Although bone formation around and within implants has been intensively studied, the role of pores pore geometry is still debated. Notwithstanding studies reporting components as small a few micrometers ('micropores'), ingrowth believed to only occur in larger than 100 μm ('macropores'). A thorough analysis 10 different porous β-tricalcium phosphate cylinders (Ø: 8 mm; L: 13 mm) implanted for 2–24 weeks an ovine model demonstrates mineralized tissue (MT) 1 μm. This contained calcium...

Layers of the polyelectrolytes poly(allylamine hydrochloride) (PAH, polycationic) and poly(styrene sulfonate) (PSS, polyanionic) are consecutively adsorbed on flat silicon oxide surfaces, forming stable, ultrathin multilayer films. Subsequently, a final monolayer polycationic copolymer poly(L-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) is onto PSS-terminated in order to impart protein resistance surface. The growth each polyelectrolyte layers resulting [PAH/PPS]n(PLL-g-PEG) (n = 1–4)...

Wear tests of joint prostheses are usually performed using bovine calf serum. The results from different laboratories hardly ever comparable as, for example, the protein concentration and composition serum-based test liquids vary. In addition, viscosity these is similar to that water does not match more viscous synovial fluid. present work was aimed at developing a synthetic fluid as an alternative existing liquids. Improved consistency reproducibility price were required. Hyaluronic acid...

Positive effects of irradiation with ultraviolet ( UV ) light or treatment non‐thermal plasma on titanium and zirconia surfaces have been described in various studies. The aim this study was to assess compare the changes physicochemical surface conditions after a short plasmas argon oxygen. Titanium samples moderately rough were treated for 12 min either ‐light oven reactor that generates oxygen argon. Changes assessed by confocal microscopy, dynamic contact angle measurement, X‐ray...

It has been reported in the literature that thermal treatment of calcium phosphate ceramics chemically alters surface composition by evaporation. To predict compositional changes, we have developed a thermodynamic model for evaporation phosphorous species from CPP, TCP, HA, and TetCP. In an open atmosphere, predicts formation layer consisting sequence increasingly phosphate-depleted phases. closed system, atmosphere reaches equilibrium with single-phase layer. verify our model, performed...

Abstract CoCr alloys, in particular MP35N and L605, are extensively used biomedical implants, for example coronary stents. In practice, these alloys present a moderately hydrophobic surface which leads to significant platelet adhesion consequently risk of early thrombosis or in‐stent restenosis. Surface modification implants is known alter their biological performances. this study we focused on the alteration vitro responses human cells contacting surfaces with engineered oxide layers. XPS...

To compare the influence of ultraviolet (UV) irradiation and cold atmospheric pressure plasma (CAP) treatment on surface structure, chemistry, cytocompatibility, cell behavior zirconia in vitro.Zirconia samples (TZ-3YSBE) were treated by UV irradiation, oxygen plasma, or argon for 12 minutes each compared with nontreated samples. Surface analysis was conducted using scanning electron microscopy, roughness analysis, x-ray photoelectron spectroscopy. Cell proliferation, viability, attachment...

Blood-contacting medical implants made of Nitinol and other titanium alloys, such as neurovascular flow diverters peripheral stents, have the disadvantage being highly thrombogenic. This makes use systemic (dual) anti-platelet/anticoagulant therapies inevitable with related risks device thrombosis, bleeding complications. Meeting urgent clinical demand for a less thrombogenic surface, we describe here simple treatment standard, commercially available that renders its surface...

Abstract Silica‐like nanoparticles are produced from four different organosilicon monomers HMDSO, TMDSO, TEOS and TMOS in a continuous non‐equilibrium plasma reactor. The nanoparticle synthesis is studied as function of the process pressure, power, gas velocity,and composition (Ar:O 2 :monomer). morphology, mass production,and chemical formed particlesare investigated. An adapted particle growth model for reactor introduced which explains influence parameters on evolution. morphology...

