A5102809320- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Meta-analysis and systematic reviews
- Inflammatory Bowel Disease
- Anorectal Disease Treatments and Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Microscopic Colitis
Université Paris-Est Créteil
2024-2025
Summary Background Colorectal cancer (CRC) results from the accumulation of mutations and epigenetic changes in gut epithelial cells likely due to microbiota dysbiosis. However, limited research has been done explore link between host tumour dysbiosis disease outcome. Methods The mechanisms influencing outcomes 97 colorectal patients, including 13 with Lynch syndrome, 20 inflammatory bowel (IBD), 64 sporadic cases, were analyzed using a multiomics approach. These patients categorized into...
Purpose Through a pilot study, we performed whole gut metagenomic analysis in 17 Lynch syndrome (LS) families, including colorectal cancer (CRC) patients and their healthy first-degree relatives. In second asymptomatic LS cohort (n=150) undergoing colonoscopy-screening program, individuals with early precancerous lesions were compared to those normal colonoscopy. Since bacteria are organized into different networks within the microbiota, related network structures controls. Experimental...