A5011616025- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Ultrasound in Clinical Applications
- Cardiac Imaging and Diagnostics
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Heart Failure Treatment and Management
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Dendrimers and Hyperbranched Polymers
- Cardiac Valve Diseases and Treatments
- Blood properties and coagulation
- Cardiac Fibrosis and Remodeling
- Non-Invasive Vital Sign Monitoring
- Coronary Interventions and Diagnostics
- Nanoparticle-Based Drug Delivery
- Congenital Heart Disease Studies
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Advanced MRI Techniques and Applications
University of Michigan
2014-2025
Michigan United
2013-2025
Michigan Medicine
2013-2025
A. Alfred Taubman Health Care Center
2020-2024
VA Ann Arbor Healthcare System
2015-2024
Icahn School of Medicine at Mount Sinai
2022-2023
Winona State University
2023
Association Clinique et Thérapeutique Infantile du Val de Marne
2021
Veterans Health Administration
2016-2017
University of Illinois Chicago
2011
<h3>Importance</h3> Acutely ill inpatients with COVID-19 typically receive antithrombotic therapy, although the risks and benefits of this intervention among outpatients have not been established. <h3>Objective</h3> To assess whether anticoagulant or antiplatelet therapy can safely reduce major adverse cardiopulmonary outcomes symptomatic but clinically stable COVID-19. <h3>Design, Setting, Participants</h3> The ACTIV-4B Outpatient Thrombosis Prevention Trial was designed as a...
Aims Determination of left ventricular (LV) volumes and ejection fraction (EF) from two-dimensional echocardiographic (2DE) images is subjective, time-consuming, relatively inaccurate because foreshortened views the use geometric assumptions. Our aims were (1) to validate a new method for rapid, online measurement LV real-time three-dimensional (RT3DE) data using cardiac magnetic resonance (CMR) as reference (2) compare its accuracy reproducibility with standard 2DE measurements.
Accurate intravascular volume assessment is critical in the treatment of patients who receive chronic hemodialysis (HD) therapy. Clinically assessed dry weight a poor surrogate volume; however, ultrasound inferior vena cava (IVC) an effective tool for management. This study sought to determine feasibility using operators with limited experience assess IVC dimensions hand-carried ultrasounds (HCU) outpatient clinical setting. The was 89 consecutive at two clinics before and after HD....
To investigate the uptake of a poly(amidoamine) dendrimer (generation 5 [G5]) nanoparticle covalently conjugated to polyvalent folic acid (FA) as targeting ligand into macrophages, and activity an FA- methotrexate (MTX)-conjugated (G5-FA-MTX) therapeutic for inflammatory disease arthritis.
An elevated level of lipoprotein(a), or Lp(a), in the bloodstream has been causally linked to development atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Steady state levels circulating lipoproteins are modulated by their rate clearance, but identity Lp(a) uptake receptor(s) controversial. We performed a genome-scale CRISPR screen functionally interrogate all potential regulators HuH7 cells. Screen validation was single gene disruption overexpression. Direct...
Generation 5 (G5) poly(amidoamide) (PAMAM) dendrimers are synthetic polymers that have been broadly applied as drug delivery carriers. Methotrexate (MTX), an anti-folate metabolite, has successfully used anti-inflammatory to treat rheumatoid arthritis (RA) in the clinic. In this study, we examine therapeutic efficacy of G5 PAMAM dendrimer methotrexate conjugates (G5-MTX) also folic acid (FA) conjugated G5-MTX (G5-FA-MTX) target inflammation-activated folate receptors overexpressing...
Abstract Antiangiogenic therapies, despite initial encouragement, have demonstrated a limited benefit in ovarian cancer. Laboratory studies suggest antiangiogenic therapy–induced hypoxia can induce tumor “stemness” as resistance to therapy develops and limits the therapeutic benefit. Resistance an induction of stemness may be mediated by proangiogenic tumor-associated macrophages (TAM). As such, TAMs been proposed target. We demonstrate here that express high levels folate receptor-2 (FOLR2)...
The ability of cells to detect and respond nucleotide signals in the local microenvironment is essential for vascular homeostasis. enzyme ectonucleotide tri(di)phosphohydrolase-1 (ENTPD1, also known as CD39) on surface leukocytes endothelial metabolizes locally released, intravascular ATP ADP, thereby eliminating these prothrombotic proinflammatory stimuli. Here, we evaluated contribution CD39 atherogenesis apolipoprotein E–deficient (ApoE-deficient) mouse model atherosclerosis. Compared...
Asthma is a complex disease characterized by airway hyperresponsiveness (AHR) and chronic inflammation. Epidemiologic studies have demonstrated that exposures to environmental factors such as ambient particulate matter (PM), major air pollutant, contribute increased asthma prevalence exacerbations.We investigated pathophysiologic responses Baltimore, Maryland, PM (median diameter, 1.78 mum) in murine model of attempted identify PM-specific genomic/molecular signatures.We exposed ovalbumin...
The mechanistic links between exposure to airborne particulate matter (PM) pollution and the associated increases in cardiovascular morbidity mortality, particularly people with congestive heart failure (CHF), have not been identified. To advance understanding of this issue, genetically engineered mice (CREB(A133)) exhibiting severe dilated cardiomyopathic changes were exposed ambient PM collected Baltimore. CREB(A133) mice, which display aberrant cardiac physiology anatomy reminiscent human...
BACKGROUND: SARS-CoV-2 infections cause COVID-19 and are associated with inflammation, coagulopathy, high incidence of thrombosis. Myeloid cells help coordinate the initial immune response in COVID-19. Although we appreciate that myeloid lie at nexus inflammation thrombosis, mechanisms unite two remain largely unknown. METHODS: In this study, used systems biology approaches including proteomics, transcriptomics, mass cytometry to define circulating proteome cell phenotypes subjects RESULTS:...
Despite the fact that nucleotides and adenosine help regulate vascular tone through purinergic signaling pathways, little is known regarding their contributions to pathobiology of pulmonary arterial hypertension, a condition characterized by elevated resistance remodeling. Even less about potential role alterations in CD39 (ENTPD1), ectonucleotidase responsible for conversion ATP ADP AMP, may play hypertension. In this study we identified decreased expression on endothelium patients with...