A5051852087- Health and Medical Research Impacts
- Diversity and Career in Medicine
- Cell Adhesion Molecules Research
- Proteoglycans and glycosaminoglycans research
- Mobile Health and mHealth Applications
- Sex and Gender in Healthcare
- Emergency and Acute Care Studies
- Meta-analysis and systematic reviews
- COVID-19 diagnosis using AI
- Glycosylation and Glycoproteins Research
- Trauma and Emergency Care Studies
- Cardiovascular Health and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Protease and Inhibitor Mechanisms
- Ubiquitin and proteasome pathways
- Complement system in diseases
- Musculoskeletal synovial abnormalities and treatments
- Hemodynamic Monitoring and Therapy
- Respiratory viral infections research
- Behavioral Health and Interventions
- SARS-CoV-2 detection and testing
- Shoulder and Clavicle Injuries
- Platelet Disorders and Treatments
- Digital Mental Health Interventions
- Medication Adherence and Compliance
University of Pennsylvania
2014-2025
University of Pennsylvania Health System
2021-2025
California University of Pennsylvania
2023
Children's Hospital of Philadelphia
2021-2022
Although most patients with SARS-CoV-2 infection can be safely managed at home, the need for hospitalization arise suddenly.
Importance A comprehensive lipid panel is recommended by guidelines to evaluate atherosclerotic cardiovascular disease risk, but uptake low. Objective To whether direct outreach including bulk orders with and without text messaging increases screening rates. Design, Setting, Participants Pragmatic randomized clinical trial conducted from June 6, 2023, September at 2 primary care practices an academic health system among patients aged 20 75 years least 1 visit in the past 3 who were overdue...
The current coronavirus 2019 (COVID-19) pandemic has prompted a multitude of public health response measures including social distancing, school cancellations, and cessation organized sports.To examine the impact COVID-19 corresponding on characteristics common pediatric musculoskeletal injuries associated with sports.Cohort study; Level evidence, 3.This was multicenter retrospective cohort study comparing patients sports presenting to 3 geographically diverse level I trauma hospitals...
Platelet endothelial cell adhesion molecule‑1 (PECAM‑1) is expressed on the vascular endothelium and has been implicated in late progression of metastatic tumors. The activity PECAM‑1 appears to be mediated by modulation tumor microenvironment (TME) promotion proliferation, rather than through stimulation angiogenesis. present study aimed extend those initial findings indicating that presence functional promotes a proliferative phenotype vivo, as well (B16‑F10 melanoma 4T1 breast cancer...
Women are underrepresented across most surgical specialties and especially in the field of orthopaedic surgery. Despite pediatric surgery being one gender diverse subspecialties orthopaedics, women may still face barriers to academic advancement. Research presentations at national meetings publication record important drivers advancement The aim this study is assess whether research abstracts authored by less likely be published than men.Abstracts from podium given Pediatric Orthopaedic...
Women are underrepresented across the field of orthopedic surgery and may face barriers to academic advancement. Research presentation at national meetings publication record important drivers advancement in surgery. However, little is known regarding potential gender differences after conference research presentation. This investigation analyzed presentations Annual Meeting American Academy Orthopaedic Surgeons 2016 2017. Author was determined through a search institutional professional...
We describe the design, implementation, and validation of an online, publicly available tool to algorithmically triage patients experiencing severe acute respiratory syndrome coronavirus (SARS-CoV-2)-like symptoms.We conducted a chart review who completed subsequently contacted our institution's phone hotline assess tool- clinician-assigned codes, patient demographics, SARS-CoV-2 (COVID-19) test data, health care utilization in 30 days post-encounter. calculated percentage concordance...
Platelet endothelial cell adhesion molecule (PECAM-1) has been implicated in angiogenesis through processes that involve stimulation of motility. Previous studies suggest PECAM-1 tyrosine phosphorylation mediates the recruitment and then activation phosphatase SHP-2, which turn promotes turnover focal adhesions extension filopodia, critical to While these have PECAM-1-dependent signaling PECAM-1-mediated motility, involvement ligand binding migration is undefined. Therefore investigate role...
To reduce atherosclerotic cardiovascular disease (ASCVD) risk, the American College of Cardiology/American Heart Association recommends routinely assessing traditional risk factors and calculation 10-year ASCVD for adults 40-75 years age 20-39 at least every 4-6 years. For many patients, can’t be calculated due to a missing comprehensive lipid panel. In our health system, 23% adult patients had not labs within past 5 We aim evaluate effect behavioral economic interventions on screening...
Although PECAM‐1 is able to mediate homophilic or heterophilic ligand binding, the roles of these interactions in PECAM‐1‐dependent cell motility have not been determined. Mutants mouse (MP) which (MPΔHom) (MPΔHet) binding are disabled by targeted mutations extracellular domain molecule were generated and expressed REN cells (an endothelial surrogate). The resulting cells, along with wild type controls, assessed for localization at intercellular junctions wound‐induced tyrosine...
PECAM‐1, a sialylated cell surface molecule expressed on endothelial cells (ECs), has been implicated in both EC motility and angiogenesis. Neuraminidase 1 (NEU1) sialidase inhibits wound‐induced migration disrupts vitro tube formation though PECAM‐1‐desialylation. The mechanisms by which desialylation of PECAM‐1 its activity are undefined. effects function mediated the binding to other molecules (homophilic) or non‐PECAM‐1 (heterophilic), such as heparin/heparan sulfate glycosaminoglycan...
Ligand interactions between PECAM‐1 and heparan sulfate proteoglycans have been implicated in the ability of to promote cell motility by stimulating Cdc42 activation extension filopodia. However, endothelial proteoglycan(s), involved these activities are undefined. We therefore investigated potential involvement syndecans (SDCs), a family four surface proteoglycans, PECAM‐1‐dependent processes. For studies, we employed HUVEC REN cells (an EC surrogate) expressing mouse (REN‐MP). both types,...
Background: The Pediatric Orthopaedic Society of North America (POSNA) is a leading organization focused on disseminating research and promoting high-quality pediatric orthopaedic care. purpose our study was to understand how quality in surgery has evolved over time by evaluating trends clinical evidence design podium presentations given at POSNA annual meetings from 2011-2020. Methods: Podium presentation abstracts for all 2011-2020 were independently reviewed number patients, single-center...