A5064412665- Tuberculosis Research and Epidemiology
- COVID-19 and Mental Health
- Healthcare professionals’ stress and burnout
- SARS-CoV-2 detection and testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Posttraumatic Stress Disorder Research
- Public Health Policies and Education
- Mycobacterium research and diagnosis
- COVID-19 epidemiological studies
- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Diagnosis and treatment of tuberculosis
- Diabetes Management and Research
- Pharmaceutical industry and healthcare
- Food Security and Health in Diverse Populations
- Infection Control and Ventilation
- HIV Research and Treatment
- Diabetes Treatment and Management
- Urinary Tract Infections Management
- Health Systems, Economic Evaluations, Quality of Life
- Disaster Response and Management
- Pharmaceutical Economics and Policy
- Palliative Care and End-of-Life Issues
- COVID-19 and healthcare impacts
- Healthcare and Environmental Waste Management
Centers for Disease Control and Prevention
2022-2024
National Center for Emerging and Zoonotic Infectious Diseases
2023-2024
Office of Tribal Affairs and Strategic Alliances
2023
Oak Ridge Associated Universities
2022
National Institutes of Health
2022
The Centers
2022
E Ink (South Korea)
2022
Government of the United States of America
2022
Computer Emergency Response Team
2022
Humana (United States)
2019-2021
Objective: Tumor necrosis factor (TNF), an important inflammatory mediator in tuberculosis, has been implicated causing accelerated HIV disease progression HIV-associated tuberculosis. However, TNF blockade, particularly by monoclonal antibody, associated with the reactivation of latent Mycobacterium tuberculosis infection impairment mycobacterial immunity. This phase 1 study examined safety, microbiology, immunology, and virology blockade using etanercept (soluble receptor, Enbrel) during...
ABSTRACT We examined sputum bacterial loads in adults with newly diagnosed tuberculosis using quantitative culture and time-until-positive (DTP) BACTEC 460. Patients cavitary disease had higher CFU levels than those without cavities shorter DTPs. Within radiographic strata of moderately far advanced tuberculosis, counts were associated disease.
Rationale: Cavitary disease and delayed culture conversion have been associated with relapse. Combining patient characteristics measures of bacteriologic response might allow treatment shortening current drugs in some patients.Objectives: To assess whether could be shortened from 6 to 4 months patients noncavitary tuberculosis whose sputum cultures converted negative after 2 months.Methods: This study was a randomized, open-label equivalence trial. HIV-uninfected adults were treated daily...
mRNA is a marker of cell viability. Quantifying Mycobacterium tuberculosis in sputum promising tool for monitoring response to antituberculosis therapy and evaluating the efficacy individual drugs. levels were measured specimens from patients with (TB) receiving monotherapy an early bactericidal activity study fluoroquinolones those standard rifampin-based regimen interleukin-2 (IL-2) trial. In study, quantitative culture analysis was collected 2 days before daily during 7 drug...
During November 19-21, 2021, an indoor convention (event) in New York City (NYC), was attended by approximately 53,000 persons from 52 U.S. jurisdictions and 30 foreign countries. In-person registration for the event began on 18, 2021. The venue equipped with high efficiency particulate air (HEPA) filtration, attendees were required to wear a mask indoors have documented receipt of at least 1 dose COVID-19 vaccine.* On December 2, Minnesota Department Health reported first case...
Abstract Background Infectious diseases (ID) physicians play a crucial role in public health emergencies. Effective collaboration between agencies and healthcare providers is essential for coordinated response. However, there limited information on how ID departments collaborate which areas need to be improved. Here, we identify ways enhance preparedness through increased state, tribal, local, territorial departments. Methods We performed secondary qualitative analysis of 37 telephone...
Objectives: To examine metabolic monitoring rates in commercially insured children and adolescents treated with a second-generation antipsychotic (SGA) during calendar years (CYs) 2016 2017. Methods: In this retrospective study, data were collected from large national commercial health plan for the period covering January 1, to December 31, Commercially adolescents, aged 8-19 ≥2 SGA prescription claims CY, identified CY2016 CY2017 cohorts. The primary outcome of interest was percentage...
Aims Approximately 50% of patients with heart failure have preserved (≥50%) ejection fraction (HFpEF). Improved understanding the phenotypic heterogeneity HFpEF might facilitate development targeted therapies and interventions. Methods This retrospective study characterized a cohort based on similar clinical profiles evaluated 1-year related hospitalization. Enrolment, medical pharmacy data were used to identify newly diagnosed enrolled in Medicare Advantage Prescription Drug or commercial...
Objectives: Early in the COVID-19 pandemic, several outbreaks were linked with facilities employing essential workers, such as long-term care and meat poultry processing facilities. However, timely national data on which workplace settings experiencing unavailable through routine surveillance systems. We estimated number of US identified types they occurred during August–October 2021. Methods: The Centers for Disease Control Prevention collected from health departments August October 2021:...
To evaluate the association between risk factors, mitigating and adverse mental health outcomes among United States public workers.Cross-sectional online survey data were collected March to April 2021. The was distributed workers who worked in a state, tribal, local, or territorial department since 2020.In total, 26,174 state local completed survey. Feeling isolated factor for anxiety (PR, 1.84; 95% CI, 1.74-1.95), depression 1.75-1.94), post-traumatic stress disorder 1.50; 1.43-1.57),...
