta and arterial tree, each time heart beats. PWV increases with increased stiffness, thus establishing it as a reliable prognostic marker for cardiovascular morbidity mortality. On other hand, Total Vascular Resistance (TVR) overall resistance offered by systemic circulation pulmonary circulation. This needs to be overcome in order create flow blood through circulatory system. The goal this study was...
Background: Coconut oil is an edible obtained from fresh, mature coconut kernels. Few studies have reported the anticancer role of oil. The fatty acid component directly targets liver by portal circulation and as chylomicron via lymph. However, anti-cancer activity against cancer cells oral yet to be tested. active oil, that responsible for not well understood. In this study, three different oils, Virgin Oil (VCO), Processed (PCO) Fractionated (FCO), were used. Objective: Based on previous...
Agar-gelatin hybrid sponges were used as scaffolds to induce the formation of three-dimensional (3D) spheroids HepG2 cells. Agar and gelatin in 2:1 ratio make films sponges. The cell adhesive properties evaluated by attachment kinetics. growth kinetics cells was studied using MTT assay morphology 3D observed through inverted optical microscopy. liver cell-specific functions terms albumin secretion urea synthesis. Paracetamol a model drug investigate use these preliminary cytotoxicity...
MicroRNAs (miRNA) are small non-coding RNAs that regulate the function of mRNA post-transcriptionally in a tissue-specific manner. miRNA expressions heavily dysregulated human cancer cells through various mechanisms, including epigenetic changes, karyotype abnormalities, and biogenesis defects. miRNAs may act as either oncogenes or tumor suppressors under different conditions. Epicatechin is natural compound found green tea which possesses antioxidant antitumor properties.The objective this...
Dentist can play a significant role in identifying the victims or perpetrators of crime as well disasters. Knowledge about various aspects forensic science dental and related evidences help practitioner assisting civil agencies such cases.To evaluate awareness knowledge odontology among dentists metropolitan tier 2 city.Seven hundred seventy four were included this survey. Questionnaire was designed to assess knowledge, aptitude, status practice odontology. Data analyzed by comparing overall...
Abstract Tachykinin receptor 3 (TACR3) is a member of the tachykinin family and falls within rhodopsin subfamily. As G protein-coupled receptor, it responds to neurokinin B (NKB), its high-affinity ligand. Dysfunctional TACR3 has been associated with pubertal failure anxiety, yet mechanisms underlying this remain unclear. Hence, we have investigated relationship between expression, sex hormones, synaptic plasticity in rat model, which indicated that severe anxiety linked dampened expression...
Summary Aim The objective of the study was to develop regenerative therapy by transplanting varied populations dopaminergic neurons, differentiated from mouse embryonic stem cells ( mES ) in striatum for correcting experimental parkinsonism rats. Methods default 7 days serum‐free media (7D), or enhanced differentiation 7D retinoic acid (7R), neurons enriched manual magnetic sorting (SSEA−) were characterized and transplanted ipsilateral 6‐hydroxydopamine‐induced hemiparkinsonian...
Background: The fetus grows in a sterile womb environment. After birth, the newborn immune system has two immediate hurdles to clear. First suppression of compatible and turn on that can counter antigenic world. underlying mechanism fluctuation by milk microRNAs (miRNAs) be crucial for treatment critical or premature newborn. Methods: We collected fourteen samples each colostrum mature from lactating mothers, four were used microarray analysis, other ten miRNA expression profiling real-time...