A5087240150- Near-Field Optical Microscopy
- Advanced Fluorescence Microscopy Techniques
- Optical Coherence Tomography Applications
- Photonic and Optical Devices
- Optical Coatings and Gratings
- Advanced optical system design
- Photoacoustic and Ultrasonic Imaging
- Integrated Circuits and Semiconductor Failure Analysis
- Digital Holography and Microscopy
- Optical measurement and interference techniques
- Corrosion Behavior and Inhibition
- Photonic Crystals and Applications
- Nanofabrication and Lithography Techniques
- Advanced Fiber Optic Sensors
- Advanced Measurement and Metrology Techniques
- Conservation Techniques and Studies
- Adaptive optics and wavefront sensing
- Plasmonic and Surface Plasmon Research
- Advanced Biosensing Techniques and Applications
- Electrowetting and Microfluidic Technologies
- Non-Destructive Testing Techniques
- Advanced MEMS and NEMS Technologies
- Cutaneous Melanoma Detection and Management
- Advanced X-ray Imaging Techniques
- Advanced Surface Polishing Techniques
Centre National de la Recherche Scientifique
2015-2024
Photonics Bretagne (France)
2024
Université de Strasbourg
2017-2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2017-2023
CEA Marcoule
2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2016-2023
Institut National des Sciences Appliquées de Strasbourg
2020-2023
École Polytechnique Fédérale de Lausanne
2021
Franche-Comté Électronique Mécanique Thermique et Optique - Sciences et Technologies
2014-2019
CEA Paris-Saclay
2016-2019
Abstract Label‐free super‐resolution (LFSR) imaging relies on light‐scattering processes in nanoscale objects without a need for fluorescent (FL) staining required super‐resolved FL microscopy. The objectives of this Roadmap are to present comprehensive vision the developments, state‐of‐the‐art field, and discuss resolution boundaries hurdles that be overcome break classical diffraction limit label‐free imaging. scope spans from advanced interference detection techniques, where...
Abstract Microsphere-assisted microscopy currently benefits from a considerable interest in the microscope-research community. Indeed, this new imaging technique enables lateral resolution of optical microscopes to reach around λ /5 through full-field and far-field acquisition while being label-free. Despite photonic jet clearly not relevant concept justify super-resolution phenomenon, we show here how it can be used predict formation performance such as image position microsphere...
In the present work, we have investigated combination of a superresolution microsphere-assisted 2D imaging technique with low-coherence phase-shifting interference microscopy. The performance this is studied by numerical simulation in terms magnification and lateral resolution as function geometrical optical parameters. results simulations are compared experimental measurements reference gratings using Linnik configuration. Additional also shown on nanostructures. An improvement factor 4.7...
We propose an experimental method in microsphere-assisted interference microscopy that makes it possible to reconstruct surface topographies as much with high quantitative depth accuracy when the transversal feature sizes are smaller than classical diffraction limit. The full-field super-resolution microscope consists not only of one glass microsphere object arm but also a second similar reference arm. By compensating sphere aberrations two arms, spatial resolution appears be considerably...
This paper presents a simple method based on the measurement of 3D intensity point spread function for quality evaluation high numerical aperture micro-optical components. The different slices focal volume are imaged thanks to microscope objective and standard camera. Depending optical architecture, it allows characterizing both transmissive reflective components, which either imaging part or component itself moved along axis, respectively. can be used measure length, Strehl ratio,...
Microsphere‐assisted microscopy allows the limit of diffraction light to overcome while being non‐invasive, full‐field, label‐free, and easy‐to‐implement. However, observation translucent samples remains difficult using a classical bright‐field illumination. In this work, method is presented for inspection quasi‐transparent sub‐diffraction‐limited structures by dark‐field illumination in transmission mode. Glass‐imprint features, having size 250 nm, as well fixed mouse brain cells have been...
Summary White‐light microsphere‐assisted microscopy is a full‐field and label‐free imaging promising technique making it possible to achieve subdiffraction lateral resolution. However, performance of this depends not only on the geometrical parameters but also illumination conditions optical system. In present work, experimental measurements computer simulations have been performed in air order determine influence two diaphragm apertures Köhler arrangement spectral width light source both...
Through rigorous electromagnetic simulations, the natural coupling of high-spatial-frequency evanescent waves from near field to far by dielectric microspheres is studied in air. The generation whispering gallery modes inside shown independently any resonance. In addition, conversion mechanism these into propagating analysed. This latter point leads key information that allows a better physical understanding super-resolution phenomenon microsphere-assisted microscopy where...
This paper presents the study of a fabrication technique lenses arrays based on reflow glass inside cylindrical silicon cavities. Lenses whose sizes are out microfabrication standards considered. In particular, case high fill factor is discussed in detail since proximity between generates undesired effects. These effects, not experienced when sufficiently separated so that they can be considered as single items, corrected by properly designing Complete topographic well optical...
