A5074424051- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Neurobiology and Insect Physiology Research
- Physiological and biochemical adaptations
- Invertebrate Immune Response Mechanisms
- Photoreceptor and optogenetics research
- Single-cell and spatial transcriptomics
- Birth, Development, and Health
- Rabbits: Nutrition, Reproduction, Health
- thermodynamics and calorimetric analyses
- Inflammasome and immune disorders
- Luminescence and Fluorescent Materials
- RNA modifications and cancer
- Mosquito-borne diseases and control
- Cancer, Lipids, and Metabolism
- Insect symbiosis and bacterial influences
- Neural dynamics and brain function
- Aquaculture disease management and microbiota
- Advanced biosensing and bioanalysis techniques
- Advanced Materials and Mechanics
- Genomics, phytochemicals, and oxidative stress
- Ferroptosis and cancer prognosis
- Molecular Sensors and Ion Detection
- Neuroendocrine regulation and behavior
Doshisha University
2025
RIKEN Center for Brain Science
2020-2024
RIKEN
2022-2024
Pioneer (Japan)
2020-2023
Brandeis University
2015-2021
The University of Tokyo
2008-2014
Japan Science and Technology Agency
2013
Mechanical nonreciprocity, or the asymmetric transmission of mechanical quantities between two points in space, is crucial for developing systems that can guide, damp, and control energy. We report a uniform composite hydrogel displays substantial owing to direction-dependent buckling embedded nanofillers. This material exhibits an elastic modulus more than 60 times higher when sheared one direction compared with opposite direction. Consequently, it transform symmetric vibrations into ones...
We identified a rhodol bearing hydroxymethyl group (HMDER) as suitable scaffold for designing fluorescence probes various hydrolases. HMDER shows strong at physiological pH, but phenolic O-alkylation of results in preference the spirocyclic form, which has weak fluorescence. As proof concept, we utilized this finding to develop new probe β-galactosidase. This favorable characteristics imaging biological samples: it good cellular permeability, and its hydrolysis product is well-retained...
Sterile inflammation triggered by endogenous factors is thought to contribute the pathogenesis of acute and chronic inflammatory diseases. Here, we demonstrate that apoptosis-deficient mutants spontaneously develop a necrosis-driven systemic immune response in Drosophila provide an vivo model for studying organismal sterile inflammation. Metabolomic analysis hemolymph from revealed increased sarcosine reduced S-adenosyl-methionine (SAM) levels due glycine N-methyltransferase (Gnmt)...
Internal state alters sensory behaviors to optimize survival strategies. The neuronal mechanisms underlying hunger-dependent behavioral plasticity are not fully characterized. Here we show that feeding C. elegans thermotaxis behavior by engaging a modulatory circuit whose activity gates the output of core network. Feeding does alter comprised AFD thermosensory and AIY interneurons. Instead, prolonged food deprivation potentiates temperature responses in AWC neurons, which inhibit...
Enzymatically formed side-chain oxysterols function as signaling molecules regulating cholesterol homeostasis and act intermediates in the biosynthesis of bile acids. In addition to these physiological functions, an imbalance oxysterol has been implicated pathophysiology. Cholesterol 25-hydroxylase (CH25H) its product 25-hydroxycholesterol (25-OHC), also by autoxidation, are associated with amyotrophic lateral sclerosis. However, effects 25-OHC on cell viability glial cells remain unclear....
Information about nutrient availability is assessed via largely unknown mechanisms to drive developmental decisions, including the choice of Caenorhabditis elegans larvae enter into reproductive cycle or dauer stage. In this study, we show that CMK-1 CaMKI regulates decision as a function feeding state. acts cell-autonomously in ASI, and non AWC, sensory neurons regulate expression growth promoting daf-7 TGF-β daf-28 insulin-like peptide (ILP) genes, respectively. Feeding state dynamic...
Effective defense responses involve the entire organism. To maintain body homeostasis after tissue damage, a systemic wound response is induced in which of each tightly orchestrated to avoid incomplete recovery or an excessive, damaging response. Here, we provide evidence that wounding, apoptotic caspase pathway activated downstream reactive oxygen species midgut enterocytes (ECs), cells distant from site, Drosophila. We show caspase-pathway mutant has defects homeostatic gut cell renewal...
Degenerate networks can drive similar circuit outputs. Via acute manipulation of individual neurons, we previously identified components that are necessary and sufficient to starvation-dependent plasticity in C. elegans thermotaxis behavior. Here find when these instead silenced chronically, degenerate mechanisms compensate this Our results indicate degeneracy neuronal network function be revealed under specific experimental conditions.
The mechanisms by which the innate immune system senses damage have been extensively explored in multicellular organisms. In Drosophila, various types of tissue damage, including epidermal injury, tumor formation, cell competition, and apoptosis deficiency, induce sterile activation Toll pathway, a process that requires use extracellular serine protease (SP) cascades. Upon infection, SP Spätzle (Spz)-processing enzyme (SPE) cleaves activates ligand Spz downstream two paralogous SPs, Hayan...
<title>Abstract</title> Recent studies employing live-cell transcriptomics have demonstrated measurement of the temporal changes in gene expression single cells cultured vitro. However, time-series analyses and vivo applications remain unexplored. Here, we show that nanoelectrokinetic sampling uniquely enables organism at multiple time points to uncover individuality dynamic organisms. Autoregression with a transcriptome offers an inference single-cell regulation networks, which provide...
Abstract Internal state alters sensory behaviors to optimize survival strategies. The neuronal mechanisms underlying hunger-dependent behavioral plasticity are not fully characterized. Here we show that feeding regulates C. elegans negative thermotaxis behavior by engaging a modulatory circuit whose activity gates the output of core network. Feeding does alter comprised AFD thermosensory and AIY interneurons. Instead, prolonged food deprivation potentiates temperature responses in AWC...
Senses are key to responding environmental stimuli and survival depends on appropriate responses. Although researchers have identified the cells molecules essential sensing each stimuli, it remains relatively unknown how pathways interact when animals receive multiple stimuli. Asuka Takeishi, Laboratory for Neural Circuit of Multisensory Integration, Japan, is working identify mechanism sensory integration by exposing Caenorhabditis elegans (C. elegans) odour temperature The goal this...
Behavioral plasticity is one of the most important strategies by which animals can adapt to transient environmental changes for their survival. Biological systems must be flexible enough induce and maintain behavioral plasticity while still being finely regulated, especially in response life-threatening situations like starvation. Animals produce behavior stimuli, altered when starvation paired with a range stimuli (associative learning). Such mechanisms associative learning have...