A5053771912- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Viral gastroenteritis research and epidemiology
- Amino Acid Enzymes and Metabolism
- Mitochondrial Function and Pathology
- Bacterial biofilms and quorum sensing
- Liver Diseases and Immunity
- Hemoglobinopathies and Related Disorders
- Metabolism and Genetic Disorders
- RNA regulation and disease
- Retinal Development and Disorders
- Thyroid Disorders and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Protease and Inhibitor Mechanisms
- Protein purification and stability
- Genetics and Neurodevelopmental Disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Bone and Joint Diseases
- Nuclear Structure and Function
- Gout, Hyperuricemia, Uric Acid
Intas Pharmaceuticals (India)
2025
Bangladesh University of Health Sciences
2016-2023
Bangladesh Institute of Development Studies
2019-2023
National Institute of Neurological Disorders and Stroke
2023
University of Dhaka
2020-2023
National Institutes of Health
2023
Development Initiatives
2022
Genomics England
2020
University of Health Sciences Antigua
2014
Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders
2014
PurposeDetermining the role of DYNC2H1 variants in nonsyndromic inherited retinal disease (IRD).MethodsGenome and exome sequencing were performed for five unrelated cases IRD with no identified variant. In vitro assays developed to validate (fibroblast assay, induced pluripotent stem cell [iPSC] derived organoids, a dynein motility assay).ResultsFour novel (V1, g.103327020_103327021dup; V2, g.103055779A>T; V3, g.103112272C>G; V4, g.103070104A>C) one previously reported variant (V5,...
Lamins are the major component of nuclear lamina, maintaining structural integrity nucleus. Lamin A/C variants well established to cause a spectrum disorders ranging from myopathies progeria, termed laminopathies. Phenotypes resulting in LMNB1 and LMNB2 have been much less clearly defined.
Background: The phenomenon of breakthrough infection during the COVID-19 pandemic has raised concerns regarding efficacy vaccinations and healthcare providers are exposed to instances on a regular basis for professional reasons, putting them at risk. This study was aimed look into SARS-CoV-2 IgG status among providers, reported with infections. Methods: involved 78 (e.g., doctors, nurses, Lab personnel, support staffs) from tertiary care hospital in Dhaka city. Blood samples were collected...
Liquid Chromatography tandem mass spectrometry (LC-MS/MS) is used for the diagnosis of more than 30 inborn errors metabolisms (IEMs). Accurate and reliable IEMs by quantifying amino acids (AAs) acylcarnitines (ACs) using LC-MS/MS systems depend on establishment age-specific cut-offs analytes. This study aimed to (1) determine cut-off values AAs ACs in Bangladesh (2) validate method patients with IEMs. A total 570 enrolled healthy participants were divided into 3 age groups, namely, newborns...
The study investigated the spectrum of antibiotic resistance and associated genes for aminoglycoside, macrolide ESBL class antibiotics using clinical isolates. A total 430 preserved bacterial strains (Acinetobacter baumannii, n= 20; Pseudomonas aeruginosa, 26; Klebsiella pneumoniae, 42; E. coli , 85; Staphylococcus aureus, 84; Salmonella Typhi, 82; Enterococcus spp., 27; Streptococcus 36 CNS, n = 28) were examined. isolated from patients admitted to various tertiary hospitals Dhaka city...
Abstract Objectives Characterisation of resistance phenotype and genotype is crucial to understanding the burden transmission antimicrobial (AMR). This study aims determine spectrum AMR associated genes encoding aminoglycoside, macrolide β‐lactam classes antimicrobials in bacteria isolated from hospitalised patients Bangladesh. Methods 430 bacterial isolates with respiratory, intestinal, wound infections typhoid fever, presenting clinical care 2015 2019, were examined. They included...
Although thyroid dyshormonogenesis (TDH) accounts for 10-20% of congenital hypothyroidism (CH), the molecular etiology TDH is unknown in Bangladesh. Thyroid peroxidase (TPO) most frequently associated with and present study investigated spectrum TPO mutations Bangladeshi patients analyzed effects on protein structure through silico approach. Sequencing-based analysis gene revealed four 36 diagnosed including three nonsynonymous mutations, namely, p.Ala373Ser, p.Ser398Thr, p.Thr725Pro, one...
The use of silver is rapidly rising in wound care and silver-containing dressings are widely used along with other antibiotics, particularly β-lactams. Consequently, concerns being raised regarding the emergence silver-resistance cross-resistance to Therefore, this study aimed determine phenotypic genotypic profiles extended-spectrum β-lactamases isolates from chronic wounds.317 swab specimens were collected tertiary hospitals Dhaka city analysed for microbial identification. antibiotic...
