A5036818418- Viral Infections and Vectors
- Mosquito-borne diseases and control
- interferon and immune responses
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Escherichia coli research studies
- Uterine Myomas and Treatments
- RNA and protein synthesis mechanisms
- Microbial Natural Products and Biosynthesis
- Abdominal Surgery and Complications
- Circular RNAs in diseases
- RNA modifications and cancer
- Circadian rhythm and melatonin
- Amoebic Infections and Treatments
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Ovarian cancer diagnosis and treatment
- Infections and bacterial resistance
- Extracellular vesicles in disease
- Organometallic Complex Synthesis and Catalysis
- HIV Research and Treatment
- Bacterial Infections and Vaccines
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
Stanford University
2020-2024
The First People’s Hospital of Lianyungang
2024
First Affiliated Hospital of Soochow University
2023
Soochow University
2023
National University of Singapore
2022
Hebei Medical University
2021
Duke-NUS Medical School
2017
Duke University
2015-2016
National Eye Institute
2013-2014
National Institutes of Health
1997-2014
Cyclic GMP-AMP synthetase (cGAS) is a DNA-specific cytosolic sensor, which detects and initiates host defense responses against microbial DNA. It thus curious that recent study identified cGAS as playing important roles in inhibiting positive-sense single-stranded RNA (+ssRNA) viral infection, especially since not known to activate cGAS. Using dengue virus serotype 2 (DENV-2) vaccine strain (PDK53), we show infection creates an endogenous source of DNA infected cells through the release...
The production of outer membrane vesicles by Gram-negative bacteria has been well documented; however, the mechanism behind biogenesis these remains unclear. Here a high-throughput experimental method and systems-scale analysis was conducted to determine vesiculation values for whole genome knockout library Escherichia coli mutant strains (Keio collection). resultant dataset quantitatively recapitulates previously observed phenotypes implicates nearly 150 new genes in process vesiculation....
The development of live viral vaccines relies on empirically derived phenotypic criteria, especially small plaque sizes, to indicate attenuation. However, while some candidate successfully translated into licensed applications, others have failed safety trials, placing vaccine a hit-or-miss trajectory. We examined the determinants phenotype in two dengue virus (DENV) candidates, DENV-3 PGMK30FRhL3, which produced acute febrile illness recipients, and DENV-2 PDK53, has good clinical profile....
The Maf-family leucine zipper transcription factor NRL is essential for rod photoreceptor development and functional maintenance in the mammalian retina. Mutations are associated with human retinopathies, loss of Nrl mice leads to a cone-only retina complete absence rods. Among highly down-regulated genes Nrl(-/-) retina, we identified receptor expression enhancing protein 6 (Reep6), which encodes member family proteins involved shaping membrane tubules transport G-protein coupled receptors....
The four dengue viruses (DENVs) have evolved multiple mechanisms to ensure its survival. Among these is the ability regulate replication rate, which may contribute avoiding premature immune activation that limit infection dissemination: DENVs associated with epidemics shown slower rate than pre-epidemic strains. Correspondingly, wild-type replicate more slowly their clinically attenuated derivatives. To understand how ‘make haste slowly’, we generated and screened for DENV2 mutants...
Background and Aims: Many studies have shown a link between physical activity (PA) nonalcoholic fatty liver disease (NAFLD). However, more research is needed to investigate the relationship different types of PA NAFLD. This study aimed explore potential PA, hepatic steatosis, fibrosis. Study: A cross-sectional was conducted using data set from National Health Nutrition Examination Survey (NHANES) 2017 2020. multiple linear regression model used examine controlled attenuation parameter (CAP),...
Double recycling amplification for multiplexed detection of serum exosomal microRNAs.
This study was to investigate the changes in gut microbiota maintenance hemodialysis patients and analyze their impact on patient's microinflammation status. For this purpose, thirty-nine chronic kidney disease (CKD) admitted our hospital from March 2019 2022 were selected as experimental group, 40 healthy individuals with examination results during same period control group. The levels of (Lactobacillus, Bifidobacterium, Escherichia coli, Enterococcus faecalis) indicators [interleukin-6...
The ribosomal protein L9 (RPL9), a component of the large subunit ribosome, has an unusual structure, comprising two compact globular domains connected by α-helix; it interacts with 23 S rRNA.To obtain information about rpL9 Ailuropoda melanoleuca (the giant panda), we designed primers based on �nown mam-, mam-we mammalian nucleotide sequence.RT-PCR and PCR strategies were employed to isolate cDNA gene from A. melanoleuca; these sequenced analyzed.We overexpressed in Escherichia coli...
Uterine leiomyosarcoma (uLMS) is a rare, aggressive gynecologic malignancy affecting 1 in 200,000 women. uLMS frequently recurs within the peritoneal cavity, which may result from tumor rupture or surgical morcellation. Current standard of care includes cytoreductive surgery (CRS) and systemic chemotherapy, although recurrence rates are high. This prospective phase II trial aims to investigate safety efficacy heated intraperitoneal chemotherapy (HIPEC) using gemcitabine followed by...
Abstract Background Abnormal proliferation of vascular smooth muscle cells (VSMCs) contributes to remodeling diseases. Recently, it has been discovered that tRNA-derived small RNAs (tsRNAs), a new type non-coding RNAs, are related the and migration VSMCs. tsRNAs regulate target gene expression through miRNA-like function. This study aims explore potential in human aortic cell (HASMC) proliferation. Methods High-throughput sequencing was performed analyze tsRNA profile proliferative quiescent...