A5022421400- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
Inserm
2017-2021
École Normale Supérieure de Lyon
2017-2021
Université Claude Bernard Lyon 1
2017-2021
Centre National de la Recherche Scientifique
2017-2021
Fondation pour la Recherche Médicale
2021
Centre International de Recherche en Infectiologie
2017-2019
La Ligue Contre le Cancer
2017
Human T lymphotropic Virus type 1 (HTLV-1) is the etiological agent of Adult cell Leukemia/Lymphoma (ATLL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Both CD4+ T-cells dendritic cells (DCs) infected with HTLV-1 are found in peripheral blood from carriers. We previously demonstrated that monocyte-derived IL-4 DCs more susceptible to infection than autologous primary T-cells, suggesting DC precedes T-cell infection. However, during transmission, breast-feeding or...
Human T Lymphotropic virus (HTLV) infection can persist in individuals resulting, at least part, from viral escape of the innate immunity, including inhibition type I interferon response infected T-cells. Plasmacytoid dendritic cells (pDCs) are known to bypass by their robust production. Here, we demonstrated that pDCs produce interferons upon physical cell contact with HTLV-infected cells, yet pDC activation inversely correlates ability HTLV-producing transmit infection. We show sense...
The Human T-cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a devastating neurodegenerative disease with no effective treatment, which affects an increasing number of people in Brazil. Immune cells from the adaptive compartment are involved manifestation but whether innate cell functions participate occurrence has not been evaluated. In this study, we analyzed responses at steady state and after blood stimulation using agonist toll-like receptor...
Abstract The Human T-cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a devastating neurodegenerative disease with no effective treatment, which affects an increasing number of people in Brazil. A biological blood factor allowing the prediction occurrence so far not available. In this study, we analyzed innate immunity responses at steady state and after cell stimulation using agonist toll-like receptor (TLR)7/8-signaling pathway samples from...