A5002297697- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Pregnancy and preeclampsia studies
- Viral Infectious Diseases and Gene Expression in Insects
- T-cell and Retrovirus Studies
- Acute Lymphoblastic Leukemia research
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
- Mesenchymal stem cell research
- Osteomyelitis and Bone Disorders Research
- Epigenetics and DNA Methylation
- Orthopedic Infections and Treatments
- Ubiquitin and proteasome pathways
- Phagocytosis and Immune Regulation
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Organ Transplantation Techniques and Outcomes
- Salivary Gland Disorders and Functions
- Transplantation: Methods and Outcomes
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
Institut Necker Enfants Malades
1997-2020
Inserm
1991-2017
Centre National de la Recherche Scientifique
2016-2017
Université Paris Cité
1982-2017
Délégation Paris 5
2016-2017
Sorbonne Paris Cité
2016
Sorbonne Université
1982-2007
Institut Pasteur
2003-2004
Harvard University
2003
Hôpital Necker-Enfants Malades
2000
In the absence of thymopoiesis, T lymphocytes are nevertheless present, mainly in gut epithelium. Ontogeny extrathymic pathway and extent its involvement euthymic mice controversial. These questions have been addressed by assessing expression recombinase activating gene (RAG) through use green fluorescent protein RAG2 transgenic mouse models. athymic mice, lymphopoiesis occurs mesenteric lymph node less Peyer's patches. Ontogenic steps this resemble those but with an apparent bias toward γδ...
Gut intraepithelial CD8 T lymphocytes (T-IEL) are distinct from thymus-derived cells and thought to derive locally cryptopatch (CP) precursors. The intermediate stages of differentiation between CP mature T-IEL were not identified, the local process was characterized. We identified characterized six phenotypically lineage-negative populations in gut epithelium: (a) we determined kinetics their generation bone marrow precursors; (b) quantified CD3-ϵ, recombination activating gene (Rag)-1,...
Abstract Natural regulatory T cells (Tregs) are present in high frequencies among tumor-infiltrating lymphocytes and draining lymph nodes, supposedly facilitating tumor development. To investigate their role controlling local immune responses, we analyzed intratumoral cell accumulation function the presence or absence of Tregs. Tumors that grew normal BALB/c mice injected with 4T1 line were highly infiltrated by Tregs, CD4 CD8 cells, all having unique characteristics. Most infiltrating Tregs...
Bone marrow transplantation (BMT) is currently used to treat patients with severe aplastic anemia or leukemia. Despite the use of an HLA identical sibling donor, however, survival after BMT reduced by occurrence two major immunologic complications: graft-vs-host disease and a long-lasting immune deficiency responsible for late infections. This could be explained imbalance lymphocyte subpopulations reconstituted transplant. The aim present work was study helper function measuring production...
A common feature of T cell acute lymphoblastic leukemias (T-ALLs) is the presence structural alteration 5' part tal-1 locus, localized on chromosomal band 1p32. These alterations consist either a t(1;14)(p32;q11) translocation (3% T-ALLs) or tald submicroscopic deletion (12-25% additional T-ALLs). We have characterized case T-ALL with in which, unlike majority t(1;14), recombination receptor delta elements affected 3' side locus. In this case, transcription initiated from promoter located...
Cytomegalovirus (CMV) viremia was systematically studied in 56 patients having undergone bone marrow transplantation for leukemia or aplastic anemia. Of the who survived at least three months, 57% had CMV with a frequency peak between 7th and 9th weeks. We describe possible clinical signs associated viremia, particularly late peripheral and/or central thrombocytopenia. The occurrence of according to specific preexisting immune status recipients donors; granulocyte transfusions...
Natural regulatory T (Treg) cells interfere with multiple functions, which are crucial for the development of strong anti-tumour responses. In a model 4T1 mammary carcinoma, depletion CD25+Tregs results in tumour regression Balb/c mice, but mechanisms underlying this process not fully understood. Here, we show that partial Treg leads to generation particular effector CD8 cell subset expressing CD11c and low level PD-1 draining lymph nodes. These have capacity migrate into tumour, kill DCs,...
Pre- and post-transplant sera from 51 cases of bone marrow transplants performed for severe aplastic anemia were tested on monocytes (M) corresponding B cells (B) a panel unrelated donors. One-third the cytotoxic M either different or same individuals, while 45% reacted only to appeared recognize non-HLA M-associated antigens. No significant reaction endothelial was obtained with these sera. The subsequent clinical course not associated any pattern pre-transplant There relationship between...
The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion mutual redundancy and therefore this concept still matter debate. Our data show cyclin D1 indispensable for normal hematopoiesis. Indeed, absence D1, either genetic deficient mice, or after acute ablation by RNA interference, D2 D3 also not expressed preventing hematopoietic division...
Thirty-seven patients with chronic granulocytic leukemia have been treated supralethal chemoradiotherapy followed by transplantation of bone marrow from HLA-identical donors. All showed engraftment, and the Philadelphia chromosome (PH1) disappeared in each case. Four had syngeneic grafts before blast crisis are still alive; 2 remission not maintained therapy, others receiving chemotherapy after having relapsed phase. Thirty-three allogeneic grafts; only received during crisis, neither is a...
Azogui, O.; Kalil, J.; Andersen, E.; Guillet, Fellous, M.; Gluckman, E. Author Information