A5018108251- Viral Infections and Vectors
- Chromosomal and Genetic Variations
- Studies on Chitinases and Chitosanases
- Antibiotic Resistance in Bacteria
- Genetic Associations and Epidemiology
- Mosquito-borne diseases and control
- Insect Resistance and Genetics
- Epigenetics and DNA Methylation
- HIV Research and Treatment
- Nutrition, Genetics, and Disease
- Ethnobotanical and Medicinal Plants Studies
- Hepatitis B Virus Studies
- Plant Pathogenic Bacteria Studies
- Antibiotics Pharmacokinetics and Efficacy
- African Botany and Ecology Studies
- Paraoxonase enzyme and polymorphisms
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- RNA modifications and cancer
- Pharmacological Effects of Medicinal Plants
- Burkholderia infections and melioidosis
- Cancer-related molecular mechanisms research
- Apelin-related biomedical research
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
Taibah University
2020-2025
Riyadh Armed Forces Hospital
2022
Prince Mohammed bin Abdulaziz Hospital
2022
Jordan University of Science and Technology
2022
Ministero della Salute
2022
University of Bristol
2013-2017
Taif University
2013
Sher-i-Kashmir Institute of Medical Sciences
2010
The four serotypes of dengue virus (DENV-1 to -4) cause the most important arthropod-borne viral disease humans. DENV non-structural protein 5 (NS5) contains enzymatic activities required for capping and replication RNA genome that occurs in host cytoplasm. However, previous studies have shown DENV-2 NS5 accumulates nucleus during infection. In this study, we examined nuclear localization all serotypes. We demonstrate first time there are serotypic differences localization. Whereas -3...
The development of live viral vaccines relies on empirically derived phenotypic criteria, especially small plaque sizes, to indicate attenuation. However, while some candidate successfully translated into licensed applications, others have failed safety trials, placing vaccine a hit-or-miss trajectory. We examined the determinants phenotype in two dengue virus (DENV) candidates, DENV-3 PGMK30FRhL3, which produced acute febrile illness recipients, and DENV-2 PDK53, has good clinical profile....
Aedes aegypti is a vector for the (re-)emerging human pathogens dengue, chikungunya, yellow fever and Zika viruses. Almost half of Ae. genome comprised transposable elements (TEs). Transposons have been linked to diverse cellular processes, including establishment viral persistence in insects, an essential step transmission vector-borne However, up until now it has not possible study overall proteome derived from organism's mobile genetic elements, partly due highly divergent nature TEs....
DNA repair mechanisms, particularly RAD51-mediated homologous recombination repair, play a crucial role in breast cancer development, with the rs1801320 (135G > C) polymorphism showing conflicting associations across studies. This meta-analysis aimed to assess relationship between RAD51 and susceptibility. We systematically searched PubMed Web of Science databases through August 15, 2024, included 16 case–control studies comprising 4743 cases 4448 controls, analyzing various genetic models...
Brucellosis is a highly contagious, neglected zoonotic disease of major importance worldwide. The endemic in many countries, burdening healthcare systems and the livestock industry representing persistent public health concern these countries. considered an important occupational hazard for workers. Limited studies have investigated human brucellosis Saudi Arabia. Therefore, this study aimed to estimate prevalence among employees high-risk professions, including veterinarians, animal...
Introduction This study aimed to evaluate the prevalence of Klebsiella pneumoniae contamination in raw lettuce from Risalpur, Pakistan, and analyze antibiotic susceptibility profiles isolated strains. The presence foodborne pathogens such as K. poses significant public health risks, particularly regions with suboptimal hygiene practices improper food handling. Methods Lettuce samples were collected various sources Risalpur screened for . Antimicrobial testing was performed effectiveness...
This study aimed to highlight the importance of mutations within Proteus mirabilis genome that are related fluoroquinolone resistance.This is a cross sectional performed in different teaching hospitals Khartoum State from June 2016 May 2017. A total (120) P isolates patients with symptoms UTIs attending were examined. First, modified Kurby Bauer method was for phenotypical detection resistant isolates. Then polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
To study the genotype and allele frequency of fat mass obesity-associated (FTO) rs8050136 A>C genetic variant investigate its association with type 2 diabetes mekkitus (T2DM) parameters.This was carried out on 118 diabetic patients 106 healthy individuals (control) from Prince Mohammed bin Abdulaziz Hospital, Al Madinah Munawarah, Saudi Arabia. The TaqMan single-nucleotide polymorphism (SNP)genotyping assay used for genotyping.The AA same among T2DM control groups (21%). However, CC 19.5% in...
The interaction of T cells with infected macrophages depends on the interplay cytokines produced in each cell, and this mechanism is a key to protective immunity against Mycobacterium tuberculosis. Extensive research has been devoted studying changes systemic cytokine levels patients tuberculosis (TB), but results are inconclusive. Determine Th1 Th2 immune response among new TB compared follow-up healthy control.Cross-sectional laboratory-based study.Immunology Laboratory, National Center...
Lassa fever, commonly known as hemorrhagic fever (LHF), is one of the progressive illnesses invading a large population two to three million individuals in West Africa. The infection transmitted through rodents severely impacts local and medical professionals surrounding areas, which were also primary target LHF. In epidemic causes public health threat since it poses significant morbidity fatality Case rate (CFR) ≥ 50%). disease widespread Africa has developed into most common...
There is a growing interest in medicinal plants recent years due to their many therapeutic benefits and low side effects. Among the African Adansonia digitata (baobab) that has edible fruit. In current study, effect of A. juice consumption on lipid profile was investigated. addition, inhibition oxidation low-density lipoprotein cholesterol (LDL-C) in-vitro by essential oil (EO) also investigated.In this cohort total 70 subjects users (AD group, 42 male 28 female) non (Non-AD 44 26 were...
Type 2 diabetes mellitus (T2DM) is a challenge to global health.About 400 million people are affected globally, and this figure expected skyrocket steeply in the coming decades.T2DM patients at risk of developing serious life-threatening problems, necessitating increased medical attention, detecting undiagnosed preventing it particularly important.T2DM's etiology molecular causes have yet be fully determined.Its development could influenced by epigenetic alterations.Hence, work, level...