A5100398219- Spondyloarthritis Studies and Treatments
- Tryptophan and brain disorders
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- GaN-based semiconductor devices and materials
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Semiconductor materials and devices
- Circadian rhythm and melatonin
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Ion Channels and Receptors
- Connective tissue disorders research
- Business Process Modeling and Analysis
- Ga2O3 and related materials
- Treatment of Major Depression
- Psoriasis: Treatment and Pathogenesis
- Service-Oriented Architecture and Web Services
- Autoimmune and Inflammatory Disorders Research
- Pain Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Spinal Cord Injury Research
- Protein Degradation and Inhibitors
- Adipose Tissue and Metabolism
- Reconstructive Facial Surgery Techniques
Hanyang University
2016-2025
Anyang University
2014-2024
Chungnam National University
2023
Catholic University of Korea
2016
Seoul National University
2016
Kyung Hee University
2015
CHA Bundang Medical Center
2015
CHA University
2015
Significance The rapid antidepressant response is produced by ketamine administration. However, the molecular mechanisms underlying antidepressant-like action of remain incomplete. Here we show for first time to our knowledge that stimulates phosphorylation (Ser259/Ser498) and nuclear export histone deacetylase 5 (HDAC5). As a consequence, myocyte enhancer factor 2 (MEF2) transcriptional activity enhanced results in induction MEF2 target gene expression. We further down-regulates and, at...
To demonstrate the immune landscape of blood and synovial cells in setting ankylosing spondylitis (AS) through analysis both single-cell transcriptome surface protein expression, to unveil molecular characteristics pathogenic Th17 cells.This study included 40 individuals with active AS, 20 stable patients rheumatoid arthritis, healthy controls. Surface phenotype intracellular staining were assessed using flow cytometry after peripheral mononuclear fluid stimulated T cell receptor....
Stress causes changes in neurotransmission the brain, thereby influencing stress-induced behaviors. However, it is unclear how systems orchestrate stress responses at molecular and cellular levels. Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel involved mainly pain sensation, affects mood neuroplasticity where its role poorly understood. Here, we show that Trpv1-deficient (Trpv1−/−) mice are more resilient than control after chronic unpredictable stress. We...
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by ectopic bone formation. The anti-inflammatory function of dipeptidyl peptidase-4 (DPP4) inhibitor has been reported in metabolism, but its utility AS not previously investigated. We assessed DPP4 level serum, synovial fluid, and facet joint tissue patients. Additionally, we investigated the effect an experimental model using curdlan-injected SKG mice. Following curdlan injection, mice were orally administered...
Major depressive disorder (MDD) is a devastating disease that arises in background of environmental risk factors, such as chronic stress, produce reactive oxygen species (ROS) the brain. The stress-induced ROS production involves Ca2+ signals; however, mechanism poorly understood. Transient receptor potential melastatin type 2 (TRPM2) Ca2+-permeable cation channel highly expressed Here we show animal models unpredictable stress (CUS), deletion TRPM2 (Trpm2-/- ) produces antidepressant-like...
Functional consequences to which vertebrate GATA transcription factors contribute in the adult brain remain largely an open question. The present study examines how human GATA-1 and GATA-2 (hGATA-1 hGATA-2) are linked neuronal differentiation depressive behaviors rats. We investigated effects of adeno-associated viral expression hGATA-1 hGATA-2 (AAV-hGATA1 AAV-hGATA2) dentate gyrus (DG) dorsal hippocampus on dendrite branching spine number. also examined influence AAV-hGATA1 AAV-hGATA2...
Multipotent mesenchymal stem cells (MSCs) and MSC sheets have effective potentials of bone regeneration. Composite polymer/ceramic scaffolds such as poly‐ ε ‐caprolactone (PCL)/ β ‐tricalcium phosphate ( ‐TCP) are widely used to repair large defects. The present study investigated the in vitro osteogenic potential canine adipose‐derived MSCs (Ad‐MSCs) Ad‐MSC sheets. PCL/ ‐TCP seeded with Ad‐MSCs or wrapped (OCS) were also fabricated their was assessed following transplantation into...
Transient receptor potential vanilloid 1 (TRPV1) affects mood and neuroplasticity in the brain, where its role is poorly understood. In present study we investigated whether capsaicin (8-methyl-N-vanillyl-trans-6-nonenamide), an agonist of TRPV1, induced chromatin remodeling thereby altered gene expression related to synaptic plasticity. We found that treatment resulted upregulation histone deacetylase 2 (HDAC2) mouse hippocampus HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2...
Spondyloarthritis (SpA) usually manifests as arthritis of the axial and peripheral joints but can also result in extra-articular manifestations such inflammatory bowel disease. Proinflammatory cytokine interleukin-17 (IL-17) plays a crucial role pathogenesis SpA. Rebamipide inhibits signal transducer activator transcription 3 that controls IL-17 production Th17 cell differentiation. This study examined effect rebamipide on SpA development. SKG ZAP-70W163C mice were immunized with curdlan to...
Bone morphogenetic protein receptor type 2 (BMPR2) has been associated with radiographic changes in ankylosing spondylitis (AS), but further characterization of the cellular signaling pathway osteoprogenitor (OP) is not clearly understood. The aim this study was to investigate expression BMPR2 and bone (BMP2)-mediated responsibility AS.We collected 10 healthy control (HC) 14 AS-OPs derived from facet joints. Subsequently, we then conducted RNA sequencing two samples per group selected...
Enthesophyte formation plays a crucial role in the development of spinal ankylosis ankylosing spondylitis (AS). We aimed to investigate platelet-derived growth factor B (PDGFB) enthesophyte AS using vitro and vivo models determine association between PDGFB progression AS. Serum levels were measured patients healthy controls (HC). Human entheseal tissues attached facet joints or spinous processes harvested at time surgery investigated for bone-forming activity. The impact pharmacological...
Genetic screening is being widely applied to trace the origin of global developmental delay or intellectual disability. The 5q14.3 microdeletion has recently been uncovered as a clinical syndrome presenting with severe disability, limited walking ability, febrile convulsions, absence speech, and minor brain malformations. MEF2C was suggested gene mainly responsible for syndrome. We present case 6-year-old girl, who first patient in Korea de novo interstitial microdeletions involving 5q14.3,...
A number of business organizations are beginning to realize the importance process management. However, can often go way they were initially not designed for or a non-efficient performance model could be designed. To solve this problem, mining which used as basis re-engineering has been recognized an important concept. current research in domain only focused on extracting workflow-based from completed logs. Thus, there is limitation expressing various types processes, and moreover, discovery...