A lack of timely and high-quality data is an ongoing challenge for public health responses to COVID-19 among people experiencing homelessness (PEH). Little known about the total number cases PEH.To estimate PEH compare incidence rate with that in general population.This cross-sectional study used from a survey distributed by Centers Disease Control Prevention all US state, district, territorial departments requested aggregated January 1, 2020, September 30, 2021. Jurisdictions were...
Despite high rates of reported mental health symptoms among public workers (PHWs) during the COVID-19 pandemic, utilization employer-offered resources was low. Our objective to understand what barriers and deterrents exist for PHWs accessing resources.Four national organizations disseminated a online survey department employees March-April 2021; 26 174 completed survey. We examined 5164 write-in responses using thematic analysis identify key reasons why were not time off employee assistance...
During the COVID-19 pandemic, unemployment rate in United States peaked at 14.8% April 2020. We examined patterns following this peak counties with rapid increases incidence.We used CDC aggregate county data to identify incidence (rapid riser counties) during July 1-October 31, a linear regression model fixed effect calculate change of difference these counties, stratified by county's social vulnerability (an indicator compiled CDC) two months before index month compared plus one after...
ABSTRACT Tuberculosis (TB) is the most common life-threatening infection in human immunodeficiency virus (HIV)-infected persons and frequently occurs before onset of severe immunodeficiency. Development TB associated with increased HIV type 1 (HIV-1) viral load, a fall CD4 lymphocyte counts, mortality. The aim this study was to examine how treatment pulmonary affected HIV-1 activity HIV-1/TB-coinfected subjects cell counts >100 cells/μl. were recruited Kampala, Uganda, monitored over...
During clinical trials, mirabegron, a β3-adrenoreceptor agonist, was associated with increased vital signs vs placebo in patients overactive bladder.The purpose of this study to compare incidence rates adverse cardiovascular (CV) outcomes following mirabegron or antimuscarinic use.We conducted an observational post-marketing safety utilising real-world data. The population identified within five sources: Danish and Swedish National Registers, Clinical Practice Research Datalink (UK), Optum...
In this case study, we aim to understand how health departments in 5 US jurisdictions addressed inequities and implemented strategies reach populations disproportionately affected by COVID-19 during the initial Omicron variant period. We used qualitative methods examine department experiences surge, from November 2021 April 2022, assessing successful interventions, barriers, lessons learned efforts promote equity. Our findings indicate that government leadership supported prioritizing equity...
<title>Abstract</title> Background The U.S. Centers for Disease Control and Prevention (CDC) initiated the National Wastewater Surveillance System (NWSS) in September 2020. Four of Excellence (COEs) were established between 2021–2023 Houston (Texas), Colorado, Wisconsin, California to guide wastewater surveillance efforts public health. Our objective was increase understanding factors that facilitated implementation from perspectives experiences shared by health department COEs utility...
An increase in adverse mental health symptoms occurred the general population at onset of COVID-19 pandemic, which peaked 2020 and subsequently decreased (1-3). The pandemic exacerbated existing stress fatigue among public workers responding to crisis.* During March-April 2021, a survey state, tribal, local, territorial (STLT) found that 52.8% respondents experienced least one following conditions: depression, anxiety, or posttraumatic disorder (PTSD) (4); however, more recent estimates this...
This post-authorization safety study (EU PAS Register Number: EUPAS16088) was designed to compare the incidence of cancer outcomes in patients treated with mirabegron versus antimuscarinic medications.Cohorts initiators during 2012-2018 were propensity-score matched medication within real-world data sources (Danish National Registers, Swedish Clinical Practice Research Datalink [UK], Optum [US], and Humana [US]). Incident cases identified follow-up from direct linkage registers or validated...
Health departments (HDs) work on the front lines to ensure health of their communities, providing a unique perspective public response activities. Say Yes! COVID Test (SYCT) is US federally funded program free COVID-19 self-tests communities with high transmission, low vaccination rates, and social vulnerability. The collaboration 9 HDs was key for distribution 5.8 million between March 31 November 30, 2021.
Liraglutide and sitagliptin were compared on glycemic control all-cause healthcare costs over a 1-year period among older adults with type 2 diabetes (65–89 years) enrolled in national Medicare Advantage Prescription Drug health plan. This was retrospective study which the index date first prescription fill for liraglutide or between 25 January 2010 31 December 2014. Post-index treatment persistence glycosylated hemoglobin (HbA1c) at baseline 1 year (± 90 days) post-index required. Patients...
To evaluate healthcare provider awareness and uptake of the Centers for Medicare & Medicaid Services (CMS) billing coronavirus disease 2019 (COVID-19) prevention counselling delivery to patients awaiting severe acute respiratory syndrome 2 test results.Cross sectional survey US-based providers in February 2021.Analysis associations with provider-reported CMS guidance type, specialty, work setting.A total 1919 responded survey. Overall, 38% (726/1919) reported available reimbursement COVID-19...
The risk for mpox virus (MPXV) transmission in most workplaces has not been thoroughly assessed the context of 2022 global outbreak. Our objectives were to describe case patients who worked while infectious and subsequent workplace contact tracing efforts, assessments, outcomes.