Transfusion transmitted infections have remained a major deterrent to public health, particularly among the patients with transfusion-dependent Beta thalassemia in developing countries. Although proper donor selection through adoption of WHO-advised infection panel has lowered rate infections, multi-transfused are not free risk. In this study, we screened 148 determine frequency Hepatitis C Virus (HCV), B (HBV) and Human Immunodeficiency (HIV) using ELISA method. Among them, infected cases...
Serological analysis is an integral part of laboratory practice nowadays. The present study was aimed to develop and validate a modified Enzyme linked Immunosorbent Assay (ELISA) for determination IgG antibody against Hepatitis E Virus (HEV) using dried blood spots (DBS) corresponding plasma samples. A total 65 samples (45 HEV patients, 20 healthy controls) were analyzed. DBS demonstrated equivalent optical densities detecting anti-HEV IgG. highly significant correlation observed between...
ObjectivesTo determine IgG immune responses and hepatitis E virus (HEV) viral load, to explore the associations with pregnancy.MethodsA total of 121 HEV-infected women (57 pregnant, 64 non-pregnant) were analysed. Quantitative reverse transcription PCR (RT-qPCR) was done for 78 HEV IgM-positive patients Sanger sequencing performed 62 HEV-RNA-positive confirm genotyping. ELISA conducted antibody avidity indices.ResultsThe genotype identified as variant 1. Significant negative correlations...
An attempt was made to see the seropositivity and pattern of four common hepatotrophic viruses (HBV, HCV, HEV, HAV) in patients suspected have been suffering from viral hepatitis. Blood samples 2,995 cases HBV infection, 331 155 HEV 24 HAV were tested for these markers. Of a total 245 (8.1%) positive HBsAg, 18 (5.4%) 87 (56.1%) 8 (33.3%) infection. The predominant age group affected is 25-40 years, HCV > 61 26-50 years under 11 years. Seropositivity HBsAg statistically higher (near double)...
Background: Hepatitis B (HBV) and hepatitis C virus (HCV) infection is common among patients on maintenance hemodialysis (MHD). This study was undertaken to observe prevalence of in patients, their family members dialysis staffs.Methods: In this cross-sectional 3 groups were included as gr-1 MHD, the first-degree relatives gr-2 staffs gr-3. Clinical laboratory investigations done. Viral serology surface antigen (HBsAg) antibody against (anti-HCV) done by enzyme linked immunosorbent sorbent...
Background: CKD patients are associated with HBV infection both as a cause and complication of treatment. before starting dialysis therapy considered high risk group because impaired immune response compared healthy individuals also other factors related treatment management. Only HBsAg marker does not always follow the presence or absence infection. Anti-HBc (total) alone positivity indicates previous exposure to infection, window period even after reactivation resolved In some cases only...
Prostate specific antigen (PSA) is an important tool for the diagnosis, prognosis and follow up of prostatic cancer, most common malignancy male throughout world. It safe, reliable, specific, noninvasive test if done properly. However there are many benign, inflammatory other conditions which can also give rise to elevated PSA value thus limits its use. Different methods estimation may variable level. More over normal reference range be depending on age, geographic situation, environmental...
Background: Hepatitis caused by hepatitis E Virus (HEV) is not uncommon in developing countries. It usually a self-limiting conferring immunity against subsequent infection. However, HEV infection during pregnancy results varying degree of morbidity, often fatal. The present study was designed to find out the seroprevalence subclinical at different trimesters without history hepatitis.Materials and Methods: A total 255 asymptomatic healthy pregnant women three (85×3=255) with no jaundice...
This case control study was undertaken to see if there is any association of serum Zinc level with histologically diagnosed prostatic cancer patients. Also re-establish the importance estimation Prostate specific antigen PSA, (Total, Free and ratio between free total) in prostate It evident from present that has got statistically significant difference patients (p<0.000),. Total PSA total also significantly different (p<0.04 0.006 respectively). However no observed this two groups...
Abstract Transfusion transmitted infections (TTIs) have remained a major deterrent to public health, particularly among the patients with transfusion-dependent Beta thalassemia in developing countries. Although proper donor selection through adoption of WHO-advised infection panel has lowered rate infections, multi-transfused are not free risk. The present study screened 148 determine frequency HCV, HBV and HIV using ELISA method. Among these patients, infected cases were 13.51%, 3.37% 0%,...
Background: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily effects elderly population and commonly involves pain in the joints (the wrist hands). Gout form of caused by excess uric acid blood stream, which can affect several joints. The co-occurrence RA gout same patient rarely reported. aim this study was to assess level serum among patients with RA, observe any associations levels RA.Methods: In descriptive cross-sectional study, total 70 samples were collected...
Abstract not available DOI: http://dx.doi.org/10.3329/jemc.v4i3.20939 J Enam Med Col 2014; 4(3): 138-140