A5029677928- Cholinesterase and Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- ECG Monitoring and Analysis
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Nicotinic Acetylcholine Receptors Study
- Computational Drug Discovery Methods
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Histone Deacetylase Inhibitors Research
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Non-Invasive Vital Sign Monitoring
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Blood Pressure and Hypertension Studies
- Genetics and Neurodevelopmental Disorders
- Heart Rate Variability and Autonomic Control
- Neurogenetic and Muscular Disorders Research
- Neuroscience and Neuropharmacology Research
- Health, Environment, Cognitive Aging
- Cardiovascular Disease and Adiposity
Aquinnah (United States)
2024
University of Pennsylvania
2015-2023
Hebrew University of Jerusalem
2005-2017
Institute of Life Sciences
2006
National Heart Lung and Blood Institute
1981-2003
National Institutes of Health
1981-2003
University of Connecticut
1993
University of Rochester Medical Center
1988
Washington Center
1969
United States Department of Veterans Affairs
1968
The Association for the Advancement of Medical Instrumentation develops voluntary standards medical devices so that manufacturers might provide information on their product and basic safety performance criteria should be considered in qualifying instrument clinical use. American national are generated through a consensus process by committees consisting experts research, development, design from user, industry, government communities. Draft made available public review may become after...
Immunoreactive parathyroid hormone was measured by radioimmunoassay in extracts of glands and tumors plasmas from patients with 1°, 2° or 3° hyperparathyroidism. On serial dilution most showed approximately parallel behavior 2 3 different antisera. However, plasma specimens referred to the same extract as standard frequently greater immunoreactivity antisera (272 273) than a third antiserum (C329). This anomaly more marked hyperparathyroidism secondary renal insufficiency 1° exhibited some...
Aging is the strongest risk factor for Alzheimer’s disease (AD), although underlying mechanisms remain unclear. The chromatin state, in particular through mark H4K16ac, has been implicated aging and thus may play a pivotal role age-associated neurodegeneration. Here we compare genome-wide enrichment of H4K16ac lateral temporal lobe AD individuals against both younger elderly cognitively normal controls. We found that while leads to enrichment, entails dramatic losses proximity genes linked...
Genetic studies link inherited errors in RNA metabolism to familial neurodegenerative disease. Here, we report such and the underlying mechanism sporadic Alzheimer's disease (AD). AD entorhinal cortices presented globally impaired exon exclusions selective loss of hnRNP A/B splicing factors. Supporting functional relevance, knockdown induced alternative impairments dendrite primary neurons, memory electrocorticographic mice. Transgenic mice with disease-associated mutations APP or Tau...
Alzheimer's disease (AD) involves loss of cholinergic neurons and Tau protein hyper-phosphorylation. Here, we report that overexpression an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in both these phenomena.In transfected primary brain cultures, induced cell death, morphological impairments caspase 3 activation. Rapid internalization fluorescently labeled fasciculin-2 to cells indicated membranal localization. In cultured lines, transfection...
Alzheimer's disease has long been known to involve cholinergic deficits, but the linkage between gene expression and amyloid pathology remained incompletely understood. One link involves synaptic acetylcholinesterase (AChE-S), shown accelerate fibrils formation. Here, we report that 'Readthrough' AChE-R splice variant, which differs from AChE-S in its 26 C-terminal residues, inversely exerts neuroprotective effects β (Aβ) induced toxicity. In vitro, highly purified dose-dependently...
Epilepsy is a common neurological disease, manifested in unprovoked recurrent seizures. Epileptogenesis may develop due to genetic or pharmacological origins following injury, but it remains unclear how the unaffected brain escapes this susceptibility Here, we report that dynamic changes forebrain microRNA (miR)-211 mouse shift threshold for spontaneous and pharmacologically induced seizures alongside cholinergic pathway genes, implicating miR avoidance of We identified miR-211 as putative...
TDP-43 is the major disease protein associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration ubiquitinated inclusions (FTLD-TDP). Here we identify transcriptional elongation factor Ell-a shared component of little complex (LEC) super (SEC)-as a strong modifier TDP-43-mediated neurodegeneration. Our data indicate select targets LEC SEC become upregulated in fly ALS/FTLD-TDP model. Among them, U12 snRNA stress-induced long non-coding RNA Hsrω, functionally...
The morphologic description and measurements of endarterectomy specimens are usually believed to be accurate used as the gold standard against which findings diagnostic procedures judged. Pathology data on 289 from five participating centers corresponding angiography B-mode ultrasonography provided a basis for scrutinizing validity using standard. Discrepancies greater than 1 mm between pathology minimum residual lumen occurred in 35% cases 64% cases. pathology- angiography-measured lesion...
Current mouse models of Alzheimer's disease show brain pathology that correlates to a degree with memory impairment, but underlying molecular mechanisms remained unknown. Here we report studies three lines transgenic mice: animals doubly express mutated human amyloid precursor protein (APPswe) and acetylcholinesterase (hAChE); for only the APPswe or hAChE. Among these genotypes, variations were observed in expression mRNA presenilin-1, which was highest singly hAChE mice, stress-inducible...
The proposed recommendations for continuous electrocardiographic monitoring systems represent goals future development. Description of a technique in the report does not constitute an endorsement its clinical use. Lead ECG must adequately sense cardiac electrical field and leads should be standardized. Future monitors capable simultaneously displaying analyzing multiple leads. Recommendations electrode placement position patient are made. Important parameters each category standards...
RNA-binding proteins (RBPs) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the underlying disease mechanisms remain unclear. In an unbiased screen in Drosophila for RBPs that genetically interact TDP-43, we found downregulation of mRNA export factor Ref1 (fly orthologue to human ALYREF) mitigated TDP-43 induced toxicity. Further, depletion also reduced toxicity caused by expression C9orf72 GGGGCC repeat expansion. knockdown lowered levels these...
<i>Background:</i> In Alzheimer’s disease (AD), cholinergic neurons are particularly vulnerable for as yet unclear reasons. Here, we report that modified composition, localization and properties of alternative splice variants encoding the acetylcholine-hydrolyzing enzyme acetylcholinesterase (AChE) may be variably involved in progression or systemic efforts to attenuate its progression. <i>Objective:</i> The purpose this study was explore implications AD cellular...