Abstract Phosphorothionates are anti‐wear lubricant additives and potential replacements for zinc dialkyldithiophosphates. In this study, ball‐on‐disc tests have been carried out combinatorially under extreme pressure (EP) conditions (100–350 MPa at 10 N load). The were performed in oil containing triphenyl phosphorothionates substituted with alkyl chains of different lengths. Imaging, small‐area angle‐resolved X‐ray photoelectron spectroscopy following the tribotest to probe modification,...

To improve temperature durability for autoclaving of SiOx diffusion barrier coatings on polypropylene, plasma polymerized hexamethyldisiloxane (pp-HMDSO) is applied by enhanced chemical vapour deposition as interlayer material and compared with results obtained amorphous hydrogenated carbon–nitrogen (a-C : N H) a-Si C O H interlayers. The influence the O2/HMDSO ratio structure related mechanical oxygen properties investigated fragmentation tests, dilatometry, transmission rate, internal...

To control the selective adhesion of human endothelial cells and serum proteins to bioceramics different compositions, a multifunctional ligand containing cyclic arginine-glycine-aspartate (RGD) peptide, tetraethylene glycol spacer, gallate moiety was designed, synthesized, characterized. The binding this alumina-based, hydroxyapatite-based, calcium phosphate-based demonstrated. conjugation induced decrease in nonselective integrin-selective proteins, whereas enhanced, dependent on...

In case of implant associated infection, preservation is with high failure rates.Therefore, a removal or exchange the most often mandatory for treatment success.Alternatively, under certain conditions, local antibiotic delivery can be applied -preserving implant, using example calcium sulphate as resorbable carrier.In this work, third-body wear on total hip prostheses caused by particles was tested in simulator.Inlays made ultra-high-molecular-weight polyethylene (UHMWPE) and cross-linked...

β-Tricalcium Phosphate (β-TCP), one of the most used bone graft substitutes, may contain up to 5 wt% foreign phase according standards. Typical phases include β-calcium pyrophosphate (β-CPP) and hydroxyapatite (HA). Currently, effect small amounts impurities on β-TCP resorption is unknown. This surprising since a very potent osteoclast inhibitor. The main aim this study was assess β-CPP fractions (<1 wt%) in vitro osteoclastic β-TCP. A minor examine HA physico-chemical properties powders...

Polymer implants are interesting alternatives to the contemporary load-bearing made from metals. Polyetheretherketone (PEEK), a well-established biomaterial for example, is not only iso-elastic bone but also permits investigating surrounding soft tissues using magnetic resonance imaging or computed tomography, which particularly important cancer patients. The commercially available PEEK implants, however, require costly coatings, restricts their usage. As an alternative plasma activation can...

Abstract Wear of ultra-high-molecular weight polyethylene (UHMWPE) in joint implant applications has been shown to increase with cross-shear (CS, i.e., multidirectional sliding) but decrease higher contact pressure (CP). Moreover, structural changes, resulting protrusions, are known occur the surface pin following sliding. However, these phenomena not yet fully understood. In this study, we simultaneously varied CP and CS derive an empirical formula for wear factor as a function parameters....

There is a need for evaluating zirconia surface modifications and their potential impact on the biological response of osteogenic cells. Grit blasted discs were either left untreated or underwent acid alkaline etching. Adhesion differentiation MG63 cells was determined after one week culture. The macro-scaled roughness grit discs, independent treatment, within narrow range only slightly smoother than titanium discs. However, alkaline- acid-etching led to an increase micro-roughness surface....

Human joint prostheses experience wear failure due to the complex interactions between Ultra-High-Molecular-Weight Polyethylene (UHMWPE) and Cobalt-Chromium-Molybdenum (CoCrMo). This study uses classification investigate gradual progressive abrasive mechanisms in UHMWPE. Pin-on-disc tests were conducted under simulated vivo conditions, monitoring using Acoustic Emission (AE). Two Machine Learning (ML) frameworks employed for classification: manual feature extraction with ML classifiers a...