A5040080908- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- FOXO transcription factor regulation
- Hormonal Regulation and Hypertension
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- interferon and immune responses
Gynecologic Oncology Group
2024-2025
Target (United States)
2024-2025
Third Affiliated Hospital of Guangzhou Medical University
2020-2025
Guangzhou Medical University
2020-2025
Key Laboratory of Guangdong Province
2024-2025
Liaoning Cancer Hospital & Institute
2023
Dalian University of Technology
2023
Abstract Circular RNAs (circRNAs) play important roles in cancer tumorigenesis and progression, representing prognostic biomarkers therapeutic targets. In this case, we demonstrated the role of circ-NOLC1 epithelial ovarian (EOC). Our results have shown that Circ-NOLC1 expression was higher EOC tissues than normal tissues, positively associated with FIGO stage, differentiation. Among cell lines, highest A2780, lowest CAOV3. Overexpression CAOV3 cells increased proliferation, migration,...
Abstract Background Most of the endometrial cancer (EC) patients are diagnosis in early stage with a good prognosis while locally advanced recurrent or metastatic result poor prognosis. Adjuvant therapy could benefit high-risk factors. Unfortunately, molecular classification great prognostic value has not yet reached an agreement and need to be further refined. The present study aims identify new targets that have EC based on method patient-derived organ-like organs (PDOs), investigate their...
Abstract Ovarian cancer (OC) is a heterogeneous cancer. In contrast to other tumor cells, which rely primarily on aerobic glycolysis (Warburg effect) as their energy source, oxidative phosphorylation (OXPHOS) also one of its major metabolic modes. Piwi-interacting RNAs (piRNAs) play regulatory function in various biological processes cells. However, the role and mechanisms piRNAs OC mitochondrial OXPHOS remain be elucidated. Here, we found that piR-26441 was aberrantly downregulated OC,...
Small nucleolar RNAs (snoRNAs) are a class of non-coding widely distributed in eukaryotic nucleoli. In recent years, studies have revealed that snoRNAs can also participate the occurrence and development malignant tumors through different pathways. Cervical cancer is one most common female reproductive system, high-risk HPV virus infection its main pathogenic mechanism. However, outcomes patients with vary, indicating other factors might affect process cervical cancer. this study, we...
Endometrial cancer (EC) is a common gynaecological malignant tumour with unclear pathogenesis. Small nucleolar RNA (snoRNA) involved in many biological processes, including those of cancers. Using the Cancer Genome Atlas (TCGA) database, expression pattern snoRNA, SNORA73B, was analysed. The functions SNORA73B were assessed by vitro proliferation, apoptosis, migration, and invasion assays vivo xenograft model. sequencing (RNA-seq) immunoprecipitation performed to determine relationship...
Endometrial carcinoma (EC) is one of the most common gynecological malignant tumors. Our study showed that long non-coding RNA (lncRNA) linc01194 plays an important role in EC. We explored mechanism lncRNA
Breast cancer (BC) is the most common in women and second leading cause of cancer-related death worldwide after lung cancer.1 At molecular level, it divided into subtypes based on binding (presence or absence) estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2). The prognosis treatment strategy BC are determined by expression these receptors. Despite advances early diagnosis effectiveness, this study aims to discover tumor markers new therapeutic strategies....
Endometrial cancer is associated with a high mortality rate, which warrants the identification of novel diagnostic markers and therapeutic targets. The aim this study to evaluate role SNORD15B in development endometrial explore potential underlying mechanisms. Bioinformatics was used analyze expression level prognostic relevance cancer. Ishikawa HEC-1B cells were respectively transfected plasmid an antisense oligonucleotide, or corresponding empty vector nonspecific sequence. malignant...
Abstract Background: Circular RNAs (circRNAs) play important roles in cancer tumorigenesis and progression, could represent prognostic biomarkers therapeutic targets. Herein, we demonstrated the role of circNOLC1 epithelial ovarian (EOC). Methods: CircNOLC1 expression was quantified tissues normal using quantitative real-time reverse transcriptase. After overexpression or downregulation a plasmid short hairpin RNA (shRNA) transfection, respectively, cell phenotypes molecular mechanisms were...