A5033363992- Animal Genetics and Reproduction
- Genetic and phenotypic traits in livestock
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic Mapping and Diversity in Plants and Animals
- Sexual Differentiation and Disorders
- Chromosomal and Genetic Variations
- Regulation of Appetite and Obesity
- Meat and Animal Product Quality
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Adipose Tissue and Metabolism
- Animal Nutrition and Physiology
- Urological Disorders and Treatments
- Biochemical Analysis and Sensing Techniques
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- melanin and skin pigmentation
- Congenital heart defects research
- Peroxisome Proliferator-Activated Receptors
- Genomic variations and chromosomal abnormalities
- Genetic diversity and population structure
- Genetic factors in colorectal cancer
- Testicular diseases and treatments
University of Life Sciences in Poznań
2016-2025
Institute of Plant Genetics, Polish Academy of Sciences
1983-2024
University of Life Sciences in Lublin
2010-2018
University of Cincinnati Medical Center
2017
Swedish University of Agricultural Sciences
1989-2008
Akademia Wychowania Fizycznego im. Eugeniusza Piaseckiego w Poznaniu
2008
Instytut Środowiska Rolniczego i Leśnego Polskiej Akademii Nauk
1992-2007
University of Agriculture in Krakow
1991-2007
University of Guelph
2004
École Polytechnique Fédérale de Lausanne
1983-1998
Abstract Xenotransplantation from pigs could alleviate the shortage of human tissues and organs for transplantation. Means have been identified to overcome hyperacute rejection acute vascular mechanisms mounted by recipient. The challenge is combine multiple genetic modifications enable normal animal breeding meet demand transplants. We used two methods colocate xenoprotective transgenes at one locus, sequential targeted transgene placement - ‘gene stacking’ cointegration engineered large...
Congenital malformations resulting in late abortions and stillbirths affect the economic wellbeing of producers welfare cattle breeding programs. An extremely high incidence "half-sized" calves normal karyotype uninflated lungs was diagnosed progeny Finnish Ayrshire (Bos taurus) bull - YN51. No other visible anatomical abnormalities were apparent stillborn calves. We herein describe positional identification a 110 kb microdeletion maternally imprinted PEG3 domain that results loss paternal...
Studies in cultured cells have demonstrated the existence of higher-order epigenetic mechanisms, determining relationship between expression gene and its position within cell nucleus. It is unknown, whether such mechanisms operate postmitotic, highly differentiated types, as neurons vivo. Accordingly, we examined intranuclear positions Bdnf Trkb genes, encoding major neurotrophin receptor respectively, change a result neuronal activity, what functional consequences movements may have. In rat...
Cryptorchidism is the most common form of disorder sex development in male dogs, but its hereditary predisposition poorly elucidated. The gonadal transcriptome nine unilaterally cryptorchid dogs and seven control was analyzed using RNA-seq. Comparison between scrotal inguinal gonads unilateral revealed 8,028 differentially expressed genes (DEGs) (3,377 up-regulated 4,651 down-regulated). A similar number DEGs (7,619) found by comparing undescended testicles with descended dogs. methylation...
Hypospadias is rarely reported in dogs. In this study we pre-sent 2 novel cases of disorder sexual development and, addition, a case hereditary sex reversal female with an enlarged clitoris. The first was male Moscow watchdog normal karyotype (78,XY) and the presence <i>SRY</i> gene. dog, perineal hypospadias, bilateral inguinal cryptorchidism testes were observed. second case, representing Cocker spaniel breed, had small penis hypospadic orifice urethra, cryptorchidism, testis...
Summary A missense G–A SNP in the porcine melanocortin‐4 receptor (MC4R) gene that causes an Asp–Asn substitution at position 298 of corresponding MC4R protein is considered to be economically important, although published results on its effect are inconsistent. We analysed association this polymorphism with production traits 679 gilts from two breeds, Polish Large White (PLW) and Landrace (PL), as well one synthetic line 990. The frequency allele differed significantly among breeds...
Synaptonemal complex analyses were carried out by electron microscopy on surface-spread spermatocytes of one normal bull and two bulls that heterozygous for the so-called 1;29 translocation. The autosomal bivalents karyotype, which could be arranged size in a series, demonstrated kinetochores at terminally located attachment plaques. One bivalent was clearly larger than rest apparently consisted long arm translocation longest autosome set had kinetochore subtelocentric position. Some pairs...
Summary Three non‐synonymous single nucleotide polymorphisms (T221C, T232A and C233T) were detected in exon 4 of the porcine leptin receptor ( LEPR ) gene. The substitution could be identified as a Tsp 509I) restriction fragment length polymorphism. frequency genotype TT varied six genetic groups from 0.62 (Duroc) to 0.99 (Polish Large White). Sequencing 4, performed for 30 animals, revealed that only two intragenic haplotypes (TC AT at position 232–233) present. phenotypic effect 509I...
The mitotic and meiotic chromosomes of four male silver foxes (<i>Vulpes fulvus </i>Desm.) having, due to inter- intraindividual variation, 1–4 B-chromosomes in addition the standard karyotype, were investigated with special attention given pachytene chromosome behaviour as revealed by electron light microscopy. When occurring univalents demonstrated a progressively folding back behavior ending intrachromosomal pairing. two occurred same cell they paired normally bivalent one...
Impaired migration of primordial germ cells during embryonic development causes hereditary gonadal hypoplasia in both sexes Northern Finncattle and Swedish Mountain cattle. The affected gonads exhibit a lack or, rare cases, reduced number cells. Most animals present left-sided hypoplasia. However, right-sided bilateral cases are also found. This type prevails with white coat colour. Previous studies indicated that is inherited an autosomal recessive fashion incomplete penetrance. In order to...
Fat content and fatty acid (FA) profile influence meat quality in pigs. These parameters are important for consumers due to their preferences healthy, high meat. The aim of this study was searching polymorphisms transcript levels two positional functional candidate genes, FASN INSIG2, encoding proteins which take part lipid metabolism. molecular findings were analyzed relation fatness traits. Pigs four commercial breeds included: Polish Landrace (PL), Large White (PLW), Duroc Pietrain. DNA...