A5024010361- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Medical Imaging and Pathology Studies
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Ultrasound in Clinical Applications
- Radiopharmaceutical Chemistry and Applications
- Heart Rate Variability and Autonomic Control
- Neurological and metabolic disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- HIV Research and Treatment
- Parathyroid Disorders and Treatments
- Robotics and Sensor-Based Localization
- Coronary Interventions and Diagnostics
- Spine and Intervertebral Disc Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Radiation Therapy and Dosimetry
- Metallurgy and Material Science
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
Manchester University NHS Foundation Trust
2015-2024
University of Manchester
2010-2024
Oakland University
2023
Institute of Technologists
2021
Manchester University
2015-2017
Weill Cornell Medical College in Qatar
2016
Manchester Academic Health Science Centre
2015
Sunderland Royal Hospital
2015
Bristol-Myers Squibb (Germany)
2011
Manchester Royal Infirmary
2007-2008
Quantitative SPECT-CT is a modality of growing importance with initial developments in post radionuclide therapy dosimetry, and more recent expansion into bone, cardiac brain imaging together the concept theranostics generally. The aim this document to provide guidelines for nuclear medicine departments setting up developing their quantitative service guidance on protocols, harmonisation clinical use cases.These practice were written by members European Association Nuclear Medicine Physics,...
AimsTo examine the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in early diagnosis cardiac implantable electronic device (CIED) generator pocket infection.
The use of maximum standardised uptake value (SUVmax) is commonplace in oncology positron emission tomography (PET). Point spread function (PSF) modelling and time-of-flight (TOF) reconstructions have a significant impact on SUVmax, presenting challenge for centres with defined protocols lesion classification based SUVmax thresholds. This has perhaps led to the slow adoption these reconstructions. work evaluated PSF and/or TOF SUVpeak total glycolysis (TLG) under two different schemes...
The interest in quantitative single photon emission computer tomography (SPECT) shows potential a number of clinical applications and now several vendors are providing software hardware solutions to allow 'SUV-SPECT' mirror metrics used PET imaging. This brief technical report assesses the accuracy activity concentration measurements using new algorithm 'xSPECT' from Siemens Healthcare. SPECT/CT data were acquired uniform cylinder with 5, 10, 15 20 s/projection NEMA image quality phantom 25...
Abstract The Society of Nuclear Medicine and Molecular Imaging (SNMMI), founded in 1954, is an international scientific professional organization with a purpose to promote the science, technology, practical application nuclear medicine. European Association (EANM), 1985, nonprofit medical association facilitate communication among individuals medicine pursuing clinical academic excellence. Members SNMMI EANM are physicians, technologists, scientists who specialize research practice will...
Global iodine-123 metaiodobenzylguanidine (I-MIBG) uptake is predictive of cardiovascular events and mortality in patients with heart failure. Normal variations global regional uptake, however, are not well defined few studies have addressed the functional relevance I-MIBG distribution healthy individuals.We performed scintigraphy cardiac autonomic function testing using standardized methodology 15 individuals (mean age 54.6±5.3 years, male : female 10 5) no evidence previous myocardial...
In myocardial perfusion PET, images are acquired during vasodilator stress, increasing the likelihood of intra-frame motion blurring heart in reconstructed static to assess relative perfusion. This work evaluated a prototype data-driven correction (DDMC) algorithm designed specifically for cardiac PET. A torso phantom, with solid defect, was scanned stationary and being manually pulled to-and-fro axial direction random motion. Non-motion-corrected (NMC) DDMC were reconstructed. Total deficit...
The motion due to respiration is responsible for greatly reducing image quality of whole body positron emission tomography, PET. A simple method produce a respiratory signal enable gating PET listmode data using the Microsoft Kinect, consumer grade 3D scanner, presented. Phantom produced by sinusoidally oscillating phantom being tracked an existing commercially available monitoring system and Kinect based contactless tracking shows that outperforms Varian RPM producing higher resolution...
Aim The aim of this study was to determine whether resolution recovery (RR) iterative reconstruction algorithms can consistently produce diagnostic quality myocardial perfusion SPECT images for the patient population routinely scanned in department. Reduced-count data were compared with full-count without RR according our established protocol. desired outcome would be implement software allow a reduction administered activity routine SPECT. Methods Half-count derived from datasets 53 stress...
Apical thinning is a well-known phenomenon in myocardial perfusion SPECT, often attributed to reduced thickness at the apex of left ventricle. Attenuation correction processing appears exaggerate this effect. Although currently there agreement that apical counts are not diagnostic indicator, opinions differ over cause effect; we sought clarify using results from phantom study.A commercially available anthropomorphic torso was expanded attachments mimicking tissue and bone create three...
Objectives The last decade has seen considerable technological innovations in PET detectors with the availability, among other advances, of time-of-flight (TOF). TOF been shown to increase signal-to-noise ratio (SNR), which should allow for a reduction acquired counts while maintaining image quality. Methods Fifty-eight patients referred routine 18F-flurodeoxyglucose (18F-FDG) oncology studies were included this study. Patients weight below or above 100 kg prescribed 350 400 MBq 18F-FDG,...
PET iterative reconstruction algorithms with resolution modelling (RM) can be used to improve spatial in the images. However, RM has a significant impact on quantification, which raises issues for harmonization across multicentre networks or collaborations. This investigation compared quantification from two modern time-of-flight (TOF) PET/CT systems different manufacturers intention harmonize recovery. Images of National Electrical Manufacturers Association image quality phantom...
Quantitative measurements are increasingly used in cancer staging and therapy monitoring. This work investigates the impact of resolution modeling time-of-flight reconstruction on accuracy variability two types activity concentration (AC) measurements, mean maximum, spheres different sizes contrast. Results compared with conventional OSEM that does not include these additions. Positive bias was seen nearly all maximum AC particularly larger, low contrast no or small amounts post-filtering....
Siemens absolute quantitative reconstruction, xSPECT, is available with manufacturer-defined reconstruction presets to assist optimization. This phantom study evaluates the impact of these on spatial dependence activity concentration recovery (ACR). Single-photon emission computed tomography/computed tomography scans a 5 : 1 and 10 (sphere background) contrast NEMA were performed Intevo 6. Three sphere position configurations, achieved by rotating mount through 0°, 120° 240°, used three...