A5037595735- Parkinson's Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Alzheimer's disease research and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Endoplasmic Reticulum Stress and Disease
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Phytoestrogen effects and research
- Ginkgo biloba and Cashew Applications
- Sulfur Compounds in Biology
- Biochemical effects in animals
- Heat shock proteins research
- Retinoids in leukemia and cellular processes
- Prion Diseases and Protein Misfolding
- Neurological disorders and treatments
- Obsessive-Compulsive Spectrum Disorders
- Neurological Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- DNA Repair Mechanisms
- Cancer-related cognitive impairment studies
- Aluminum toxicity and tolerance in plants and animals
- Neuroscience and Neuropharmacology Research
Duquesne University
2015-2022
Midwestern University
2019-2022
α-synucleinopathy emerges quite early in olfactory structures such as the bulb and anterior nucleus (OB/AON) Parkinson's disease. This may contribute to smell impairments years before commencement of motor symptoms. We tested whether can spread from OB/AON regions limbic telencephalon that harbor connections with structures. α-synuclein fibrils were infused into OB/AON. Inclusions containing pathologically phosphorylated (pSer129) observed three months later piriform entorhinal cortices,...
Diabetic obesity in the leptin-deficient ob/ob mouse is associated with weight gain, and hyperglycemia, along hyperinsulinemia. We have previously examined effects of genistein (a naturally occurring isoflavone found soy) on metabolic disturbances demonstrated beneficial (600 mg genistein/kg diet, for 4-weeks) T3 production corticosterone status. The goal this study was to examine whether dietary could prevent, or at least lessen, typical phenotype murine model diabetic-obesity, assess...
The dual-hit hypothesis of neurodegeneration states that severe stress sensitizes vulnerable cells to subsequent challenges so the two hits are synergistic in their toxic effects. Although hippocampus is a number neurodegenerative disorders, there no models cell death hippocampal neurons response combined proteotoxic and oxidative stressors, major characteristics these diseases. Therefore, relatively high-throughput model synergy was developed primary neurons. In order increase rigor study...
Abstract At early disease stages, Lewy body disorders are characterized by limbic vs. brainstem α‐synucleinopathy, but most preclinical studies have focused solely on the nigrostriatal pathway. Furthermore, male gender and advanced age two major risk factors for this family of conditions, their influence topographical extents α‐synucleinopathy degree cell loss uncertain. To fill these gaps, we infused α‐synuclein fibrils in olfactory bulb/anterior nucleus complex—one earliest frequently...
Abstract The olfactory bulb is one of the most vulnerable brain regions in age‐related proteinopathies. Proteinopathic stress mitigated by heat shock protein (Hsp) family chaperones. Here, we describe decreases Hsc70 female rat and higher levels Hsp70 Hsp25 middle old age than at 2–4 months. To model proteotoxic oxidative , primary cultures were treated with proteasome inhibitors lactacystin MG 132 or pro‐oxidant paraquat. Toxin‐induced increases observed Hsp70, Hsp25, Hsp32. determine...
Growing evidence has demonstrated the benefits of regular exercise on cardiovascular, neural, and cognitive function in humans with Alzheimer’s disease (AD). However, consequences AD gastrointestinal morphology effects exercise, which plays an important role against development certain gastrointestinal-related diseases, are still poorly understood. Therefore, to assess changes intestinal structure a mouse model impact 2-month-old 3xTg-AD male mice were subjected treadmill running 5 days per...