A5075724890- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Additive Manufacturing and 3D Printing Technologies
- Periodontal Regeneration and Treatments
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Dental materials and restorations
- Anatomy and Medical Technology
- Bone fractures and treatments
- Electrospun Nanofibers in Biomedical Applications
- Bone and Dental Protein Studies
- Calcium Carbonate Crystallization and Inhibition
- Tissue Engineering and Regenerative Medicine
- Cellular and Composite Structures
- Advanced X-ray Imaging Techniques
- Angiogenesis and VEGF in Cancer
- Craniofacial Disorders and Treatments
- Organ and Tissue Transplantation Research
- Head and Neck Surgical Oncology
- Intracranial Aneurysms: Treatment and Complications
- Facial Trauma and Fracture Management
- Innovations in Concrete and Construction Materials
- Graphene and Nanomaterials Applications
- Oral and Maxillofacial Pathology
Inserm
2016-2024
Oniris
2024
Nantes Université
2022-2024
Montreal General Hospital
2023
RMeS - Regenerative Medicine and Skeleton
2022
Biologie, ingénierie et imagerie pour l'Ophtalmologie
2016-2022
McGill University
2018-2021
Université Claude Bernard Lyon 1
2017-2020
SAnté INgenierie BIOlogie Saint-Etienne
2020
Mines Saint-Étienne
2014-2020
Wear tests of joint prostheses are usually performed using bovine calf serum. The results from different laboratories hardly ever comparable as, for example, the protein concentration and composition serum-based test liquids vary. In addition, viscosity these is similar to that water does not match more viscous synovial fluid. present work was aimed at developing a synthetic fluid as an alternative existing liquids. Improved consistency reproducibility price were required. Hyaluronic acid...
Finding alternative strategies for the regeneration of craniofacial bone defects (CSDs), such as combining a synthetic ephemeral calcium phosphate (CaP) implant and/or active substances and cells, would contribute to solving this reconstructive roadblock. However, CaP's architectural features (i.e., architecture composition) still need be tailored, use processed stem cells (e.g., recombinant human morphogenetic protein 2) drastically limits clinical application approaches. Focusing on...
Injectable bone substitutes (IBS) represent compelling options for regenerative medicine as they can be used to optimally fill a complex defect through minimally invasive intervention.
Current architectural and production limitations prevent the manufacturing standardization design of bioceramics. Such have hindered advances in bone tissue engineering regeneration. In this context, we propose a bioceramic process based on impregnation wax molds produced by additive manufacturing. Hydroxyapatite bioceramics with custom architectures were fabricated to evaluate reliability, robustness, process. Results indicate that preserves phase biocompatibility, permits homogeneous...
Abstract The development of alternatives to vascular bone grafts, the current clinical standard for surgical repair large segmental defects still today represents an unmet medical need. subcutaneous formation transplantable has been successfully achieved in scaffolds axially perfused by arteriovenous loop (AVL) and seeded with marrow stromal cells or loaded inductive proteins. Although demonstrating potential, AVL‐based approaches involve complex microsurgical techniques thus are not...
The reconstruction of massive segmental mandibular bone defects (SMDs) remains challenging even today; the current gold standard in human clinics being vascularized transplantation (VBT). As alternative to this onerous approach, tissue engineering strategies have been widely investigated. However, they displayed limited clinical success, particularly failing address essential problem quick vascularization implant. Although routinely used clinics, insertion intrinsic bioengineered constructs...
Developments in the field of additive manufacturing have allowed significant improvements design and production scaffolds with biologically relevant features to treat bone defects. Unfortunately, workflow generate personalized is source inaccuracies leading a poor fit between implant patients' In addition, are often brittle fragile, uneasing their handling by surgeons, risks fracture during insertion defect. Consequently, we developed organo-mineral cementitious displaying evolutive...
Abstract The local environment and the defect features have made skull one of most difficult regions to repair. Finding alternative strategies repair large cranial defects, thereby avoiding current limitations autograft or polymeric ceramic prostheses constitute an unmet need. In this study, regeneration 8 mm critical‐sized calvarial treated by a monetite scaffold directly placed in preimplanted (either bone transplant subcutaneous pocket) then transplanted within is compared. data reveal...
Abstract Creating transplantable vascular networks (angiosomes) that are fed and drained by vessels large enough to be surgically reconnected is key harnessing the potential of regenerative medicine advancing reconstructive surgical techniques. Currently, only way create a new angiosome nontrivial involves pressurizing vein graft its attachment an artery forming arteriovenous loop (AVL). Material induction venous reported, placement 3D printed microporous monetite scaffold around...
Multidimensional, low dose structural and chemical analysis of CDHA mixed with two different hydrogels achieved by cryo-FIB/SEM tomography in combination cryo-EDS.
Après avoir évoqué l’avenir des biomatériaux de réparation tissus dentaires calcifiés (émail et dentine) en essayant d’être biomimétique même stimuler aux interfaces la régénération dentinaire, nous évoquons dans cet article utilisés pour régénérer les soutien dent, le parodonte qui inclut l’os alvéolaire.
The extensive characterization of tissue mineralization in the context bone regeneration represents a significant challenge, given numerous modalities that are currently available for analysis. Here, we propose workflow comprehensive evaluation new formation using relevant large animal osseous ex vivo explant. A defect (diameter = 3.75 mm; depth 5.0 mm) is created an explanted sheep femoral head and injected with macroporous substitute loaded pro-osteogenic growth factor (bone morphogenetic...
Abstract Causing a large diameter blood vessel to sprout branches and capillary network on demand create new angiosome is key harnessing potential of regenerative medicine advancing reconstructive surgery. Currently this can only be achieved by connecting vein graft an artery microsurgery, the arteriovenous loop technique (AVL). The arterial pressure in thin-walled thought drive remodelling branches, however surgical complexity limits application technique. In study we demonstrate that...
The development of instruments combining multiple characterization and imaging tools drove huge advances in material science, engineering, biology, other related fields. Notably, the coupling SEM with micro-Raman spectrometry (μRaman) provides means for correlation between structural physicochemical properties at surface, while dual focused ion beam (FIB)-scanning electron microscopes (SEMs) operating under cryogenic conditions (cryo-FIB-SEM) allow analysis ultrastructure materials situ...