A5079312704- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Biomedical Research and Pathophysiology
- Pediatric Hepatobiliary Diseases and Treatments
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Chromosomal and Genetic Variations
- Neonatal Health and Biochemistry
- DNA Repair Mechanisms
Albert Einstein College of Medicine
2017-2023
Significance Eukaryotic genomes harbor a vast number of “selfish” DNA elements, including transposable elements and repetitive sequences. They constitute nearly 50% the human genome need to be silenced maintain integrity genome. Aberrant expression such sequences, possibly due failure silencing mechanisms, is associated with diseases, cancer. Silencing these DNAs involves methylation specific lysine residues in nucleosome core particles that help package into chromatin cell nucleus. Here we...
Eukaryotic DNA replicates asynchronously, with discrete genomic loci replicating during different stages of S phase.
Pu.1 is an ETS family transcription factor (TF) that plays critical roles in erythroid progenitors by promoting proliferation and blocking terminal differentiation. However, the mechanisms controlling expression down-regulation of during early erythropoiesis have not been defined. In this study, we identify actions Runx1 itself at gene Upstream Regulatory Element (URE) as major regulators Burst-Forming Unit erythrocytes (BFUe). During erythropoiesis, levels decline, chromatin accessibility...