Nanoscale materials are nowadays widely used in many different modern technologies. Special attention is thus required for their characterization order to optimize fabrication processes. However, current systems which can achieve nanometric resolution over a large area and three dimensions few. Classical optical microscopy presents resolving power limited by diffraction, making impossible the visualization of elements with size under half wavelength. Recently, several methods have been...
Microsphere-assisted microscopy is a sub-diffraction-limited imaging technique, which uses dielectric microspheres to collect the near-field information of an object. In this work, bulk classical microsphere-based system reduced by simple introduction ball lens. The miniaturized has been designed and vertically assembled. Performance proposed dual-sphere quantified through numerical simulations experiments. A theoretical impulse response with full width at half maximum smaller than...
The presented paper shows the concept and optical design of an array-type Mirau-based OCT system for early diagnosis skin cancer. basic sensor is a full-field, full-range coherence tomography (OCT) sensor. micro-optical interferometer array in Mirau configuration key element allowing parallel imaging multiple field views (FOV). focuses on performance single channel illumination array. In addition straylight analysis this given.
This Letter presents, to our knowledge, the first direct measurement of three-dimensional distribution photonic jets (PJs) generated by shaped-tip multimode optical fibers. A PJ at distal end fibers makes it easier scan a sample, for lithography or analysis, example, with spot smaller than diffraction limit. The backscattered light can also be easily collected. In this study, volume has been reconstructed using stack image planes and compared numerical simulations. For time, power...
The authors review some of the latest results a new high resolution optical metrology technique using small glass microspheres placed on sample to enhance lateral in microscopy. Experimental are shown 2D images gratings and microelectronic structures. simulations experimental measurements for imaging through show an increase magnification 3–5 times as 100 nm air. also 3D different nanostructures that have successfully been incorporated into Mirau Linnik type interferometers. Results grooves...
We present a micromachined vertical scanner with array of suspended 'spider-type' micromirrors which is key component multi-channel 'active' Mirau microinterferometer. The microscanner provides for the displacement reference implementation phase shifting technique. Vertical comb-drive structures are employed actuation (displacement range hundreds nm at 500 Hz) as well in situ capacitive sensing. Integration micro-opto-electro-mechanical microscanners handheld interference microscope has...
The loss of the information, due to diffraction and evanescent waves, limits resolving power classical optical microscopy. In air, lateral resolution an microscope can approximated at half wavelength using a low-coherence illumination. Recently, several methods have been developed in order overcome this limitation and, 2011, new far-field full-field imaging technique was proposed where sub-diffraction-limit has achieved transparent microsphere. article, phenomenon super-resolution...
In the rigorous electromagnetic simulation of an imaging system, evanescent waves from a point source or sample are naturally mixed with propagative waves. Therefore, their contributions difficult to distinguish. We present point-source model made only To illustrate its potential, is applied study evanescent-wave contribution in microsphere-assisted microscopy (MAM). The microsphere process clearly demonstrated. However, we also show that this not enough justify super-resolution. destructive...
Based on diffraction theory and the propagation of light, Fourier optics is a powerful tool allowing estimation visible-range imaging system to transfer spatial frequency components an object. The analyses systems can thus be performed performance retrieved. For better understanding optical study, we present short introduction review mathematical treatment depending illumination conditions system. Furthermore, resolution criteria based are detailed. Also, impact aberrations quality discussed.
This Letter reports on the fabrication of glass lens doublets arranged in arrays and realized at wafer level by means micro-fabrication. The technique is based accurate vertical assembly separately fabricated arrays. Since each one these obtained melting silicon cavities, employed as a spacer order to build well-aligned robust optical module. It shown that performance achieved doublet better than for single equivalent numerical aperture, thanks lower aberrations. has good potential match...
Full field optical coherence tomography (FF-OCT) enables high-resolution in-depth imaging within turbid media. In this work, we present a simple approach which combines FF-OCT with off-axis interferometry for reconstruction of en-face images. With low spatial and temporal illumination, method is able to extract an image from only one interference acquisition. This described, the proof-of-concept demonstrated through observation scattering samples such as organic ex vivo biomedical samples.
We report a simple method, based on intensity measurements, for the characterization of wavefront and aberrations produced by micro-optical focusing elements. This method employs setup presented earlier in [Opt. Express 22, 13202 (2014)] measurements 3D point spread function, which basic phase-retrieval algorithm is applied. combination allows retrieval generated element and, addition, quantification optical through decomposition with Zernike polynomials. The requires only an in-motion...
OCT instruments permit fast and non-invasive 3D optical biopsies of biological tissues. However, they are bulky expensive, making them only affordable at the hospital thus, not sufficiently used as an early diagnostic tool. Significant reduction system cost size is achieved by implementation MOEMS technologies. We propose active array 4x4 Mirau microinterferometers where reference micro-mirrors carried a vertical comb-drive microactuator, enabling phase-shifting technique that improves...